pI: 5.3548 |
Length (AA): 370 |
MW (Da): 41748 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
26 | 355 | 1jl0 (A) | 5 | 328 | 28.00 | 0 | 1 | 1.26519 | -0.81 |
87 | 357 | 5tvm (B) | 87 | 357 | 99.99 | 0 | 1 | 1.94153 | -1.17 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128279)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G18930 | S-adenosylmethionine decarboxylase |
Arabidopsis thaliana | AT3G02470 | conserved peptide upstream open reading frame 9 |
Arabidopsis thaliana | AT3G25570 | S-adenosylmethionine decarboxylase |
Arabidopsis thaliana | AT5G15950 | S-adenosylmethionine decarboxylase proenzyme 2 |
Brugia malayi | Bm1_26830 | S-adenosylmethionine decarboxylase proenzyme |
Candida albicans | CaO19.8199 | S-adenosylmethionine decarboxylase |
Candida albicans | CaO19.568 | S-adenosylmethionine decarboxylase |
Caenorhabditis elegans | CELE_F47G4.7 | Protein SMD-1 |
Dictyostelium discoideum | DDB_G0275567 | S-adenosylmethionine decarboxylase |
Drosophila melanogaster | Dmel_CG5029 | S-adenosylmethionine decarboxylase |
Echinococcus granulosus | EgrG_000713300 | S adenosylmethionine decarboxylase proenzyme |
Echinococcus multilocularis | EmuJ_000713300 | S adenosylmethionine decarboxylase proenzyme |
Homo sapiens | ENSG00000123505 | adenosylmethionine decarboxylase 1 |
Leishmania braziliensis | LbrM.30.3100 | S-adenosylmethionine decarboxylase |
Leishmania donovani | LdBPK_303150.1 | S-adenosylmethionine decarboxylase |
Leishmania infantum | LinJ.30.3150 | S-adenosylmethionine decarboxylase |
Leishmania major | LmjF.30.3110 | S-adenosylmethionine decarboxylase |
Leishmania mexicana | LmxM.29.3110 | S-adenosylmethionine decarboxylase proenzyme |
Loa Loa (eye worm) | LOAG_06310 | S-adenosylmethionine decarboxylase proenzyme |
Mus musculus | ENSMUSG00000075232 | S-adenosylmethionine decarboxylase 1 |
Mus musculus | ENSMUSG00000063953 | S-adenosylmethionine decarboxylase 2 |
Oryza sativa | 4336294 | Os04g0498600 |
Oryza sativa | 4347103 | Os09g0424300 |
Oryza sativa | 4329955 | Os02g0611200 |
Saccharomyces cerevisiae | YOL052C | adenosylmethionine decarboxylase SPE2 |
Schmidtea mediterranea | mk4.011284.00 | S-adenosylmethionine decarboxylase proenzyme |
Schmidtea mediterranea | mk4.012677.00 | S-adenosylmethionine decarboxylase proenzyme |
Schmidtea mediterranea | mk4.004908.00 | S-adenosylmethionine decarboxylase proenzyme |
Schmidtea mediterranea | mk4.012519.01 | S-adenosylmethionine decarboxylase proenzyme |
Schmidtea mediterranea | mk4.003329.11 | S-adenosylmethionine decarboxylase proenzyme |
Trypanosoma brucei gambiense | Tbg972.6.4230 | S-adenosylmethionine decarboxylase |
Trypanosoma brucei | Tb927.6.4410 | S-adenosylmethionine decarboxylase |
Trypanosoma brucei | Tb927.6.4460 | S-adenosylmethionine decarboxylase |
Trypanosoma brucei | Tb11.v5.0903 | S-adenosylmethionine decarboxylase proenzyme, putative |
Trypanosoma congolense | TcIL3000_6_3880 | S-adenosylmethionine decarboxylase proenzyme, putative |
Trypanosoma cruzi | TcCLB.504257.30 | S-adenosylmethionine decarboxylase proenzyme, putative |
Trypanosoma cruzi | TcCLB.509167.120 | S-adenosylmethionine decarboxylase proenzyme, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.4410 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.4410 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.4410 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.4410 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.6
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Rattus norvegicus | S-adenosylmethionine decarboxylase 1 | Compounds | References |
Homo sapiens | adenosylmethionine decarboxylase 1 | Compounds | References |
31 literature references were collected for this gene.