Target list

Search results for query: Union of (49, 50, 52, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 67, 68, 69, 70, 71, 72, 73, 81)

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  • Score for genes in query #57 (Assayability - Soluble): 7
  • Score for genes in query #55 (tcr doesn't have ortholog in mammals): 12
  • Score for genes in query #81 (nucleotide-diversity-normalized): var
  • Score for genes in query #73 (has 3D structure(s)): 20
  • Score for genes in query #50 (tcr expression trypos-amas 1,5 fold 0.8 confidence): 12
  • Score for genes in query #56 (Assayability - Assay Available): 7
  • Score for genes in query #49 ( tcr expression epis-amas 1,5 fold 0.8 confidence): 12
  • Score for genes in query #71 (is enzyme): 15
  • Score for genes in query #59 (tcr MW < 100 kDa): 9
  • Score for genes in query #60 (has >= 1 TM domain): -3
  • Score for genes in query #52 (tcr has ortholog in kinetoplastida): 9
  • Score for genes in query #64 (has EC number): 9
  • Score for genes in query #68 (ortholog essential in M. tuberculosis): 12
  • Score for genes in query #67 (ortholog essential in E. coli): 12
  • Score for genes in query #72 (has 3D model(s)): 20
  • Score for genes in query #61 (tcr > 2 paralogs): -18
  • Score for genes in query #58 (Pubmed): 12
  • Score for genes in query #69 (ortholog essential in S. cerevisiae): 12
  • Score for genes in query #62 (has GPI anchor signal): -3
  • Score for genes in query #70 (ortholog in C. elegans has 'embryonic arrest' RNAi phenotype): 12
  • Score for genes in query #63 (has Signal Peptide): -3

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

18625 records found | Showing page 1 of 745 (records 1-25) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
T. cruzi   TcCLB.511025.110   OG5_126968   dihydrolipoyl dehydrogenase, putative 226
T. cruzi   TcCLB.509153.90   OG5_127385   dihydrofolate reductase-thymidylate synthase 219
T. cruzi   TcCLB.504105.30   OG5_126637   DNA-directed RNA polymerase III subunit C1, putative 217
T. cruzi   TcCLB.510101.50   OG5_129288   Lanosterol 14-alpha demethylase 209
T. cruzi   TcCLB.509561.120   OG5_126941   deaminase, putative 207
T. cruzi   TcCLB.511717.90   OG5_127555   phosphomannose isomerase, putative 196
T. cruzi   TcCLB.511229.50   OG5_127233   S-adenosylhomocysteine hydrolase, putative 195
T. cruzi   TcCLB.484299.10     No group trypanothione reductase, putative 194
T. cruzi   TcCLB.510329.280   OG5_155824   protein farnesyltransferase alpha subunit, putative 192
T. cruzi   TcCLB.511281.60   OG5_126685   pyruvate kinase 2, putative 192
T. cruzi   TcCLB.508175.160   OG5_143192   deoxyuridine triphosphatase, putative 191
T. cruzi   TcCLB.510575.180   OG5_126886   adenylate kinase, putative 191
T. cruzi   TcCLB.508699.10   OG5_127113   DNA topoisomerase II, putative 191
T. cruzi   TcCLB.510889.221   OG5_126980   glucose-6-phosphate isomerase, glycosomal, putative 190
T. cruzi   TcCLB.506445.60   OG5_128755   mitochondrial DNA topoisomerase II, putative 190
T. cruzi   TcCLB.510445.50   OG5_126734   S-adenosylmethionine synthetase, putative 189
T. cruzi   TcCLB.510443.9   OG5_126723   valyl-tRNA synthetase, putative 189
T. cruzi   TcCLB.508153.820   OG5_128875   inorganic pyrophosphatase, putative 189
T. cruzi   TcCLB.504069.10   OG5_127791   proteasome alpha 2 subunit, putative 188
T. cruzi   TcCLB.509429.110   OG5_127762   proteasome beta-1 subunit, putative 187
T. cruzi   TcCLB.508441.20   OG5_128435   Phosphoenolpyruvate carboxykinase [ATP], glycosomal 187
T. cruzi   TcCLB.511181.50   OG5_127023   mitochondrial processing peptidase, beta subunit, putative 185
T. cruzi   TcCLB.507241.30   OG5_128330   arginine kinase 184
T. cruzi   TcCLB.506477.20   OG5_127665   vesicular-fusion protein nsf, putative 184
T. cruzi   TcCLB.509207.90   OG5_126801   pyrroline-5-carboxylate reductase, putative 184

Showing page 1 (records 1-25) of 745