Target list

Search results for query: Union of (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)

You can Modify weights (moves query to your history allowing re-weight functionality) to match your needs

  • Score for genes in query #5 (any evidence of essentiality): 50
  • Score for genes in query #14 (tcruzi reagent availability): 30
  • Score for genes in query #1 (amastigote expression >= 2 spectra / 2 peptides): 20
  • Score for genes in query #8 (bibrefs): 25
  • Score for genes in query #10 (tcruzi all genes): 1
  • Score for genes in query #6 (> 3 paralogs): -30
  • Score for genes in query #12 (tcruzi in leish): 90
  • Score for genes in query #11 (tcruzi not in humans): 80
  • Score for genes in query #4 (3D model): 10
  • Score for genes in query #2 (is enzyme): 20
  • Score for genes in query #3 (3D structure): 10
  • Score for genes in query #7 (druggability > .5): 60
  • Score for genes in query #13 (tcruzi not in tbrucei): 150
  • Score for genes in query #15 (tcruzi assay available): 30
  • Score for genes in query #9 (low molecular weight (< 100 kDa)): 25

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

18628 records found | Showing page 2 of 746 (records 26-50) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
T. cruzi   TcCLB.507617.9   OG5_126789   prostaglandin F2alpha synthase 376
T. cruzi   TcCLB.506577.120   OG5_132400   sterol C-24 reductase, putative 376
T. cruzi   TcCLB.507089.170   OG5_183999   hypothetical protein, conserved 376
T. cruzi   TcCLB.508955.20   OG5_166721   hypothetical protein, conserved 376
T. cruzi   TcCLB.507709.60   OG5_155636   hypothetical protein, conserved 376
T. cruzi   TcCLB.506679.130   OG5_173533   hypothetical protein, conserved 376
T. cruzi   TcCLB.506725.20   OG5_183999   hypothetical protein, conserved 376
T. cruzi   TcCLB.511761.60   OG5_130623   hypothetical protein, conserved 376
T. cruzi   TcCLB.508461.80   OG5_126789   prostaglandin F2alpha synthase 376
T. cruzi   TcCLB.511911.130   OG5_127226   phosphoglucomutase 371
T. cruzi   TcCLB.510773.20   OG5_128905   Vacuolar proton pyrophosphatase 1, putative 371
T. cruzi   TcCLB.511855.70   OG5_166691   CMGC/MAPK protein kinase, putative 371
T. cruzi   TcCLB.508535.50   OG5_176689   tyrosine aminotransferase 371
T. cruzi   TcCLB.510743.70   OG5_127627   lactoylglutathione lyase-like protein, putative 366
T. cruzi   TcCLB.511385.30   OG5_128905   vacuolar-type proton translocating pyrophosphatase 1 361
T. cruzi   TcCLB.484299.10     No group trypanothione reductase, putative 361
T. cruzi   TcCLB.511543.20   OG5_131881   As/Sb Reductase, putative 356
T. cruzi   TcCLB.509471.10   OG5_164195   hypothetical protein, conserved 356
T. cruzi   TcCLB.507949.40   OG5_154944   hypothetical protein, conserved 356
T. cruzi   TcCLB.507711.190   OG5_162858   hypothetical protein, conserved 356
T. cruzi   TcCLB.511459.50   OG5_166770   hypothetical protein, conserved 356
T. cruzi   TcCLB.509669.160   OG5_136124   hypothetical protein, conserved 356
T. cruzi   TcCLB.506181.104   OG5_131389   actyltransferase-like protein 356
T. cruzi   TcCLB.510329.150   OG5_155684   hypothetical protein, conserved 356
T. cruzi   TcCLB.505171.70   OG5_142740   ATP-dependent DEAD/H RNA helicase, putative 356

Showing page 2 (records 26-50) of 746