Ranked list of S.mansoni targets for PLOS-NTD

Posted by Dany Shanmugam on 2009-10-10 12:39:56

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page. You can also access the previous version of the database at v3.tdrtargets.org

Genomic scale ranking of S. mansoni genes emphasizing phenotype, expression, curation and druggable data.

Score for genes in query #208 (Sma EC numbers - uploaded list): 10
Score for genes in query #209 (Orthologs of D. melanogaster genes with mutant phenotype lethal): 10
Score for genes in query #210 (Orthologs of D. melanogaster genes with mutant phenotype neurophysiological defect): 10
Score for genes in query #211 (Embryonic Lethal/Arrest in C. elegans): 10
Score for genes in query #212 (Growth Defect in C. elegans): 3
Score for genes in query #213 (Larval/Adult Lethal/Arrest in C. elegans): 10
Score for genes in query #214 (Morphology Defect in C. elegans): 3
Score for genes in query #215 (Sterility in C. elegans): 3
Score for genes in query #216 (any essentiality evidence): 3
Score for genes in query #217 (structural model available): 10
Score for genes in query #218 (druggable genes inferred by sequence simiarity): 10
Score for genes in query #219 (expressed in adult worm (ESTs)): 3
Score for genes in query #220 ( expressed in egg stage (ESTs)): 3
Score for genes in query #221 ( expressed in schistosomula stage (ESTs)): 3
Score for genes in query #222 (expressed in any relevant stage (ESTs)): 10
Score for genes in query #223 (Sma all proteins): 1
Score for genes in query #225 (Sma in Cel): 10
Score for genes in query #226 (Sma uploaded list of metabolic chokepoint enzymes (Berriman et al, 2009)): 10
Score for genes in query #227 (Sma uploaded list of targets identified by STARlite search (Berriman et al, 2009)): 10
Score for genes in query #228 (Sma uploaded list of targets similar to known human targets (Berriman et al, 2009)): 10

Queries in this set

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy

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  Sma EC numbers - uploaded list (693 records). Show parameters.

  Orthologs of D. melanogaster genes with mutant phenotype lethal (2207 records). Show parameters.

  Orthologs of D. melanogaster genes with mutant phenotype neurophysiological defect (382 records). Show parameters.

  Embryonic Lethal/Arrest in C. elegans (2269 records). Show parameters.

  Growth Defect in C. elegans (1195 records). Show parameters.

  Larval/Adult Lethal/Arrest in C. elegans (1476 records). Show parameters.

  Morphology Defect in C. elegans (787 records). Show parameters.

  Sterility in C. elegans (1550 records). Show parameters.

  any essentiality evidence (3209 records). Show parameters.

  structural model available (8831 records). Show parameters.

  druggable genes inferred by sequence simiarity (846 records). Show parameters.

  expressed in adult worm (ESTs) (6961 records). Show parameters.

  expressed in egg stage (ESTs) (4955 records). Show parameters.

  expressed in schistosomula stage (ESTs) (5249 records). Show parameters.

  expressed in any relevant stage (ESTs) (8618 records). Show parameters.

  Sma all proteins (13167 records). Show parameters.

  Sma in Cel (5951 records). Show parameters.

  Sma uploaded list of metabolic chokepoint enzymes (Berriman et al, 2009) (151 records). Show parameters.

  Sma uploaded list of targets identified by STARlite search (Berriman et al, 2009) (90 records). Show parameters.

  Sma uploaded list of targets similar to known human targets (Berriman et al, 2009) (28 records). Show parameters.

  Weighted ranking of Sma targets for PLOS-NTD (13167 records). Show parameters.