Target list

Search results for query: PLoS NTD Query 7 (P. falciparum apicoplast)

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  • Score for genes in query #246 (Pfa ortholog in taxon (Pvi)): 50
  • Score for genes in query #242 (Pfa Pubmed): -20
  • Score for genes in query #240 (Pfa uploaded weighted list for molecular weight): 0
  • Score for genes in query #247 (Pfa any genetic validation): -50
  • Score for genes in query #239 (Pfa uploaded weighted list for Isoelectric point): 0
  • Score for genes in query #236 (Pfa any essentiality): 50
  • Score for genes in query #237 (Pfa all proteins): 1
  • Score for genes in query #245 (Pfa NOT in humans): 50
  • Score for genes in query #243 (Pfa PDB structures): -100
  • Score for genes in query #249 (Pfa assayable): 20
  • Score for genes in query #241 (Pfa compound desirability >0.2): 10
  • Score for genes in query #235 (Pfa Enzymes (EC + functional category)): 100
  • Score for genes in query #251 (Curated list of nuclear encode apicoplast targeted gene from Stuart Ralph): 1000
  • Score for genes in query #248 (Pfa Dindex >=0.4): 20
  • Score for genes in query #238 (Pfa expression in any RBC stage (80-100%)): 25
  • Score for genes in query #244 (Pfa Modbase structure models): 10

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

4804 records found | Showing page 2 of 193 (records 26-50) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
P. falciparum   PF3D7_1337200   OG5_129068   1-deoxy-D-xylulose 5-phosphate synthase 1211
P. falciparum   PF3D7_1304100   OG5_127375   DNA ligase I 1211
P. falciparum   PF3D7_1344600   OG5_127348   lipoyl synthase 1211
P. falciparum   PF3D7_1313200   OG5_127793   methionyl-tRNA formyltransferase, putative 1211
P. falciparum   PF3D7_0804400   OG5_156787   methionine aminopeptidase 1c, putative 1211
P. falciparum   PF3D7_0828200   OG5_127675   leucine--tRNA ligase, putative 1211
P. falciparum   PF3D7_0815900   OG5_135307   dihydrolipoyl dehydrogenase, apicoplast 1211
P. falciparum   PF3D7_1020800   OG5_134960   dihydrolipoamide acyltransferase component E2 1211
P. falciparum   PF3D7_1117500   OG5_127413   tyrosine--tRNA ligase 1211
P. falciparum   PF3D7_1124500   OG5_127216   pyruvate dehydrogenase E1 component subunit alpha 1211
P. falciparum   PF3D7_1307600   OG5_130460   DNA-directed RNA polymerase alpha chain, putative 1211
P. falciparum   PF3D7_1416800   OG5_160480   lysine--tRNA ligase, putative 1211
P. falciparum   PF3D7_1430700   OG5_126857   NADP-specific glutamate dehydrogenase 1211
P. falciparum   PF3D7_1440300   OG5_127486   porphobilinogen synthase 1211
P. falciparum   PF3D7_1443700   OG5_127254   dephospho-CoA kinase, putative 1211
P. falciparum   PF3D7_0215000   OG5_129177   acyl-CoA synthetase 1211
P. falciparum   PF3D7_0318800   OG5_162077   triosephosphate isomerase, putative 1211
P. falciparum   PF3D7_0416100   OG5_127466   glutamyl-tRNA(Gln) amidotransferase subunit A 1211
P. falciparum   PF3D7_0514300   OG5_167278   aspartate--tRNA ligase, putative 1211
P. falciparum   PF3D7_0604700   OG5_166095   glyoxalase I 1211
P. falciparum   PF3D7_0607300   OG5_127347   uroporphyrinogen III decarboxylase 1211
P. falciparum   PF3D7_0910800   OG5_126620   cytosolic Fe-S cluster assembly factor NBP35, putative 1211
P. falciparum   PF3D7_0914000   OG5_126865   pseudouridylate synthase, putative 1211
P. falciparum   PF3D7_1212000   OG5_126711   glutathione peroxidase-like thioredoxin peroxidase 1211
P. falciparum   PF3D7_1232000   OG5_167491   phenylalanine--tRNA ligase 1211

Showing page 2 (records 26-50) of 193