Detailed view for Tb927.5.2190

Basic information

TDR Targets ID: 10786
Trypanosoma brucei, META domain/Domain of unknown function (DUF1935), putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.7154 | Length (AA): 446 | MW (Da): 48809 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03724   META domain
PF09149   Domain of unknown function (DUF1935)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_142223)

Species Accession Gene Product
Leishmania braziliensis LbrM.17.1070   META domain containing protein, putative;with=GeneDB:LmjF17.0870
Leishmania donovani LdBPK_170970.1   hypothetical protein, conserved
Leishmania infantum LinJ.17.0970   META domain containing protein, putative;with=GeneDB:LmjF17.0870
Leishmania major LmjF.17.0870   META domain containing protein
Leishmania mexicana LmxM.17.0870   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg972.5.3180   hypothetical protein, conserved
Trypanosoma brucei Tb927.5.2190   META domain/Domain of unknown function (DUF1935), putative
Trypanosoma brucei Tb927.5.2250   META domain/Domain of unknown function (DUF1935), putative
Trypanosoma brucei Tb927.5.2220   META domain/Domain of unknown function (DUF1935), putative
Trypanosoma congolense TcIL3000_0_28530   META domain/Domain of unknown function (DUF1935), putative
Trypanosoma congolense TcIL3000_0_56910   META domain/Domain of unknown function (DUF1935), putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Leishmania major small myristoylated protein-3, putative 115 aa 44.0% 109 aa Compounds References
Leishmania major small myristoylated protein-1 131 aa 42.6% 108 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0293 0.2965 0.2944
0.0615 0.299 0.2979
0.0269 0.3022 0.3022
0.0289 0.2951 0.295
0.0276 0.2792 0.3114
0.0293 0.3022 0.3022
0.0647 0.299 0.2979
0.0264 0.3022 0.3022
0.0249 0.2651 0.2651
0.0314 0.3007 0.2979
0.031 0.2997 0.2918
0.0282 0.2706 0.3096
0.0269 0.3022 0.3022
0.026 0.3022 0.3022
0.0287 0.2746 0.2979
0.0654 0.3006 0.2979
0.0615 0.299 0.2979
0.0289 0.2888 0.2869
0.0264 0.2862 0.2862
0.0293 0.3007 0.2979
0.0619 0.299 0.2979
0.0587 0.299 0.2979
0.0292 0.302 0.302
0.0281 0.2806 0.2895
0.0647 0.2979 0.2979
0.0261 0.2734 0.2979
0.0315 0.3112 0.3097
0.0279 0.2938 0.2938
0.0274 0.269 0.295
0.0288 0.3022 0.3022
0.0312 0.307 0.3068
0.0304727 0.252447 0.250702
0.0275 0.3007 0.2979
0.0283 0.3007 0.2979
0.021 0.316 0.3154
0.0208 0.2991 0.2979
0.0271 0.3007 0.2979
0.0262 0.2951 0.295
0.0615 0.299 0.2979
0.0275 0.3112 0.3096
0.026 0.3098 0.3068
0.0249 0.2651 0.2651
0.0317 0.3007 0.2979
0.0293 0.2979 0.2979
0.0583 0.299 0.2979
0.0276 0.2792 0.3114
0.031 0.3022 0.3022
0.0555 0.299 0.2979
0.0305 0.3022 0.3022
0.0292 0.2872 0.2849
0.0267 0.2938 0.2938
0.0262 0.3022 0.3022
0.0268 0.3022 0.3022
0.0274 0.269 0.295
0.0287 0.2746 0.2979
0.0304 0.3065 0.3091
0.0259 0.3022 0.3022
0.0289 0.2668 0.2956
0.0284 0.2873 0.29
0.0285 0.2635 0.2954
0.0282 0.3112 0.3096
0.0279 0.2915 0.2909
0.0278 0.3022 0.3022
0.0276 0.3007 0.2979
0.0299 0.3007 0.2979
0.0647 0.3006 0.2979
0.0299 0.3038 0.3038
0.0269 0.3022 0.3022
0.0263 0.307 0.3068
0.0294 0.3112 0.3096
0.0273 0.3112 0.3096
0.0261 0.2734 0.2979
0.0263 0.307 0.3068
0.0262 0.2859 0.2745
0.0317 0.3022 0.3022
0.0292 0.302 0.302
0.0294 0.3051 0.3068
0.0285 0.2943 0.295
0.032 0.307 0.3068
0.0278 0.3096 0.3096
0.0276 0.2611 0.2886
0.0263 0.2909 0.2909
0.0323 0.2952 0.295
0.0144 0.2852 0.2745
0.0249 0.2651 0.2651
0.0647 0.3006 0.2979
0.0278 0.3007 0.2979
0.0323 0.2852 0.2784
0.0323 0.2888 0.2888
0.0619 0.299 0.2979
0.0651 0.299 0.2979
0.0278 0.3022 0.3022
0.0619 0.299 0.2979
0.0285 0.2766 0.2989
0.0353 0.2581 0.3103
0.0267 0.2923 0.2891
0.0304 0.3008 0.3068
0.0144 0.2745 0.2745
0.0468 0.299 0.2979
0.0323 0.3111 0.3107
0.0262 0.3027 0.3022
0.0318 0.3117 0.3114
0.0269 0.2915 0.2909
0.0318 0.307 0.3068
0.032 0.3023 0.3022
0.0249 0.2651 0.2651
0.0317 0.3007 0.2979
0.0314 0.307 0.3068
0.0278 0.281 0.2745
0.0311 0.2891 0.2874
0.0265 0.3103 0.3096
0.0651 0.299 0.2979
0.0317 0.3007 0.2979
0.0500157 0.280356 0.27328
0.0275 0.2934 0.2934
0.0323 0.3066 0.3051
0.0304 0.3008 0.3068
0.0292 0.302 0.302
0.0292 0.2941 0.2958
0.0269 0.3112 0.3096
0.0301 0.2936 0.2936
0.0615 0.299 0.2979
0.0314 0.307 0.3068
0.0312 0.307 0.3068
0.0276 0.2792 0.3114
0.0265 0.3103 0.3096
0.0203 0.2672 0.2651
0.032 0.307 0.3068
0.0284 0.2935 0.2935
0.0266 0.2706 0.307
0.0265 0.2968 0.2938
0.0311 0.2891 0.2874
0.0205 0.2872 0.2745
0.0271 0.3027 0.3022
0.0500157 0.280356 0.27328
0.0268 0.2883 0.2816
0.0304 0.2959 0.3068
0.0269 0.3022 0.3022
0.0647 0.299 0.2979
0.0587219 0.280237 0.27328
0.0262 0.3027 0.3022
0.0275 0.3007 0.2979
0.0263 0.2832 0.2697
0.0259 0.2877 0.3114
0.0651 0.299 0.2979
0.0318 0.3117 0.3114
0.0555 0.299 0.2979
0.03 0.3112 0.3097
0.0587 0.299 0.2979
0.0323 0.3111 0.3107
0.0293 0.3007 0.2979
0.0583 0.299 0.2979
0.0288 0.3022 0.3022
0.0267 0.2923 0.2891
0.0587 0.299 0.2979
0.0291 0.2951 0.295
0.0208 0.301 0.301
0.0263 0.3103 0.3096
0.0261 0.2734 0.2979
0.0208 0.301 0.301
0.0146 0.2979 0.2979
0.0273 0.2915 0.2915
0.0323 0.3111 0.3107
0.0318 0.3117 0.3114
0.0279 0.3103 0.3096

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Tb927.5.2190 (Trypanosoma brucei), META domain/Domain of unknown function (DUF1935), putative
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