pI: 7.1308 |
Length (AA): 263 |
MW (Da): 28980 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 257 | 1n7k (A) | 8 | 235 | 22.00 | 0 | 1 | 1.11 | -1.1 |
3 | 258 | 2a4a (A) | 3 | 258 | 73.00 | 0 | 1 | 1.98 | -2.14 |
3 | 258 | 2a4a (A) | 3 | 258 | 73.00 | 0 | 1 | 1.95928 | -1.85 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, early ring, early schizont, early trophozoite, late ring, late trophozoite, Oocyst, Ring, Female Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, merozoite, sporozoite, late schizont. | Otto TD PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Sporozoite, Male Gametocyte. | Zanghi G Lasonder E |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Ortholog group members (OG5_127821)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_16595 | deoxyribose-phosphate aldolase |
Caenorhabditis elegans | CELE_F09E5.3 | Protein F09E5.3 |
Drosophila melanogaster | Dmel_CG8525 | CG8525 gene product from transcript CG8525-RA |
Escherichia coli | b4381 | 2-deoxyribose-5-phosphate aldolase, NAD(P)-linked |
Echinococcus granulosus | EgrG_000162000 | deoxyribose phosphate aldolase |
Entamoeba histolytica | EHI_121800 | deoxyribose-phosphate aldolase, putative |
Echinococcus multilocularis | EmuJ_000162000 | deoxyribose phosphate aldolase |
Giardia lamblia | GL50803_15127 | Deoxyribose-phosphate aldolase lateral transfer candidate |
Homo sapiens | ENSG00000023697 | deoxyribose-phosphate aldolase (putative) |
Leishmania braziliensis | LbrM.06.1050 | deoxyribose-phosphate aldolase, putative |
Leishmania donovani | LdBPK_061110.1 | deoxyribose-phosphate aldolase, putative |
Leishmania infantum | LinJ.06.1110 | deoxyribose-phosphate aldolase, putative |
Leishmania major | LmjF.06.1070 | deoxyribose-phosphate aldolase, putative |
Leishmania mexicana | LmxM.06.1070 | deoxyribose-phosphate aldolase, putative |
Loa Loa (eye worm) | LOAG_10432 | hypothetical protein |
Mycobacterium leprae | ML2451c | PROBABLE DEOXYRIBOSE-PHOSPHATE ALDOLASE DEOC (PHOSPHODEOXYRIBOALDOLASE) (DEOXYRIBOALDOLASE) |
Mus musculus | ENSMUSG00000030225 | 2-deoxyribose-5-phosphate aldolase homolog (C. elegans) |
Mycobacterium tuberculosis | Rv0478 | Probable deoxyribose-phosphate aldolase DeoC (phosphodeoxyriboaldolase) (deoxyriboaldolase) |
Mycobacterium ulcerans | MUL_4546 | deoxyribose-phosphate aldolase |
Neospora caninum | NCLIV_036120 | deoxyribose-phosphate aldolase, putative |
Plasmodium berghei | PBANKA_0505800 | deoxyribose-phosphate aldolase, putative |
Plasmodium falciparum | PF3D7_1021600 | deoxyribose-phosphate aldolase, putative |
Plasmodium knowlesi | PKNH_0605900 | deoxyribose-phosphate aldolase, putative |
Plasmodium vivax | PVX_001945 | deoxyribose-phosphate aldolase, putative |
Plasmodium yoelii | PY02252 | deoxyribose-phosphate aldolase |
Schistosoma japonicum | Sjp_0039050 | ko:K01619 deoxyribose-phosphate aldolase [EC4.1.2.4], putative |
Schistosoma japonicum | Sjp_0107210 | Putative deoxyribose-phosphate aldolase, putative |
Schistosoma mansoni | Smp_141970 | deoxyribose-phosphate aldolase |
Schmidtea mediterranea | mk4.021160.00 | |
Schmidtea mediterranea | mk4.011344.00 | |
Trypanosoma brucei gambiense | Tbg972.7.6600 | deoxyribose-phosphate aldolase, putative |
Trypanosoma brucei | Tb927.7.5680 | deoxyribose-phosphate aldolase, putative |
Trypanosoma congolense | TcIL3000_7_4670 | deoxyribose-phosphate aldolase, putative |
Trypanosoma cruzi | TcCLB.510303.50 | deoxyribose-phosphate aldolase, putative |
Trypanosoma cruzi | TcCLB.507559.80 | deoxyribose-phosphate aldolase, putative |
Toxoplasma gondii | TGME49_270650 | deoxyribose-phosphate aldolase |
Treponema pallidum | TP0264 | deoxyribose-phosphate aldolase (deoC) |
Trichomonas vaginalis | TVAG_468210 | deoxyribose-phosphate aldolase, putative |
Trichomonas vaginalis | TVAG_393280 | deoxyribose-phosphate aldolase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.5680 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.5680 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.5680 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.7.5680 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b4381 | Escherichia coli | non-essential | goodall |
TGME49_270650 | Toxoplasma gondii | Probably non-essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.2