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Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.
2253 records found | Showing page 1 of 91 (records 1-25) | Number of records to display | Find orthologs in
Organism | Name | Ortholog group | Product | Weight |
---|---|---|---|---|
M. tuberculosis | Rv1484 | OG5_130466 | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl ... | 511 |
M. tuberculosis | Rv2537c | OG5_132746 | 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) | 406 |
M. tuberculosis | Rv2763c | OG5_128410 | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 406 |
M. tuberculosis | Rv3602c | OG5_129569 | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activatin ... | 406 |
M. tuberculosis | Rv0533c | OG5_129509 | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase I ... | 401 |
M. tuberculosis | Rv2222c | OG5_127086 | Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) | 401 |
M. tuberculosis | Rv1878 | OG5_127086 | Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) | 401 |
M. tuberculosis | Rv2861c | OG5_126721 | Methionine aminopeptidase MapB (map) (peptidase M) | 401 |
M. tuberculosis | Rv3566c | OG5_131280 | Arylamine N-acetyltransferase Nat (arylamine acetylase) | 391 |
M. tuberculosis | Rv2225 | OG5_129046 | 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB | 391 |
M. tuberculosis | Rv1007c | OG5_127468 | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 386 |
M. tuberculosis | Rv0014c | OG5_146588 | Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) | 386 |
M. tuberculosis | Rv2428 | OG5_126593 | Alkyl hydroperoxide reductase C protein AhpC (alkyl hydroperoxidase C) | 381 |
M. tuberculosis | Rv0764c | OG5_129288 | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lano ... | 376 |
M. tuberculosis | Rv2392 | OG5_129962 | Probable 3'-phosphoadenosine 5'-phosphosulfate reductase CysH (PAPS reductase, t ... | 366 |
M. tuberculosis | Rv3106 | OG5_128406 | NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) | 366 |
M. tuberculosis | Rv3248c | OG5_127233 | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adoh ... | 366 |
M. tuberculosis | Rv2539c | OG5_130547 | Shikimate kinase AroK (SK) | 356 |
M. tuberculosis | Rv1256c | OG5_132455 | Probable cytochrome P450 130 Cyp130 | 356 |
M. tuberculosis | Rv1094 | OG5_237738 | Possible acyl-[acyl-carrier protein] desaturase DesA2 (acyl-[ACP] desaturase) (s ... | 356 |
M. tuberculosis | Rv0058 | OG5_131890 | Probable replicative DNA helicase DnaB | 356 |
M. tuberculosis | Rv3607c | OG5_133572 | Probable dihydroneopterin aldolase FolB (DHNA) | 356 |
M. tuberculosis | Rv2965c | OG5_132912 | Probable phosphopantetheine adenylyltransferase KdtB (pantetheine- phosphate ade ... | 356 |
M. tuberculosis | Rv3465 | OG5_132926 | dTDP-4-dehydrorhamnose 3,5-epimerase RmlC (dTDP-4-keto-6-deoxyglucose 3,5-epimer ... | 356 |
M. tuberculosis | Rv3778c | OG5_176182 | Possible aminotransferase | 356 |