Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.
213 records found | Showing page 1 of 9 (records 1-25) | Number of records to display | Find orthologs in
| Organism | Name | Ortholog group | Product |
|---|---|---|---|
| M. tuberculosis | Rv0006 | OG5_129568 | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisome ... |
| M. tuberculosis | Rv0009 | OG5_128211 | Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (r ... |
| M. tuberculosis | Rv0014c | OG5_146588 | Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) |
| M. tuberculosis | Rv0058 | OG5_131890 | Probable replicative DNA helicase DnaB |
| M. tuberculosis | Rv0062 | OG5_137267 | Possible cellulase CelA1 (endoglucanase) (endo-1,4-beta-glucanase) (FI-cmcase) ( ... |
| M. tuberculosis | Rv0066c | OG5_126691 | Probable isocitrate dehydrogenase [NADP] Icd2 (oxalosuccinate decarboxylase) (ID ... |
| M. tuberculosis | Rv0129c | OG5_237839 | Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transfe ... |
| M. tuberculosis | Rv0153c | OG5_132308 | Phosphotyrosine protein phosphatase PTPB (protein-tyrosine-phosphatase) (PTPase) |
| M. tuberculosis | Rv0183 | OG5_127037 | Possible lysophospholipase |
| M. tuberculosis | Rv0194 | OG5_126596 | Probable transmembrane multidrug efflux pump |
| M. tuberculosis | Rv0211 | OG5_129007 | Probable iron-regulated phosphoenolpyruvate carboxykinase [GTP] PckA (phosphoeno ... |
| M. tuberculosis | Rv0222 | OG5_169926 | Probable enoyl-CoA hydratase EchA1 (enoyl hydrase) (unsaturated acyl-CoA hydrata ... |
| M. tuberculosis | Rv0234c | OG5_127004 | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 |
| M. tuberculosis | Rv0247c | No group | Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) |
| M. tuberculosis | Rv0248c | OG5_126927 | Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) |
| M. tuberculosis | Rv0262c | OG5_237819 | Aminoglycoside 2'-N-acetyltransferase Aac (Aac(2')-IC) |
| M. tuberculosis | Rv0319 | OG5_128512 | Probable pyrrolidone-carboxylate peptidase Pcp (5-oxoprolyl-peptidase) (pyroglut ... |
| M. tuberculosis | Rv0334 | OG5_131815 | Alpha-D-glucose-1-phosphate thymidylyltransferase RmlA (dTDP-glucose synthase) ( ... |
| M. tuberculosis | Rv0363c | OG5_131639 | Probable fructose-bisphosphate aldolase Fba |
| M. tuberculosis | Rv0392c | OG5_126960 | Probable membrane NADH dehydrogenase NdhA |
| M. tuberculosis | Rv0409 | OG5_130287 | Probable acetate kinase AckA (acetokinase) |
| M. tuberculosis | Rv0410c | OG5_210922 | Serine/threonine-protein kinase PknG (protein kinase G) (STPK G) |
| M. tuberculosis | Rv0429c | OG5_128237 | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) |
| M. tuberculosis | Rv0432 | OG5_127584 | Periplasmic superoxide dismutase [Cu-Zn] SodC |
| M. tuberculosis | Rv0456c | No group | enoyl-CoA hydratase EchA2 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crot ... |