Detailed view for PF3D7_1346200

Basic information

TDR Targets ID: 145
Plasmodium falciparum, nuclear import protein MOG1, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 5.0422 | Length (AA): 168 | MW (Da): 20385 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04603   Ran-interacting Mog1 protein

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 168 1eq6 (A) 35 218 22.00 0 0.96 1.17 -1.81
7 167 1eq6 (A) 35 217 22.00 0 1 1.28 -1.72
6 168 1eq6 (A) 34 218 21.00 0 0.94 1.19424 -0.87
62 120 3hgf (C) 24 90 39.00 0.4 0 0.42399 0.89

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile Oocyst, Sporozoite. Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 24 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 48 hs, Ring, Female Gametocyte, Male Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 40 hs. Otto TD
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_129574)

Species Accession Gene Product
Arabidopsis thaliana AT1G69680   Mog1/PsbP/DUF1795-like photosystem II reaction center PsbP family protein
Candida albicans CaO19.3446   similar to S. cerevisiae MOG1 (YJR074W) guanine nucleotide release factor for Ran GTPase
Candida albicans CaO19.10950   similar to S. cerevisiae MOG1 (YJR074W) guanine nucleotide release factor for Ran GTPase
Cryptosporidium hominis Chro.10223   HSPC236
Cryptosporidium parvum cgd1_1940   possible RAN guanine nucleotide release factor
Dictyostelium discoideum DDB_G0285871   Mog1 family protein
Echinococcus granulosus EgrG_000849800   ran guanine nucleotide release factor
Echinococcus multilocularis EmuJ_000849800   ran guanine nucleotide release factor
Homo sapiens ENSG00000108961   RAN guanine nucleotide release factor
Leishmania braziliensis LbrM.23.1520   Ran-binding protein, putative
Leishmania donovani LdBPK_231660.1   Ran-binding protein, putative
Leishmania infantum LinJ.23.1660   Ran-binding protein, putative
Leishmania major LmjF.23.1400   Ran-binding protein, putative
Leishmania mexicana LmxM.23.1400   Ran-binding protein, putative
Mus musculus ENSMUSG00000032892   RAN guanine nucleotide release factor
Neospora caninum NCLIV_005440   mog1 protein, putative
Oryza sativa 4336045   Os04g0459600
Plasmodium berghei PBANKA_1359100   nuclear import protein MOG1, putative
Plasmodium falciparum PF3D7_1346200   nuclear import protein MOG1, putative
Plasmodium knowlesi PKNH_1255100   nuclear import protein MOG1, putative
Plasmodium vivax PVX_083210   nuclear import protein MOG1, putative
Plasmodium yoelii PY02511   Homo sapiens HSPC236, putative
Saccharomyces cerevisiae YJR074W   Mog1p
Schistosoma japonicum Sjp_0307600   Ran guanine nucleotide release factor, putative
Schistosoma mansoni Smp_048930   ran-binding protein
Schmidtea mediterranea mk4.012938.00   Ran guanine nucleotide release factor
Schmidtea mediterranea mk4.001713.06   Ran guanine nucleotide release factor
Trypanosoma brucei gambiense Tbg972.8.3130   RNA-binding protein, putative
Trypanosoma brucei Tb927.8.3370   Ran-binding protein, putative
Trypanosoma cruzi TcCLB.509769.63   Ran-binding protein, putative
Toxoplasma gondii TGME49_222040   Ran-interacting Mog1 protein

Essentiality

PF3D7_1346200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.3370 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.3370 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.3370 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.3370 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_1359100 Plasmodium berghei Essential plasmo
TGME49_222040 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

  • Pkno004304AAA;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Pkno004304; Recombinant protein: full-length; Source: P knowlesi; hypothetical protein homolog ; Identifier: PKH_120820

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1346200 (Plasmodium falciparum), nuclear import protein MOG1, putative
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