Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.
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Organism | Name | Ortholog group | Product |
---|---|---|---|
P. falciparum | PF3D7_0211400 | OG5_129509 | beta-ketoacyl-ACP synthase III |
P. falciparum | PF3D7_0312400 | OG5_126888 | glycogen synthase kinase 3 |
P. falciparum | PF3D7_0322000 | OG5_126792 | peptidyl-prolyl cis-trans isomerase |
P. falciparum | PF3D7_0417200 | OG5_127385 | bifunctional dihydrofolate reductase-thymidylate synthase |
P. falciparum | PF3D7_0520900 | OG5_127233 | adenosylhomocysteinase |
P. falciparum | PF3D7_0603300 | OG5_127289 | dihydroorotate dehydrogenase |
P. falciparum | PF3D7_0615100 | OG5_130466 | enoyl-acyl carrier reductase |
P. falciparum | PF3D7_0810800 | OG5_128803 | hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase |
P. falciparum | PF3D7_0922900 | OG5_126618 | 3-oxoacyl-[acyl-carrier-protein] reductase |
P. falciparum | PF3D7_0923800 | OG5_126785 | thioredoxin reductase |
P. falciparum | PF3D7_1008900 | OG5_126762 | adenylate kinase |
P. falciparum | PF3D7_1012400 | OG5_127374 | hypoxanthine-guanine phosphoribosyltransferase |
P. falciparum | PF3D7_1014400 | OG5_141009 | MO15-related protein kinase |
P. falciparum | PF3D7_1029600 | OG5_127245 | adenosine deaminase |
P. falciparum | PF3D7_1033100 | OG5_126750 | S-adenosylmethionine decarboxylase/ornithine decarboxylase |
P. falciparum | PF3D7_1113700 | OG5_127627 | glyoxalase I |
P. falciparum | PF3D7_1127100 | OG5_126992 | deoxyuridine 5'-triphosphate nucleotidohydrolase |
P. falciparum | PF3D7_1129000 | OG5_127074 | spermidine synthase |
P. falciparum | PF3D7_1324900 | OG5_126911 | L-lactate dehydrogenase |
P. falciparum | PF3D7_1407800 | OG5_126885 | plasmepsin IV |
P. falciparum | PF3D7_1407900 | OG5_126885 | plasmepsin I |
P. falciparum | PF3D7_1408000 | OG5_126885 | plasmepsin II |
P. falciparum | PF3D7_1419800 | OG5_126785 | glutathione reductase |
P. falciparum | PF3D7_1436600 | OG5_127599 | cGMP-dependent protein kinase |
P. falciparum | PF3D7_1439900 | OG5_127002 | triosephosphate isomerase |