Target list

Search results for query: PLoS NTD Query 5 (M. tuberculosis)

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  • Score for genes in query #70 (Mtb dindex >=0.6): 35
  • Score for genes in query #68 (Mtb any genetic validation): 50
  • Score for genes in query #64 (Mtb PDB): 50
  • Score for genes in query #65 (Mtb modbase): 30
  • Score for genes in query #72 (Mtb assayable): 35
  • Score for genes in query #74 (Mtb all proteins): 1
  • Score for genes in query #62 (Mtb mwt <100kDa): 20
  • Score for genes in query #69 (Mtb any essentiality evidence): 50
  • Score for genes in query #71 (Mtb Compd desirability >0.3): 35
  • Score for genes in query #61 (Mtb Pubmed): 35
  • Score for genes in query #63 (Mtb no TM domain): 20
  • Score for genes in query #66 (Mtb not in humans): 25
  • Score for genes in query #67 (Mtb in Mle): 25
  • Score for genes in query #60 (Mtb enz (EC + func. Categ.)): 100

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

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2253 records found | Showing page 2 of 91 (records 26-50) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
M. tuberculosis   Rv1612   OG5_128016   Tryptophan synthase, beta subunit TrpB 356
M. tuberculosis   Rv2523c   OG5_130884   holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pant ... 341
M. tuberculosis   Rv1538c   OG5_127035   Probable L-aparaginase AnsA 341
M. tuberculosis   Rv2552c   OG5_128849   Probable shikimate 5-dehydrogenase AroE (5-dehydroshikimate reductase) 341
M. tuberculosis   Rv3708c   OG5_128664   Aspartate-semialdehyde dehydrogenase Asd (ASA dehydrogenase) (ASADH) (aspartic s ... 341
M. tuberculosis   Rv0363c   OG5_131639   Probable fructose-bisphosphate aldolase Fba 341
M. tuberculosis   Rv1837c   OG5_159543   Malate synthase G GlcB 341
M. tuberculosis   Rv3490   OG5_129327   Alpha, alpha-trehalose-phosphate synthase [UDP-forming] OtsA (trehalose-6-phosph ... 341
M. tuberculosis   Rv3601c   OG5_134769   Probable aspartate 1-decarboxylase precursor PanD (aspartate alpha-decarboxylase ... 341
M. tuberculosis   Rv2702   OG5_164841   Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase) 341
M. tuberculosis   Rv0334   OG5_131815   Alpha-D-glucose-1-phosphate thymidylyltransferase RmlA (dTDP-glucose synthase) ( ... 341
M. tuberculosis   Rv3457c   OG5_130460   Probable DNA-directed RNA polymerase (alpha chain) RpoA (transcriptase alpha cha ... 341
M. tuberculosis   Rv1448c   OG5_152385   Probable transaldolase Tal 341
M. tuberculosis   Rv2773c   OG5_131385   Dihydrodipicolinate reductase DapB (DHPR) 336
M. tuberculosis   Rv2130c   OG5_237682   Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 336
M. tuberculosis   Rv1743   OG5_142551   Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) ... 336
M. tuberculosis   Rv0902c   OG5_127115   Two component sensor histidine kinase PrrB 336
M. tuberculosis   Rv1310   OG5_127099   Probable ATP synthase beta chain AtpD 331
M. tuberculosis   Rv1092c   OG5_141174   Probable pantothenate kinase CoaA (pantothenic acid kinase) 331
M. tuberculosis   Rv2447c   OG5_126889   Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate syn ... 331
M. tuberculosis   Rv2918c   OG5_138771   Probable [protein-PII] uridylyltransferase GlnD (PII uridylyl- transferase) (uri ... 331
M. tuberculosis   Rv2995c   OG5_126870   Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3 ... 331
M. tuberculosis   Rv2610c   OG5_144421   Alpha-mannosyltransferase PimA 331
M. tuberculosis   Rv2925c   OG5_127728   Probable ribonuclease III Rnc (RNase III) 331
M. tuberculosis   Rv1689   OG5_127413   Probable tyrosyl-tRNA synthase TyrS (TYRRS) 331

Showing page 2 (records 26-50) of 91