Target list

Search results for query: PLoS NTD Query 5 (M. tuberculosis)

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  • Score for genes in query #72 (Mtb assayable): 35
  • Score for genes in query #74 (Mtb all proteins): 1
  • Score for genes in query #62 (Mtb mwt <100kDa): 20
  • Score for genes in query #68 (Mtb any genetic validation): 50
  • Score for genes in query #70 (Mtb dindex >=0.6): 35
  • Score for genes in query #64 (Mtb PDB): 50
  • Score for genes in query #65 (Mtb modbase): 30
  • Score for genes in query #60 (Mtb enz (EC + func. Categ.)): 100
  • Score for genes in query #71 (Mtb Compd desirability >0.3): 35
  • Score for genes in query #69 (Mtb any essentiality evidence): 50
  • Score for genes in query #63 (Mtb no TM domain): 20
  • Score for genes in query #66 (Mtb not in humans): 25
  • Score for genes in query #61 (Mtb Pubmed): 35
  • Score for genes in query #67 (Mtb in Mle): 25

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

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2253 records found | Showing page 1 of 91 (records 1-25) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
M. tuberculosis   Rv1484   OG5_130466   NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl ... 511
M. tuberculosis   Rv2537c   OG5_132746   3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) 406
M. tuberculosis   Rv2763c   OG5_128410   Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 406
M. tuberculosis   Rv3602c   OG5_129569   Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activatin ... 406
M. tuberculosis   Rv0533c   OG5_129509   3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase I ... 401
M. tuberculosis   Rv2222c   OG5_127086   Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 401
M. tuberculosis   Rv1878   OG5_127086   Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) 401
M. tuberculosis   Rv2861c   OG5_126721   Methionine aminopeptidase MapB (map) (peptidase M) 401
M. tuberculosis   Rv3566c   OG5_131280   Arylamine N-acetyltransferase Nat (arylamine acetylase) 391
M. tuberculosis   Rv2225   OG5_129046   3-methyl-2-oxobutanoate hydroxymethyltransferase PanB 391
M. tuberculosis   Rv1007c   OG5_127468   Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 386
M. tuberculosis   Rv0014c   OG5_146588   Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 386
M. tuberculosis   Rv2428   OG5_126593   Alkyl hydroperoxide reductase C protein AhpC (alkyl hydroperoxidase C) 381
M. tuberculosis   Rv0764c   OG5_129288   Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lano ... 376
M. tuberculosis   Rv2392   OG5_129962   Probable 3'-phosphoadenosine 5'-phosphosulfate reductase CysH (PAPS reductase, t ... 366
M. tuberculosis   Rv3106   OG5_128406   NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 366
M. tuberculosis   Rv3248c   OG5_127233   Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adoh ... 366
M. tuberculosis   Rv2539c   OG5_130547   Shikimate kinase AroK (SK) 356
M. tuberculosis   Rv1256c   OG5_132455   Probable cytochrome P450 130 Cyp130 356
M. tuberculosis   Rv1094   OG5_237738   Possible acyl-[acyl-carrier protein] desaturase DesA2 (acyl-[ACP] desaturase) (s ... 356
M. tuberculosis   Rv0058   OG5_131890   Probable replicative DNA helicase DnaB 356
M. tuberculosis   Rv3607c   OG5_133572   Probable dihydroneopterin aldolase FolB (DHNA) 356
M. tuberculosis   Rv2965c   OG5_132912   Probable phosphopantetheine adenylyltransferase KdtB (pantetheine- phosphate ade ... 356
M. tuberculosis   Rv3465   OG5_132926   dTDP-4-dehydrorhamnose 3,5-epimerase RmlC (dTDP-4-keto-6-deoxyglucose 3,5-epimer ... 356
M. tuberculosis   Rv3778c   OG5_176182   Possible aminotransferase 356

Showing page 1 (records 1-25) of 91