pI: 6.721 |
Length (AA): 258 |
MW (Da): 29823 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
8 | 194 | 4lmz (A) | 3 | 176 | 25.00 | 0.0024 | 1 | 0.932206 | 0.27 |
10 | 105 | 3s8s (A) | 94 | 185 | 17.00 | 0 | 1 | 0.716493 | -1.3 |
206 | 243 | 5hmo (A) | 813 | 845 | 55.00 | 0.15 | 0.04 | 0.713687 | -1.68 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128231)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G18510 | RNA-binding (RRM/RBD/RNP motifs) family protein |
Babesia bovis | BBOV_III006220 | RNA recognition motif domaining containing protein |
Brugia malayi | Bm1_43460 | Hypothetical RNA-binding protein C08B11.5 in chromosome II |
Candida albicans | CaO19.2261 | similar to U2 snRNA-associated pre-mRNA splicing factor SAP49, S. cerevisiae HSH49 (YOR319W) |
Candida albicans | CaO19.9801 | similar to U2 snRNA-associated pre-mRNA splicing factor SAP49, S. cerevisiae HSH49 (YOR319W) |
Caenorhabditis elegans | CELE_C08B11.5 | Protein SAP-49 |
Cryptosporidium hominis | Chro.60515 | splicing factor |
Cryptosporidium parvum | cgd6_4490 | U2 snRNP. Hsh49p, RRM domain containing protein |
Dictyostelium discoideum | DDB_G0267714 | RNA recognition motif-containing protein RRM |
Drosophila melanogaster | Dmel_CG3780 | Spliceosomal protein on the X |
Echinococcus granulosus | EgrG_000926950 | splicing factor 3b subunit 4 |
Entamoeba histolytica | EHI_012460 | splicing factor 3B subunit 4, putative |
Echinococcus multilocularis | EmuJ_000926950 | splicing factor 3b subunit 4 |
Giardia lamblia | GL50803_25011 | Splicing factor 3B subunit, putative |
Homo sapiens | ENSG00000143368 | splicing factor 3b, subunit 4, 49kDa |
Leishmania braziliensis | LbrM.29.0330 | RNA binding protein, putative |
Leishmania donovani | LdBPK_290400.1 | RNA binding protein, putative |
Leishmania infantum | LinJ.29.0400 | RNA binding protein, putative |
Leishmania major | LmjF.29.0390 | RNA binding protein, putative |
Leishmania mexicana | LmxM.08_29.0390 | RNA binding protein, putative |
Loa Loa (eye worm) | LOAG_01189 | spliceosomal protein on the X |
Mus musculus | ENSMUSG00000068856 | splicing factor 3b, subunit 4 |
Neospora caninum | NCLIV_048140 | splicing factor, putative |
Oryza sativa | 4348798 | Os10g0457000 |
Onchocerca volvulus | OVOC13482 |
|
Plasmodium berghei | PBANKA_1023200 | splicing factor 3B subunit 4, putative |
Plasmodium falciparum | PF3D7_1420000 | splicing factor 3B subunit 4, putative |
Plasmodium knowlesi | PKNH_1338000 | splicing factor 3B subunit 4, putative |
Plasmodium vivax | PVX_085480 | spliceosome-associated protein 49, putative |
Plasmodium yoelii | PY01202 | splicing factor 3b subunit 4 |
Saccharomyces cerevisiae | YOR319W | Hsh49p |
Schistosoma japonicum | Sjp_0031090 | Splicing factor 3B subunit 4, putative |
Schmidtea mediterranea | mk4.037827.00 | Splicing factor 3B subunit 4 |
Schmidtea mediterranea | mk4.007289.00 | Splicing factor 3B subunit 4 |
Trypanosoma brucei gambiense | Tbg972.3.5980 | RNA-binding protein, putative,spliceosome-associated protein, putative |
Trypanosoma brucei | Tb927.3.5280 | spliceosome-associated protein 49, putative |
Trypanosoma congolense | TcIL3000_3_3220 | spliceosome- associated protein, putative |
Trypanosoma cruzi | TcCLB.508409.270 | RNA-binding protein, putative |
Trypanosoma cruzi | TcCLB.510143.80 | RNA-binding protein, putative |
Toxoplasma gondii | TGME49_224580 | RNA recognition motif-containing protein |
Theileria parva | TP02_0374 | spliceosome associated protein, putative |
Trichomonas vaginalis | TVAG_245890 | polyadenylate-binding protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.3.5280 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.5280 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.5280 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.3.5280 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C08B11.5 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_C08B11.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C08B11.5 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C08B11.5 | Caenorhabditis elegans | sterile | wormbase |
YOR319W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1023200 | Plasmodium berghei | Slow | plasmo |
TGME49_224580 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.