Target list

Search results for query: T. brucei targets - composite weighted query (DSR)

  • Score for genes in query #6 (T. brucei, NOT human): 25
  • Score for genes in query #2 (T. brucei enzymes): 100
  • Score for genes in query #34 (T. brucei published): 35
  • Score for genes in query #36 (T. brucei 3D structures): 50
  • Score for genes in query #35 (T. brucei lethal (KO or KD)): 50
  • Score for genes in query #4 (T. brucei models): 30
  • Score for genes in query #27 (T. brucei <100kDa): 20
  • Score for genes in query #5 (Present in all TriTryps): 25
  • Score for genes in query #30 (Compound desirability (>0.3)): 35
  • Score for genes in query #29 (Druggability precedent (>0.6)): 35
  • Score for genes in query #7 (Essential (in any organism)): 40
  • Score for genes in query #33 (T. brucei no TM domains): 20

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

8361 records found | Showing page 1 of 335 (records 1-25) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
T. brucei   Tb927.7.3360   OG5_127590   farnesyl pyrophosphate synthase 405
T. brucei   Tb927.1.700   OG5_126776   phosphoglycerate kinase 370
T. brucei   Tb927.10.2890   OG5_126698   enolase 370
T. brucei   Tb11.v5.0531   OG5_127143   fructose-bisphosphate aldolase, glycosomal, putative 370
T. brucei   Tb927.11.2730   OG5_126853   UDP-galactose 4-epimerase 365
T. brucei   Tb927.6.2030   OG5_140087   STE/STE11 serine/threonine-protein kinase, putative 365
T. brucei   Tb927.11.4700   OG5_126583   prostaglandin f synthase 355
T. brucei   Tb927.6.560   OG5_127800   cysteine peptidase C (CPC) 355
T. brucei   Tb927.10.14240   OG5_127597   N-myristoyltransferase 355
T. brucei   Tb927.9.5590   OG5_128755   DNA topoisomerase ii 345
T. brucei   Tb927.3.1380   OG5_127099   ATP synthase subunit beta, mitochondrial 340
T. brucei   Tb927.8.5950   OG5_144825   mitogen-activated protein kinase kinase 4, putative 340
T. brucei   Tb11.v5.0718   OG5_126888   protein kinase, putative 340
T. brucei   Tb927.10.4990   OG5_126712   cdc2-related kinase 3 340
T. brucei   Tb927.4.1080   OG5_127237   V-type ATPase, A subunit, putative 340
T. brucei   Tb927.7.6220   OG5_131734   calcium/calmodulin-dependent protein kinase, putative 340
T. brucei   Tb927.11.3140   OG5_127439   dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 340
T. brucei   Tb927.10.1070   OG5_126712   cdc2-related kinase 1 340
T. brucei   Tb927.8.2210   OG5_133937   pteridine reductase 1 340
T. brucei   Tb927.11.150   OG5_126617   receptor-type adenylate cyclase GRESAG 4, putative 340
T. brucei   Tb11.v5.0671   OG5_126748   protein kinase A catalytic subunit, putative 340
T. brucei   Tb927.9.12110   OG5_127175   6-phosphogluconate dehydrogenase, decarboxylating 335
T. brucei   Tb927.6.4280   OG5_126628   glyceraldehyde 3-phosphate dehydrogenase, glycosomal 335
T. brucei   Tb927.6.4300   OG5_126628   glyceraldehyde 3-phosphate dehydrogenase, glycosomal 335
T. brucei   Tb927.6.4590   OG5_128638   glutamyl-tRNA synthetase, putative 330

Showing page 1 (records 1-25) of 335