Ranked list of P. falciparum targets for PLOS-NTD

Posted by Dany Shanmugam on 2009-09-05 11:30:53

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page. You can also access the previous version of the database at v3.tdrtargets.org

Genomic scale ranking of P. falciparum genes using the same set of queries that were used for the L. major list. This demonstrates that the same set of queries may be used to rank targets in various pathogens.

Score for genes in query #78 (Pfa enz (EC + func. Categ.)): 100
Score for genes in query #79 (Pfa Pubmed): 35
Score for genes in query #80 (Pfa mwt <100kDa): 20
Score for genes in query #81 (Pfa no TM domain): 20
Score for genes in query #82 (Pfa PDB): 50
Score for genes in query #83 (Pfa modbase): 30
Score for genes in query #84 (Pfa not in humans): 25
Score for genes in query #85 (Pfa any genetic validation): 50
Score for genes in query #86 (Pfa any essentiality evidence): 50
Score for genes in query #87 (Pfa dindex >=0.6): 35
Score for genes in query #88 (Pfa Compd desirability >0.3): 35
Score for genes in query #89 (Pfa assayable): 35
Score for genes in query #90 (Pfa all proteins): 1
Score for genes in query #93 (Pfa in Pvi): 25

Queries in this set

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy

Select: All, None.

  Pfa enzyme (EC + functional category) (1228 records). Show parameters.

  Pfa in Pubmed (695 records). Show parameters.

  Pfa molecular weight <100kDa (3942 records). Show parameters.

  Pfa no TM domain (3197 records). Show parameters.

  Pfa PDB structure (253 records). Show parameters.

  Pfa Modbase structure model (2756 records). Show parameters.

  Mtb not in humans (now searched on pfa) (3310 records). Show parameters.

  Pfa any genetic validation (28 records). Show parameters.

  Pfa any essentiality (1054 records). Show parameters.

  Pfa Dindex >=0.6 (16 records). Show parameters.

  Pfa Compound desirability >0.3 (103 records). Show parameters.

  Pfa assayable (254 records). Show parameters.

  Pfa all proteins (3999 records). Show parameters.

  Pfa ortholog in taxon (Pvi) (4540 records). Show parameters.

  Weighted ranking of Pfa targets for PLOS-NTD (5590 records). Show parameters.