Target list

Search results for query: T. cruzi ranked list of targets

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  • Score for genes in query #26 (ortholog in T. brucei): 20
  • Score for genes in query #23 (not in human): 40
  • Score for genes in query #28 (strucural model available): 15
  • Score for genes in query #24 (significant druggability): 30
  • Score for genes in query #27 (single copy gene): 20
  • Score for genes in query #25 (essentiality evidence in any specie): 20
  • Score for genes in query #22 (enzyme): 30
  • Score for genes in query #29 (assayable): 15

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

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18619 records found | Showing page 1 of 745 (records 1-25) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
T. cruzi   TcCLB.510773.20   OG5_128905   Vacuolar proton pyrophosphatase 1, putative 170
T. cruzi   TcCLB.506247.330   OG5_129051   2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative 160
T. cruzi   TcCLB.507037.50   OG5_153663   exonuclease, putative 160
T. cruzi   TcCLB.508181.140   OG5_128875   inorganic pyrophosphatase, putative 160
T. cruzi   TcCLB.506445.60   OG5_128755   mitochondrial DNA topoisomerase II, putative 160
T. cruzi   TcCLB.508153.820   OG5_128875   inorganic pyrophosphatase, putative 160
T. cruzi   TcCLB.508707.64   OG5_153663   exonuclease, putative 160
T. cruzi   TcCLB.508277.370   OG5_128755   mitochondrial DNA topoisomerase II, putative 160
T. cruzi   TcCLB.511385.30   OG5_128905   vacuolar-type proton translocating pyrophosphatase 1 155
T. cruzi   TcCLB.506195.80   OG5_126762   adenylate kinase, putative 150
T. cruzi   TcCLB.508693.20   OG5_127702   DNA topoisomerase IB, large subunit, putative 150
T. cruzi   TcCLB.507883.80   OG5_126762   adenylate kinase, putative 150
T. cruzi   TcCLB.509203.70   OG5_127113   DNA topoisomerase II, putative 150
T. cruzi   TcCLB.511717.90   OG5_127555   phosphomannose isomerase, putative 150
T. cruzi   TcCLB.506831.40   OG5_127955   3-hydroxy-3-methylglutaryl-CoA reductase 150
T. cruzi   TcCLB.509167.20   OG5_127955   3-hydroxy-3-methylglutaryl-CoA reductase, putative 150
T. cruzi   TcCLB.511321.23   OG5_127381   cytidine deaminase-like protein 150
T. cruzi   TcCLB.503555.30   OG5_126785   trypanothione reductase, putative 150
T. cruzi   TcCLB.509153.90   OG5_127385   dihydrofolate reductase-thymidylate synthase 150
T. cruzi   TcCLB.503677.10   OG5_127555   phosphomannose isomerase, putative 150
T. cruzi   TcCLB.508951.20   OG5_126743   hexokinase, putative 150
T. cruzi   TcCLB.507031.120   OG5_126721   metallo- peptidase, Clan MG, Family M24 150
T. cruzi   TcCLB.508699.10   OG5_127113   DNA topoisomerase II, putative 150
T. cruzi   TcCLB.509453.50   OG5_127141   serine/threonine-protein phosphatase 150
T. cruzi   TcCLB.504111.20   OG5_126721   metallo- peptidase, Clan MG, Family M24 150

Showing page 1 (records 1-25) of 745