pI: 8.8078 |
Length (AA): 332 |
MW (Da): 36814 |
Paralog Number:
2
Signal peptide: Y | GPI Anchor: | Predicted trans-membrane segments: 6
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_133432)
Species | Accession | Gene Product |
---|---|---|
Drosophila melanogaster | Dmel_CG11426 | CG11426 gene product from transcript CG11426-RA |
Leishmania braziliensis | LbrM.19.1610 | phosphatidic acid phosphatase protein-like protein |
Leishmania braziliensis | LbrM.18.0480 | phosphatidic acid phosphatase, putative |
Leishmania braziliensis | LbrM.18.0450 | phosphatidic acid phosphatase, putative |
Leishmania donovani | LdBPK_180440.1 | phosphatidic acid phosphatase, putative |
Leishmania donovani | LdBPK_191380.1 | phosphatidic acid phosphatase protein-like protein |
Leishmania infantum | LinJ.18.0440 | phosphatidic acid phosphatase, putative |
Leishmania infantum | LinJ.19.1380 | phosphatidic acid phosphatase protein-like protein |
Leishmania major | LmjF.19.1350 | phosphatidic acid phosphatase protein-like protein |
Leishmania major | LmjF.18.0440 | phosphatidic acid phosphatase, putative |
Leishmania mexicana | LmxM.18.0440 | phosphatidic acid phosphatase, putative |
Leishmania mexicana | LmxM.19.1350 | phosphatidic acid phosphatase protein-like protein |
Trypanosoma brucei gambiense | Tbg972.8.70 | phosphatidic acid phosphatase protein, putative |
Trypanosoma brucei gambiense | Tbg972.10.16180 | phosphatidic acid phosphatase protein, putative |
Trypanosoma brucei | Tb927.8.480 | phosphatidic acid phosphatase protein, putative |
Trypanosoma brucei | Tb927.10.13400 | Phosphatidic acid phostphatase, putative |
Trypanosoma brucei | Tb08.27P2.110 | PAP2 superfamily, putative |
Trypanosoma congolense | TcIL3000_10_11530 | Phosphatidic acid phostphatase, putative |
Trypanosoma congolense | TcIL3000_10_11750 | Phosphatidic acid phostphatase, putative |
Trypanosoma cruzi | TcCLB.511277.359 | phosphatidic acid phosphatase, putative |
Trichomonas vaginalis | TVAG_129900 | phosphatidate phosphatase, putative |
Trichomonas vaginalis | TVAG_111400 | diacylglycerol pyrophosphate phosphatase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.480 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.480 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.480 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.480 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.