Detailed view for Tb09.160.5590

Basic information

TDR Targets ID: 16075
Trypanosoma brucei, 60S ribosomal protein L11, putative
Source Database / ID: TriTrypDB / Tb09.160.5590  GeneDB / Tb09.160.5590

pI: 10.9773 | Length (AA): 194 | MW (Da): 22369 | Number of Paralogs: 1

EC number(s): No EC number(s) registered for this gene.

Signal peptide: N | GPI Anchor: N (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

No Pfam domain information for this protein.

Gene Ontology GO:0000315   organellar large ribosomal subunit  
GO:0022625   cytosolic large ribosomal subunit  

Component: (mouse over links to read term descriptions)

GO:0005840   ribosome  
GO:0005622   intracellular  

Function: (mouse over links to read term descriptions)

GO:0003735   structural constituent of ribosome  

Process: (mouse over links to read term descriptions)

GO:0006412   translation  
Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Functional classes

GO:0005198 structural molecule activity
GO:0009987 cellular process

Structural information

Modbase 3D models: no model available for this protein in Modbase.

PDB structures: no structure available for this protein in the PDB.

Expression

No expression information available for this gene.

Antigenicity

Number of putative antigenic epitopes: 9
Cumulative epitope score: 10.0
Normalized epitope score: 5.2
Percentile: 82.5 (this protein belongs to the top 17.5% proteins in the genome of Trypanosoma brucei, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_10156
Number of Paralogs: 1

Ortholog group members from selected species:
Arabidopsis thaliana NP_567563   RPL16B; structural constituent of ribosome ... |   OrthoMCL
Arabidopsis thaliana NP_191429   60S ribosomal protein L11 (RPL11B) ... |   OrthoMCL
Arabidopsis thaliana NP_192040   ribosomal protein L5 family protein ... |   OrthoMCL
Arabidopsis thaliana NP_851137   60S ribosomal protein L11 (RPL11D) ... |   OrthoMCL
Arabidopsis thaliana NP_850376   RPL16A; structural constituent of ribosome ... |   OrthoMCL
Arabidopsis thaliana NP_568649   60S ribosomal protein L11 (RPL11D) ... |   OrthoMCL
Babesia bovis XP_001610475.1   60S ribosomal protein L11 ... |   OrthoMCL
Brugia malayi Bm1_04440   60S ribosomal protein L11, putative... |   OrthoMCL
Caenorhabditis elegans F07D10.1   CE07033 WBGene00004423 locus:rpl-11.2 ribosomal protein stat... |   OrthoMCL
Caenorhabditis elegans T22F3.4   CE13968 WBGene00004422 locus:rpl-11.1 60S ribososmal protein... |   OrthoMCL
Cryptosporidium hominis Chro.60255   ribosomal protein L11 ... |   OrthoMCL
Cryptosporidium muris CMU_007700   60S ribosomal protein L11, putative ... |   OrthoMCL
Cryptosporidium neoformas XP_567416   60s ribosomal protein l11 ... |   OrthoMCL
Cryptosporidium neoformas XP_569508   60s ribosomal protein l7, mitochondrial precursor ... |   OrthoMCL
Cryptosporidium parvum cgd6_2170   60S ribosomal protein L11 ... |   OrthoMCL
Drosophila melanogaster FBpp0085717   |   OrthoMCL
Escherichia coli K12 NP_417767.1   50S ribosomal protein L5 [Escherichia coli K12]... |   OrthoMCL
Giardia intestinalis GL50581_3003   Ribosomal protein L11 ... |   OrthoMCL
Giardia lamblia GLP15_2156   Ribosomal protein L11 ... |   OrthoMCL
Homo sapiens ENSP00000363676   |   OrthoMCL
Leishmania braziliensis LbrM04_V2.0520   |   OrthoMCL
Leishmania braziliensis LbrM22_V2.0030   |   OrthoMCL
Leishmania infantum LinJ04_V3.0460   |   OrthoMCL
Leishmania infantum LinJ22_V3.0004   |   OrthoMCL
Leishmania major LmjF22.0030   60S ribosomal protein L11 (L5, L16)... |   OrthoMCL
Leishmania major LmjF04.0470   60S ribosomal protein L11 (L5, L16)... |   OrthoMCL
Leishmania mexicana LmxM22.0030   |   OrthoMCL
Leishmania mexicana LmxM04.0470   |   OrthoMCL
Mycobacterium leprae strain TN ML1847c   PROBABLE 50S RIBOSOMAL PROTEIN L5 RPLE... |   OrthoMCL
Mus musculus ENSMUSP00000081663   |   OrthoMCL
Mus musculus ENSMUSP00000078670   |   OrthoMCL
Mus musculus ENSMUSP00000078001   |   OrthoMCL
Mycobacterium tuberculosis Rv0716   PROBABLE 50S RIBOSOMAL PROTEIN L5 RPLE... |   OrthoMCL
Neospora caninum NCLIV_053950   |   OrthoMCL
Oryza sativa NP_001054899   Os05g0207300 ... |   OrthoMCL
Oryza sativa NP_001042339   Os01g0205500 ... |   OrthoMCL
Oryza sativa NP_001046386   Os02g0235600 ... |   OrthoMCL
Oryza sativa NP_001048814   Os03g0125000 ... |   OrthoMCL
Oryza sativa NP_001057834   Os06g0550000 ... |   OrthoMCL
Plasmodium berghei PB001409.02.0   60S ribosomal protein L11a, putative ... |   OrthoMCL
Plasmodium chabaudi PCAS_061760   60S ribosomal protein L11a, putative ... |   OrthoMCL
P. falciparum 3D7 PF07_0079   60S ribosomal protein L11a, putative... |   OrthoMCL
Plasmodium knowlesi PKH_031340   60S ribosomal protein L11a, putative ... |   OrthoMCL
Plasmodium vivax PVX_096340   60S ribosomal protein L11, putative... |   OrthoMCL
Plasmodium yoelii PY02461   ribosomal protein L11-like ... |   OrthoMCL
Saccharomyces cerevisiae YGR085C   RPL11B SGDID:S000003317, Chr VII from 648911-648387, reverse... |   OrthoMCL
Saccharomyces cerevisiae YPR102C   RPL11A SGDID:S000006306, Chr XVI from 731746-731222, reverse... |   OrthoMCL
Saccharomyces cerevisiae YDR237W   MRPL7 SGDID:S000002645, Chr IV from 936611-937489, Verified ... |   OrthoMCL
Schistosoma mansoni Smp_050940.2   60S ribosomal protein L11, putative... |   OrthoMCL
Schistosoma mansoni Smp_050940.1   60S ribosomal protein L11, putative... |   OrthoMCL
Trypanosoma brucei gambiense Tbg972.9.4150   |   OrthoMCL
Trypanosoma brucei gambiense Tbg972.9.4140   |   OrthoMCL
Trypanosoma brucei Tb09.160.5580   60S ribosomal protein L11, putative... |   OrthoMCL
Trypanosoma brucei Tb09.160.5590 (this record).   60S ribosomal protein L11, putative... |   OrthoMCL
Trypanosoma congolense TcIL3000.0.18940   |   OrthoMCL
Trypanosoma congolense TcIL3000.0.18950   |   OrthoMCL
Trypanosoma cruzi Tc00.1047053508197.10   60S ribosomal protein L11, putative... |   OrthoMCL
Toxoplasma gondii TGME49_109820   ribosomal protein L11, putative... |   OrthoMCL
Trypanosoma vivax TvY486_0902930   |   OrthoMCL
Wolbachia endosymbiont of Brugia malayi Wbm0329   50S ribosomal protein L5... |   OrthoMCL

Essentiality Tb09.160.5590 has essentiality data
Gene/Ortholog: mtu728 (OG4_10156); Phenotype: essential; Source study: nmpdr
Gene/Ortholog: eco3190 (OG4_10156); Phenotype: undefined; Source study: blattner
Gene/Ortholog: eco3190 (OG4_10156); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco3190 (OG4_10156); Phenotype: essential; Source study: keio
Gene/Ortholog: eco3190 (OG4_10156); Phenotype: essential; Source study: shigen
Gene/Ortholog: cel16038 (OG4_10156); Phenotype: Embryonic Lethal/Arrest; Source study: neb
Gene/Ortholog: cel16038 (OG4_10156); Phenotype: Larval/Adult Lethal/Arrest; Source study: neb
Gene/Ortholog: cel16038 (OG4_10156); Phenotype: Growth Defect; Source study: neb
Gene/Ortholog: cel16038 (OG4_10156); Phenotype: Sterility; Source study: neb
Gene/Ortholog: cel5552 (OG4_10156); Phenotype: Sterility; Source study: neb
Gene/Ortholog: cel5552 (OG4_10156); Phenotype: Larval/Adult Lethal/Arrest; Source study: neb
Gene/Ortholog: cel5552 (OG4_10156); Phenotype: Embryonic Lethal/Arrest; Source study: neb
Gene/Ortholog: cel5552 (OG4_10156); Phenotype: Growth Defect; Source study: neb
Gene/Ortholog: cel16038 (OG4_10156); Phenotype: Embryonic Lethal/Arrest; Source study: wormbase
Gene/Ortholog: cel16038 (OG4_10156); Phenotype: Larval/Adult Lethal/Arrest; Source study: wormbase
Gene/Ortholog: cel16038 (OG4_10156); Phenotype: Sterility; Source study: wormbase
Gene/Ortholog: cel5552 (OG4_10156); Phenotype: Embryonic Lethal/Arrest; Source study: wormbase
Gene/Ortholog: cel5552 (OG4_10156); Phenotype: Larval/Adult Lethal/Arrest; Source study: wormbase
Gene/Ortholog: cel5552 (OG4_10156); Phenotype: Sterility; Source study: wormbase

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability

  • Curated from literature

    No chemical compounds is associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

      • No orthologous druggable targets

    • By sequence similarity to non orthologous druggable targets

      • No additional associated druggable targets
    • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    No literature references are available for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

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