Detailed view for PF3D7_1303800

Basic information

TDR Targets ID: 101
Plasmodium falciparum, conserved Plasmodium protein, unknown function
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.337 | Length (AA): 9271 | MW (Da): 1111791 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0005086   ARF guanyl-nucleotide exchange factor activity  
GO:0003777   microtubule motor activity  
GO:0005488   binding  
GO:0032012   regulation of ARF protein signal transduction  
GO:0007018   microtubule-based movement  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 17 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7403 8683 1ej6 (A) 6 1268 13.00 0 0.82 -0.31 1.58
390 648 2za2 (A) 6 263 24.00 0.61 0.92 0.0315366 0.73
1656 2550 2qiz (A) 0 932 13.00 0 0.99 -0.0347624 0.8
3884 4699 2q5d (B) 62 871 10.00 0 0.5 -0.113284 1.11
4468 5448 3icq (T) 21 969 11.00 0 0.99 0.0255138 0.91
5872 6280 4fp7 (B) 50 471 14.00 0 1 0.0328161 0.11
6346 7239 2fge (A) 83 983 8.00 0 0.01 -0.12187 1.22
6762 7687 3gb8 (A) 84 1043 11.00 0 1 0.0565814 0.57
8213 9009 3s5k (A) 139 963 25.00 0.0019 0.93 -0.066433 1.9
9033 9246 4v3d (A) 500 715 11.00 0 0 0.0147827 -0.41
383 1174 5czz (A) 119 958 22.00 0.83 1 -0.0770194 1.99
3121 3487 4ams (A) 0 353 16.00 0 0.81 -0.117765 1.16
3126 4377 4oo8 (D) 45 1355 16.00 0 0.89 -0.083465 1.66
4196 4937 2x19 (B) 148 940 10.00 0 0.85 0.00603993 0.28
4440 5417 3icq (T) 21 969 11.00 0 0.99 0.01872 0.94
8132 8928 3s5k (A) 139 963 25.00 0.0019 0.93 -0.0644753 1.9
8952 9165 4v3d (A) 500 715 11.00 0 0 0.00458618 -0.33

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Sporozoite, Male Gametocyte. Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile gametocyte, early schizont, late schizont, Female Gametocyte. PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, Ring. Otto TD Zanghi G
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_154801)

Species Accession Gene Product
Plasmodium berghei PBANKA_1402300   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1303800   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_1404000   peptidase, putative
Plasmodium vivax PVX_122030   hypothetical protein, conserved
Plasmodium yoelii PY07055   hypothetical protein
Plasmodium yoelii PY01943   hypothetical protein
Plasmodium yoelii PY03740   hypothetical protein
Plasmodium yoelii PY00456   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1303800 (Plasmodium falciparum), conserved Plasmodium protein, unknown function
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