Detailed view for Tb11.v5.0694

Basic information

TDR Targets ID: 14305
Trypanosoma brucei, glycosyltransferase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 9.6702 | Length (AA): 629 | MW (Da): 70438 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0016757   transferase activity, transferring glycosyl groups  

Metabolic Pathways

N-Glycan biosynthesis (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile Bloodstream Form. Siegel TN
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Procyclic. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_128548)

Species Accession Gene Product
Arabidopsis thaliana AT1G16570   UDP-glycosyltransferase superfamily protein
Brugia malayi Bm1_57590   glycosyl transferase, group 1 family protein
Candida albicans CaO19.4410   Beta-mannosyltransferase
Candida albicans CaO19.11888   Beta-mannosyltransferase
Caenorhabditis elegans CELE_T26A5.4   Protein T26A5.4
Cryptosporidium hominis Chro.70211   glycosyl transferase
Cryptosporidium parvum cgd7_1810   ALG1 like beta-1,4 mannosyltransferase with possible signal peptide
Dictyostelium discoideum DDB_G0286011   hypothetical protein
Drosophila melanogaster Dmel_CG18012   CG18012 gene product from transcript CG18012-RC
Echinococcus granulosus EgrG_000194200   chitobiosyldiphosphodolichol
Entamoeba histolytica EHI_028950   chitobiosyldiphosphodolichol beta-mannosyltransferase, putative
Echinococcus multilocularis EmuJ_000194200   chitobiosyldiphosphodolichol
Homo sapiens 101060670   chitobiosyldiphosphodolichol beta-mannosyltransferase-like
Homo sapiens 56052   ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
Leishmania braziliensis LbrM.18.0960   dolichyl-P-Man:GDP-ManGlcNAc2-PP-dolichyl beta-1,4-mannosyltransferase, putative
Leishmania donovani LdBPK_180900.1   glycosyltransferase, putative
Leishmania infantum LinJ.18.0900   dolichyl-P-Man:GDP-ManGlcNAc2-PP-dolichyl beta-1,4-mannosyltransferase, putative
Leishmania major LmjF.18.0900   dolichyl-P-Man:GDP-ManGlcNAc2-PP-dolichyl beta-1,4-mannosyltransferase, putative
Leishmania mexicana LmxM.18.0900   glycosyltransferase, putative
Loa Loa (eye worm) LOAG_01802   glycosyl transferase
Mus musculus ENSMUSG00000039427   asparagine-linked glycosylation 1 (beta-1,4-mannosyltransferase)
Neospora caninum NCLIV_031100   hypothetical protein
Oryza sativa 4331831   Os03g0180700
Oryza sativa 4341323   Os06g0564800
Saccharomyces cerevisiae YBR110W   chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase
Schistosoma japonicum Sjp_0077160   ko:K03842 beta-1,4-mannosyltransferase, putative
Schistosoma mansoni Smp_005010   chitobiosyldiphosphodolichol alpha-mannosyltransferase
Schmidtea mediterranea mk4.019538.00   Chitobiosyldiphosphodolichol beta-mannosyltransferase
Schmidtea mediterranea mk4.008395.00   Chitobiosyldiphosphodolichol alpha-mannosyltransferase
Schmidtea mediterranea mk4.009979.01   Chitobiosyldiphosphodolichol alpha-mannosyltransferase
Trypanosoma brucei gambiense Tbg972.10.15970   glycosyltransferase, putative
Trypanosoma brucei Tb11.v5.0694   glycosyltransferase, putative
Trypanosoma congolense TcIL3000_10_11300   glycosyltransferase, putative
Trypanosoma cruzi TcCLB.508891.10   dolichyl-P-Man:GDP-ManGlcNAc2-PP-dolichyl beta-1,4-mannosyltransferase, putative
Trypanosoma cruzi TcCLB.504215.20   dolichyl-P-Man:GDP-ManGlcNAc2-PP-dolichyl beta-1,4-mannosyltransferase, putative
Toxoplasma gondii TGME49_230590   chitobiosyldiphosphodolichol beta-mannosyltransferase
Trichomonas vaginalis TVAG_061110   beta1,4 mannosyltransferase, putative

Essentiality

Tb11.v5.0694 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.13210 this record Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.13210 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.13210 this record Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.13210 this record Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T26A5.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_T26A5.4 Caenorhabditis elegans sterile wormbase
YBR110W Saccharomyces cerevisiae inviable yeastgenome
TGME49_230590 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) increased (PATO:0000470) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 3 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

51 literature references were collected for this gene.

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Gene identifier Tb11.v5.0694 (Trypanosoma brucei), glycosyltransferase, putative
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