Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.
460 records found | Showing page 1 of 19 (records 1-25) | Number of records to display | Find orthologs in
| Organism | Name | Ortholog group | Product |
|---|---|---|---|
| M. tuberculosis | Rv0005 | OG5_128755 | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisome ... |
| M. tuberculosis | Rv0014c | OG5_146588 | Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) |
| M. tuberculosis | Rv0015c | OG5_155711 | Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A) |
| M. tuberculosis | Rv0058 | OG5_131890 | Probable replicative DNA helicase DnaB |
| M. tuberculosis | Rv0060 | OG5_133608 | Conserved hypothetical protein |
| M. tuberculosis | Rv0085 | OG5_147565 | Possible hydrogenase HycP |
| M. tuberculosis | Rv0086 | OG5_134238 | Possible hydrogenase HycQ |
| M. tuberculosis | Rv0102 | OG5_156768 | Probable conserved integral membrane protein |
| M. tuberculosis | Rv0107c | OG5_215400 | Probable cation-transporter ATPase I CtpI |
| M. tuberculosis | Rv0112 | OG5_149659 | Possible GDP-mannose 4,6-dehydratase Gca (GDP-D-mannose dehydratase) |
| M. tuberculosis | Rv0118c | OG5_126899 | Probable oxalyl-CoA decarboxylase OxcA |
| M. tuberculosis | Rv0119 | OG5_126609 | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA ... |
| M. tuberculosis | Rv0127 | OG5_239105 | Maltokinase Mak |
| M. tuberculosis | Rv0148 | OG5_129142 | Probable short-chain type dehydrogenase/reductase |
| M. tuberculosis | Rv0166 | OG5_126609 | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA ... |
| M. tuberculosis | Rv0167 | OG5_130961 | Conserved integral membrane protein YrbE1A |
| M. tuberculosis | Rv0189c | OG5_128618 | Probable dihydroxy-acid dehydratase IlvD (dad) |
| M. tuberculosis | Rv0205 | OG5_131504 | Probable conserved transmembrane protein |
| M. tuberculosis | Rv0208c | OG5_127179 | Hypothetical methlytransferase (methylase) |
| M. tuberculosis | Rv0227c | OG5_237823 | Probable conserved membrane protein |
| M. tuberculosis | Rv0228 | OG5_176236 | Probable integral membrane acyltransferase |
| M. tuberculosis | Rv0270 | OG5_126609 | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA ... |
| M. tuberculosis | Rv0282 | OG5_132590 | ESX conserved component EccA3. ESX-3 type VII secretion system protein. |
| M. tuberculosis | Rv0283 | OG5_237818 | ESX conserved component EccB3. ESX-3 type VII secretion system protein. Possible ... |
| M. tuberculosis | Rv0285 | OG5_204583 | PE family protein PE5 |