pI: 5.9793 |
Length (AA): 487 |
MW (Da): 53168 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_130726)
Species | Accession | Gene Product |
---|---|---|
Echinococcus granulosus | EgrG_000603100 | tubulin epsilon chain |
Echinococcus multilocularis | EmuJ_000603100 | tubulin epsilon chain |
Giardia lamblia | GL50803_6336 | Epsilon tubulin |
Homo sapiens | ENSG00000074935 | tubulin, epsilon 1 |
Leishmania braziliensis | LbrM.21.1240 | epsilon tubulin, putative |
Leishmania donovani | LdBPK_211250.1 | epsilon tubulin, putative |
Leishmania infantum | LinJ.21.1250 | epsilon tubulin, putative |
Leishmania major | LmjF.21.1010 | epsilon tubulin, putative |
Leishmania mexicana | LmxM.21.1010 | epsilon tubulin, putative |
Mus musculus | ENSMUSG00000019845 | epsilon-tubulin 1 |
Neospora caninum | NCLIV_007070 | tubulin epsilon chain, putative |
Plasmodium berghei | PBANKA_1300500 | tubulin epsilon chain, putative |
Plasmodium falciparum | PF3D7_1475700 | tubulin epsilon chain, putative |
Plasmodium knowlesi | PKNH_1246000 | tubulin epsilon chain, putative |
Plasmodium vivax | PVX_118660 | tubulin epsilon chain, putative |
Plasmodium yoelii | PY05777 | tubulin beta chain |
Schistosoma japonicum | Sjp_0009290 | ko:K10391 tubulin epsilon, putative |
Schistosoma mansoni | Smp_028360 | tubulin subunit epsilon |
Schmidtea mediterranea | mk4.013167.01 | Tubulin epsilon chain |
Schmidtea mediterranea | mk4.013167.02 | Tubulin epsilon chain, putative |
Schmidtea mediterranea | mk4.016956.01 | Tubulin epsilon chain, putative |
Schmidtea mediterranea | mk4.023212.00 | Tubulin epsilon chain, putative |
Schmidtea mediterranea | mk4.016956.00 | |
Trypanosoma brucei gambiense | Tbg972.10.1240 | epsilon tubulin |
Trypanosoma brucei | Tb927.10.1140 | epsilon tubulin |
Trypanosoma brucei | Tb11.0530 | epsilon tubulin |
Trypanosoma congolense | TcIL3000_10_940 | epsilon tubulin |
Trypanosoma cruzi | TcCLB.509967.160 | epsilon tubulin, putative |
Trypanosoma cruzi | TcCLB.509695.120 | epsilon tubulin, putative |
Toxoplasma gondii | TGME49_275970 | tubulin, putative |
Toxoplasma gondii | TGME49_275870 | tubulin/FtsZ family, GTPase domain-containing protein |
Trichomonas vaginalis | TVAG_065740 | tubulin gamma chain, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.1140 this record | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.1140 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.1140 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.1140 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1300500 | Plasmodium berghei | Dispensable | plasmo |
TGME49_275870 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_275970 | Toxoplasma gondii | Probably non-essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | increased (PATO:0000470) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.5
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Leishmania major | epsilon tubulin, putative | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Leishmania major | beta tubulin | 443 aa | 30.0% | 443 aa | Compounds | References |
Leishmania major | beta tubulin | 443 aa | 30.0% | 443 aa | Compounds | References |
Ovis aries | Tubulin alpha 4a | 448 aa | 26.3% | 479 aa | Compounds | References |
Leishmania major | alpha tubulin | 451 aa | 26.3% | 475 aa | Compounds | References |
Trypanosoma brucei | alpha tubulin | 451 aa | 26.7% | 476 aa | Compounds | References |
Leishmania major | alpha tubulin | 451 aa | 26.3% | 475 aa | Compounds | References |
Sus scrofa | Tubulin | 445 aa | 29.6% | 446 aa | Compounds | References |
Trypanosoma brucei | tubulin gamma chain | 447 aa | 28.5% | 491 aa | Compounds | References |
Leishmania major | alpha tubulin | 451 aa | 26.3% | 475 aa | Compounds | References |
Leishmania major | gamma-tubulin | 447 aa | 28.3% | 491 aa | Compounds | References |
Trypanosoma brucei | alpha tubulin | 451 aa | 26.7% | 476 aa | Compounds | References |
Leishmania major | alpha tubulin | 451 aa | 26.3% | 475 aa | Compounds | References |
Plasmodium falciparum | tubulin beta chain | 445 aa | 29.6% | 446 aa | Compounds | References |
Leishmania major | alpha tubulin | 451 aa | 26.3% | 475 aa | Compounds | References |
Leishmania major | alpha tubulin | 451 aa | 26.3% | 475 aa | Compounds | References |
Sus scrofa | Tubulin alpha chain | 451 aa | 25.7% | 478 aa | Compounds | References |
Leishmania major | beta tubulin | 443 aa | 30.0% | 443 aa | Compounds | References |
Leishmania major | alpha tubulin | 451 aa | 26.3% | 475 aa | Compounds | References |
Trypanosoma brucei | alpha tubulin | 451 aa | 26.7% | 476 aa | Compounds | References |
Leishmania major | alpha tubulin | 451 aa | 26.3% | 475 aa | Compounds | References |
Leishmania major | alpha tubulin | 451 aa | 26.3% | 475 aa | Compounds | References |
Leishmania major | beta tubulin | 443 aa | 30.0% | 443 aa | Compounds | References |
Leishmania major | beta tubulin | 443 aa | 30.0% | 443 aa | Compounds | References |
Leishmania major | beta tubulin | 443 aa | 30.0% | 443 aa | Compounds | References |
Leishmania major | beta tubulin | 443 aa | 30.0% | 443 aa | Compounds | References |
Leishmania major | beta tubulin | 443 aa | 30.0% | 443 aa | Compounds | References |
Bos taurus | Tubulin beta chain | 445 aa | 29.3% | 443 aa | Compounds | References |
Leishmania major | beta tubulin | 443 aa | 30.0% | 443 aa | Compounds | References |
Leishmania major | beta tubulin | 443 aa | 30.0% | 443 aa | Compounds | References |
Rattus norvegicus | Tubulin alpha-1 chain | 451 aa | 25.9% | 479 aa | Compounds | References |
Plasmodium falciparum | alpha tubulin 1 | 453 aa | 26.8% | 486 aa | Compounds | References |
Bos taurus | Tubulin | 445 aa | 29.3% | 443 aa | Compounds | References |
Leishmania major | alpha tubulin | 451 aa | 26.3% | 475 aa | Compounds | References |
Leishmania major | beta tubulin | 443 aa | 30.0% | 443 aa | Compounds | References |
Leishmania major | beta tubulin | 443 aa | 30.0% | 443 aa | Compounds | References |
Trypanosoma brucei | alpha tubulin | 451 aa | 26.7% | 476 aa | Compounds | References |
Leishmania major | beta tubulin | 443 aa | 30.0% | 443 aa | Compounds | References |
Bos taurus | Tubulin | 85 aa | 23.6% | 110 aa | Compounds | References |
Leishmania major | alpha tubulin | 451 aa | 26.3% | 475 aa | Compounds | References |
Trypanosoma brucei | beta tubulin | 442 aa | 29.4% | 443 aa | Compounds | References |
Leishmania major | alpha tubulin | 451 aa | 26.3% | 475 aa | Compounds | References |
Leishmania major | beta tubulin | 443 aa | 30.0% | 443 aa | Compounds | References |
Leishmania major | beta tubulin | 443 aa | 30.0% | 443 aa | Compounds | References |
1 literature reference was collected for this gene.