pI: 7.1704 |
Length (AA): 314 |
MW (Da): 35222 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
21 | 312 | 4zwn (A) | 1 | 306 | 20.00 | 0 | 1 | 1.20334 | -0.46 |
22 | 312 | 3pe6 (A) | 10 | 293 | 32.00 | 0 | 1 | 1.40915 | -1.26 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127037)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G55180 | alpha/beta-Hydrolases superfamily protein |
Arabidopsis thaliana | AT5G11650 | alpha/beta fold hydrolase family protein |
Arabidopsis thaliana | AT1G18360 | alpha/beta-Hydrolases superfamily protein |
Arabidopsis thaliana | AT2G39400 | alpha/beta-Hydrolases superfamily protein |
Arabidopsis thaliana | AT2G39420 | alpha/beta-Hydrolases superfamily protein |
Arabidopsis thaliana | AT1G73480 | alpha/beta-Hydrolases superfamily protein |
Candida albicans | CaO19.12328 | similar to YJU3 |
Candida albicans | CaO19.4864 | similar to YJU3 |
Dictyostelium discoideum | DDB_G0276087 | hypothetical protein |
Dictyostelium discoideum | DDB_G0269086 | alpha/beta hydrolase fold-1 domain-containing protein |
Escherichia coli | b1410 | putative esterase |
Entamoeba histolytica | EHI_044210 | hydrolase, alpha/beta fold family domain containing protein |
Entamoeba histolytica | EHI_039840 | hydrolase, alpha/beta fold family domain containing protein |
Homo sapiens | ENSG00000074416 | monoglyceride lipase |
Leishmania braziliensis | LbrM.31.1340 | monoglyceride lipase, putative |
Leishmania donovani | LdBPK_311150.1 | monoglyceride lipase, putative |
Leishmania infantum | LinJ.31.1150 | monoglyceride lipase, putative |
Leishmania major | LmjF.31.1140 | monoglyceride lipase, putative |
Leishmania mexicana | LmxM.30.1140 | monoglyceride lipase, putative |
Mycobacterium leprae | ML2603 | POSSIBLE LYSOPHOSPHOLIPASE |
Mus musculus | ENSMUSG00000033174 | monoglyceride lipase |
Mycobacterium tuberculosis | Rv0183 | Possible lysophospholipase |
Mycobacterium ulcerans | MUL_0089 | hypothetical protein |
Mycobacterium ulcerans | MUL_1077 | lysophospholipase |
Oryza sativa | 4351922 | Os12g0262700 |
Oryza sativa | 4333927 | Os03g0719400 |
Oryza sativa | 4346971 | Os09g0394700 |
Oryza sativa | 4327343 | Os01g0199400 |
Plasmodium falciparum | PF3D7_1038900 | esterase, putative |
Plasmodium falciparum | PF3D7_0937200 | lysophospholipase, putative |
Plasmodium falciparum | PF3D7_1476700 | lysophospholipase, putative |
Plasmodium falciparum | PF3D7_1476800 | lysophospholipase, putative |
Plasmodium vivax | PVX_096960 | PST-A protein |
Saccharomyces cerevisiae | YKL094W | Yju3p |
Schmidtea mediterranea | mk4.006872.02 | |
Schmidtea mediterranea | mk4.002673.02 | |
Schmidtea mediterranea | mk4.000137.11 | |
Schmidtea mediterranea | mk4.000137.13 | |
Schmidtea mediterranea | mk4.000137.12 | |
Schmidtea mediterranea | mk4.012753.00 | |
Schmidtea mediterranea | mk4.011109.00 | |
Schmidtea mediterranea | mk4.020061.00 | |
Trypanosoma brucei gambiense | Tbg972.4.4450 | monoglyceride lipase, putative |
Trypanosoma brucei gambiense | Tbg972.8.8340 | monoglyceride lipase, putative |
Trypanosoma brucei | Tb927.4.4360 | monoglyceride lipase, putative |
Trypanosoma brucei | Tb927.8.8020 | monoglyceride lipase, putative |
Trypanosoma congolense | TcIL3000_8_8050 | monoglyceride lipase, putative |
Trypanosoma congolense | TcIL3000_8_8180 | monoglyceride lipase, putative |
Trypanosoma congolense | TcIL3000_4_3730 | monoglyceride lipase, putative |
Trypanosoma cruzi | TcCLB.506489.20 | monoglyceride lipase, putative |
Trichomonas vaginalis | TVAG_165300 | Clan SC, family S33, methylesterase-like serine peptidase |
Trichomonas vaginalis | TVAG_106830 | Clan SC, family S33, methylesterase-like serine peptidase |
Trichomonas vaginalis | TVAG_077180 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_074970 | Clan SC, family S33, methylesterase-like serine peptidase |
Trichomonas vaginalis | TVAG_373610 | Clan SC, family S33, methylesterase-like serine peptidase |
Trichomonas vaginalis | TVAG_032110 | Clan SC, family S33, methylesterase-like serine peptidase |
Trichomonas vaginalis | TVAG_295890 | valacyclovir hydrolase, putative |
Trichomonas vaginalis | TVAG_118450 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu184 | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb927.8.8020 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.8020 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.8020 this record | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.8.8020 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.4.4360 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.4360 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.4360 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.4.4360 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b1410 | Escherichia coli | non-essential | goodall |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Plasmodium falciparum | lysophospholipase, putative | Compounds | References |
Rattus norvegicus | Monoglyceride lipase | Compounds | References |
Mus musculus | monoglyceride lipase | Compounds | References |
Homo sapiens | monoglyceride lipase | Compounds | References |
Plasmodium falciparum | lysophospholipase, putative | Compounds | References |
1 literature reference was collected for this gene.