Gene links: No gene identifiers were provided.

Description:
The mitochondrial ATP synthase complex is essential in bloodstream form T. brucei (1). In contrast to its counterpart in the mammalian host, the trypanosome enzyme functions in reverse (i.e. ATP hydrolase activity) to pump protons out of the mitochondrial matrix, thus generating the essential mitochondrial membrane potential. Inhibitors specific for the hydrolase direction (i.e. not affecting the synthase direction) would be expected to be potent and specific trypanocides. Such inhibitors are currently under development in the pharmaceutical industry as cardioprotective agents (2), raising the possibility of a piggybacking approach. (1) Schnaufer et al. (2005). EMBO J. 24 (23): 4029-4040. (2) Atwal et al. (2004) J. Med. Chem. 47(5):1081-4 Target ID: geneDB number = multiprotein complex (e.g. Tb927.7.7420, Tb927.3.1380) EC number (if enzyme) = 3.6.3.14 target name = ATP synthase Assay: Assay exists but not yet in microtitre plate format Availability: No useful expression system is available Activity: Significant (= 1 full time person)

Target ID: geneDB number = multiprotein complex (e.g. Tb927.7.7420, Tb927.3.1380) EC number (if enzyme) = 3.6.3

Validation: Genetic OR chemical evidence

Assay status: Assay exists but not yet in microtitre plate format

Availability: No useful expression system is available

Activity: Significant (>= 1 full time person)

No references provided.