tcruzi targets shared with leishmania, absent in tbrucei

Posted by Fernan Aguero on 2010-04-13 13:21:09

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page. You can also access the previous version of the database at v3.tdrtargets.org

T. cruzi targets that are also present in Leishmania, but that are absent in T. brucei.

The prioritization strategy includes some other general (basic) attributes, apart from the phylogenetic ones, as described below:

Query #1 (amastigote expression >= 2 spectra / 2 peptides): 20
Query #10 (tcruzi all genes): 1
Query #11 (tcruzi not in humans): 80
Query #12 (tcruzi in leish): 90
Query #13 (tcruzi not in tbrucei): 150
Query #14 (tcruzi reagent availability): 30
Query #15 (tcruzi assay available): 30
Query #2 (is enzyme): 20
Query #3 (3D structure): 10
Query #4 (3D model): 10
Query #5 (any evidence of essentiality): 50
Query #6 (> 3 paralogs): -30
Query #7 (druggability > .5): 60
Query #8 (bibrefs): 25
Query #9 (low molecular weight (< 100 kDa)): 25

Queries in this set

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  amastigote expression >= 2 spectra / 2 peptides (589 records). Show parameters.

  is enzyme (5474 records). Show parameters.

  3D structure (74 records). Show parameters.

  3D model (7103 records). Show parameters.

  any evidence of essentiality (2313 records). Show parameters.

  > 3 paralogs (5442 records). Show parameters.

  druggability > .5 (325 records). Show parameters.

  bibrefs (461 records). Show parameters.

  low molecular weight (< 100 kDa) (22872 records). Show parameters.

  tcruzi all genes (25013 records). Show parameters.

  tcruzi not in humans (20831 records). Show parameters.

  tcruzi in leish (11567 records). Show parameters.

  tcruzi not in tbrucei (12620 records). Show parameters.

  tcruzi reagent availability (205 records). Show parameters.

  tcruzi assay available (334 records). Show parameters.

  Union of (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15) (25013 records). Show parameters.