Target list

Search results for query: Weighted ranking of B. malayi targets for PLOS-NTD

You can Modify weights (moves query to your history allowing re-weight functionality) to match your needs

  • Score for genes in query #10 (Bma druggable precedence by similarity to starlite targets): 30
  • Score for genes in query #304 (Bma - sterile in Cel): 20
  • Score for genes in query #312 (Bma any essentiality): 5
  • Score for genes in query #306 (Bma pubmed): 2
  • Score for genes in query #309 (Bma - growth defect in Cel): 20
  • Score for genes in query #305 (Bma modbase): 2
  • Score for genes in query #310 (Bma - larval/adult lethal/arrest in Cel): 40
  • Score for genes in query #317 (Bma all proteins): 1
  • Score for genes in query #308 (Bma - embryonic lethal/arrest in Cel): 30
  • Score for genes in query #311 (Bma - morphology defect in Cel): 20
  • Score for genes in query #315 (Bma in PDB): 5
  • Score for genes in query #314 (Bma any EC): 10
  • Score for genes in query #316 (Bma assayable): 5
  • Score for genes in query #307 (Bma in Cel): 10

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

11305 records found | Showing page 1 of 453 (records 1-25) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
B. malayi   Bm1_35945   OG5_128520   Protein kinase domain containing protein 190
B. malayi   Bm1_25205   OG5_127407   leucyl-tRNA synthetase 188
B. malayi   Bm1_46445   OG5_126705   vacuolar proton pump 188
B. malayi   Bm1_31340   OG5_126705   vacuolar proton pump 188
B. malayi   Bm1_44630   OG5_126812   oxidoreductase, short chain dehydrogenase/reductase family protein 178
B. malayi   Bm1_20715   OG5_126605   tubulin alpha-2 chain 178
B. malayi   Bm1_28835   OG5_128511   Transcription initiation factor IIA, gamma subunit, helical domain containing pr ... 178
B. malayi   Bm1_32860   OG5_126723   Valyl-tRNA synthetase 178
B. malayi   Bm1_39900   OG5_131257   Sex muscle abnormal protein 5 178
B. malayi   Bm1_38680   OG5_126605   tubulin alpha chain - mouse 178
B. malayi   Bm1_14145   OG5_127382   protein phosphatase PP2A regulatory subunit 178
B. malayi   Bm1_44205   OG5_126705   V-type ATPase 116kDa subunit family protein 178
B. malayi   Bm1_55400   OG5_126605   Tubulin alpha-2 chain 178
B. malayi   Bm1_43680   OG5_127998   T-complex protein 1, alpha subunit 178
B. malayi   Bm1_46210   OG5_128263   Protein kinase domain containing protein 178
B. malayi   Bm1_25035   OG5_126605   Tubulin alpha-2 chain 178
B. malayi   Bm1_48675   OG5_131088   GTP-binding regulatory protein Gs alpha-S chain, putative 178
B. malayi   Bm1_30260   OG5_126605   Tubulin alpha chain 178
B. malayi   Bm1_30720   OG5_127549   KE2 family protein 178
B. malayi   Bm1_10280   OG5_126720   transketolase 173
B. malayi   Bm1_54155   OG5_126745   Probable dimethyladenosine transferase 170
B. malayi   Bm1_20815   OG5_132787   integrin-linked kinase 170
B. malayi   Bm1_17330   OG5_126927   succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 168
B. malayi   Bm1_50960   OG5_127237   vacuolar ATP synthase catalytic subunit A, osteoclast isoform 168
B. malayi   Bm1_41830   OG5_126799   Alanyl-tRNA synthetase 168

Showing page 1 (records 1-25) of 453