T. brucei query set (DSR VI/11/07)

Posted by David Roos on 2007-06-11 09:40:48

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page. You can also access the previous version of the database at v3.tdrtargets.org

A set of attributes potentially relevant to T. brucei drug target design, including:
- enzymes [100]
- MW <100 kDa [20]
- no TM domains [20]
- structure available in PDB [50]
- model available in ModBase [30]
- present in all TriTryps [25]
- NOT in human [25]
- essentiality evidence in some (other) organism(s) [40]
- essential in T. brucei (lethal RNAi or KO phenotype) [50]
- druggability evidence inferred from orthology (>0.6) [35]
- compound desirability inferred from orthology (>0.3) [35]
- publications in PubMed [35]

Queries in this set

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
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  T. brucei targets - composite weighted query (DSR) (10965 records). Show parameters.

  T. brucei enzymes (776 records). Show parameters.

  T. brucei models (7119 records). Show parameters.

  Present in all TriTryps (7332 records). Show parameters.

  T. brucei, NOT human (5735 records). Show parameters.

  Essential (in any organism) (1375 records). Show parameters.

  T. brucei <100kDa (9913 records). Show parameters.

  Druggability precedent (>0.6) (234 records). Show parameters.

  Compound desirability (>0.3) (399 records). Show parameters.

  T. brucei no TM domains (9313 records). Show parameters.

  T. brucei published (549 records). Show parameters.

  T. brucei lethal (KO or KD) (59 records). Show parameters.

  T. brucei 3D structures (80 records). Show parameters.