Brugia malayi genome prioritization including C. elegans tissue-specific gene expression data

Posted by Santiago Carmona on 2011-06-16 17:05:34

This ranked list of B. malayi targets was constructed from the published list 361 (for PLOS-NTD paper, http://tdrtargets.org/published/browse/361 ) by including additional criteria based on C. elegans tissue specific gene expression data.
C. elegans Neuron and Muscle specifically expressed genes (predicted) data was taken from "Global Prediction of Tissue-Specific Gene Expression and Context-Dependent Gene Networks in Caenorhabditis elegans", Chikina et. al.
Both gene sets were mapped to B. malayi genome. More information available in http://tdrtargets.org/published/browse/392
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Queries in this set

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  B. malayi orthologs of C. elegans genes differentially expressed in muscle (519 records). Show parameters.

  B. malayi orthologs of C. elegans genes differentially expressed in neurons (430 records). Show parameters.

  Bma druggable precedence by similarity to starlite targets (806 records). Show parameters.

  Bma - sterile in Cel (1461 records). Show parameters.

  Bma modbase (7870 records). Show parameters.

  Bma pubmed (212 records). Show parameters.

  Bma in Cel (7260 records). Show parameters.

  Bma - embryonic lethal/arrest in Cel (2284 records). Show parameters.

  Bma - growth defect in Cel (1104 records). Show parameters.

  Bma - larval/adult lethal/arrest in Cel (1421 records). Show parameters.

  Bma - morphology defect in Cel (714 records). Show parameters.

  Bma any essentiality (3227 records). Show parameters.

  Bma any EC (637 records). Show parameters.

  Bma in PDB (1 record). Show parameters.

  Bma assayable (29 records). Show parameters.

  Bma all proteins (11508 records). Show parameters.

  Union of (23, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41) (11508 records). Show parameters.

  top-25 of ranked list for PLOS-NTD; Posted List 361, No tissue-differential gene expression data (25 records). Show parameters.

  top-100 of ranked list for PLOS-NTD; Posted List 361, No tissue-differential gene expression data (100 records). Show parameters.

  Weighted list for comparison of PLOS-NTD's vs. this B. malayi targets prioritization (11508 records). Show parameters.