Target list

Search results for query: T. brucei targets - composite weighted query (DSR)

  • Score for genes in query #33 (T. brucei no TM domains): 20
  • Score for genes in query #34 (T. brucei published): 35
  • Score for genes in query #6 (T. brucei, NOT human): 25
  • Score for genes in query #4 (T. brucei models): 30
  • Score for genes in query #30 (Compound desirability (>0.3)): 35
  • Score for genes in query #35 (T. brucei lethal (KO or KD)): 50
  • Score for genes in query #36 (T. brucei 3D structures): 50
  • Score for genes in query #5 (Present in all TriTryps): 25
  • Score for genes in query #27 (T. brucei <100kDa): 20
  • Score for genes in query #7 (Essential (in any organism)): 40
  • Score for genes in query #2 (T. brucei enzymes): 100
  • Score for genes in query #29 (Druggability precedent (>0.6)): 35

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

8361 records found | Showing page 2 of 335 (records 26-50) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
T. brucei   Tb927.8.7110   OG5_142254   Serine/threonine-protein kinase NEK12.1, putative 325
T. brucei   Tb427.10.5940     No group (OTHER) NEK family, HsNEK1-like 325
T. brucei   Tb927.10.13490   OG5_146626   CAMK/CAMKL family protein kinase, putative 325
T. brucei   Tb927.7.1900   OG5_133587   cdc2-related protein kinase 7, putative 325
T. brucei   Tb927.3.2440   OG5_129514   AGC essential kinase 1 325
T. brucei   Tb927.11.11110   OG5_148164   Serine/threonine-protein kinase NEK20, putative 325
T. brucei   Tb927.9.12880   OG5_162395   STE20-like serine/threonine-protein kinase 2, putative 325
T. brucei   Tb927.7.2750   OG5_148620   calcium/calmodulin-dependent protein kinase, putative 325
T. brucei   Tb927.11.15010   OG5_154673   Serine/threonine-protein kinase NEK21, putative 325
T. brucei   Tb11.v5.0474   OG5_154473   protein kinase, putative 325
T. brucei   Tb927.10.5930   OG5_135887   NEK family Serine/threonine-protein kinase, putative 325
T. brucei   Tb927.3.3190   OG5_144700   Serine/threonine-protein kinase NEK7, putative 325
T. brucei   Tb927.5.4430   OG5_145848   calcium/calmodulin-dependent protein kinase, putative 325
T. brucei   Tb927.11.6690   OG5_145884   NEK family Serine/threonine-protein kinase, putative 325
T. brucei   Tb927.7.7360   OG5_148260   cdc2-related kinase 2 325
T. brucei   Tb927.10.2040   OG5_145951   STE group serine/threonine-protein kinase, putative 325
T. brucei   Tb927.4.5310   OG5_142254   Repressor of differentiation kinase 2 325
T. brucei   Tb927.8.6810   OG5_141398   STE/STE11 serine/threonine-protein kinase, putative 325
T. brucei   Tb11.v5.0387   OG5_154593   cell-division control protein 2 homolog 6, putative 325
T. brucei   Tb927.8.1670   OG5_144303   Serine/threonine-protein kinase NEK14, putative 325
T. brucei   Tb927.11.7160   OG5_148498   cdc2-related kinase 8, putative 325
T. brucei   Tb927.6.1780   OG5_150012   mitogen activated protein kinase 4, putative 325
T. brucei   Tb927.8.6930   OG5_139463   serine/threonine-protein kinase NRKB, putative 325
T. brucei   Tb927.4.5390   OG5_139463   serine/threonine-protein kinase NrkA 325
T. brucei   Tb927.3.3920   OG5_153007   Aurora kinase 2, putative 325

Showing page 2 (records 26-50) of 335