Target list

Search results for query: PLoS NTD Query 8 (T. cruzi)

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  • Score for genes in query #11 (tcruzi not in humans): 80
  • Score for genes in query #9 (low molecular weight (< 100 kDa)): 25
  • Score for genes in query #3 (3D structure): 10
  • Score for genes in query #15 (tcruzi assay available): 30
  • Score for genes in query #2 (is enzyme): 20
  • Score for genes in query #8 (bibrefs): 25
  • Score for genes in query #14 (tcruzi reagent availability): 30
  • Score for genes in query #10 (tcruzi all genes): 1
  • Score for genes in query #7 (druggability > .5): 60
  • Score for genes in query #5 (any evidence of essentiality): 50
  • Score for genes in query #13 (tcruzi not in tbrucei): 150
  • Score for genes in query #1 (amastigote expression >= 2 spectra / 2 peptides): 20
  • Score for genes in query #4 (3D model): 10
  • Score for genes in query #12 (tcruzi in leish): 90
  • Score for genes in query #6 (> 3 paralogs): -30
  • Imported: from "tcruzi targets shared with leishmania, absent in tbrucei", posted by Fernan Aguero

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

18628 records found | Showing page 746 of 746 (records 18626-18628) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
T. cruzi   TcCLB.510073.75   OG5_134831   hypothetical protein, conserved -4
T. cruzi   TcCLB.509399.150   OG5_134831   hypothetical protein, conserved -4
T. cruzi   TcCLB.511621.90   OG5_128665   esterase, putative -4

Showing page 746 (records 18626-18628) of 746