pI: 6.1891 |
Length (AA): 429 |
MW (Da): 46592 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 429 | 4g7f (A) | 1 | 429 | 86.00 | 0 | 1 | 2.0669 | -1.34 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_126698)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G36530 | bifunctional enolase 2/transcriptional activator |
Arabidopsis thaliana | AT1G74030 | enolase 1 |
Arabidopsis thaliana | AT2G29560 | putative phosphoenolpyruvate enolase |
Babesia bovis | BBOV_III007950 | enolase (2-phosphoglycerate dehydratase) |
Brugia malayi | Bm1_24115 | enolase |
Candida albicans | CaO19.8025 | enolase similar to S. cerevisiae ENO1 (YGR254W), gluconeogenesis |
Candida albicans | CaO19.395 | enolase similar to S. cerevisiae ENO1 (YGR254W), gluconeogenesis |
Caenorhabditis elegans | CELE_T21B10.2 | Protein ENOL-1, isoform A |
Cryptosporidium hominis | Chro.50184 | enolase |
Cryptosporidium parvum | cgd5_1960 | enolase (2-phosphoglycerate dehydratase) |
Chlamydia trachomatis | CT_587 | enolase |
Dictyostelium discoideum | DDB_G0268214 | 2-phospho-D-glycerate hydrolase |
Dictyostelium discoideum | DDB_G0283137 | 2-phospho-D-glycerate hydrolase |
Drosophila melanogaster | Dmel_CG17654 | Enolase |
Escherichia coli | b2779 | enolase |
Echinococcus granulosus | EgrG_000514200 | enolase |
Echinococcus granulosus | EgrG_000179700 | enolase |
Entamoeba histolytica | EHI_130700 | enolase, putative |
Echinococcus multilocularis | EmuJ_000514200 | enolase |
Echinococcus multilocularis | EmuJ_000533500 | enolase |
Echinococcus multilocularis | EmuJ_000179700 | enolase |
Giardia lamblia | GL50803_11118 | Enolase |
Homo sapiens | ENSG00000111674 | enolase 2 (gamma, neuronal) |
Homo sapiens | ENSG00000074800 | enolase 1, (alpha) |
Homo sapiens | ENSG00000108515 | enolase 3 (beta, muscle) |
Leishmania braziliensis | LbrM.14.1330 | enolase |
Leishmania braziliensis | LbrM.14.1320 | enolase |
Leishmania donovani | LdBPK_141240.1 | enolase |
Leishmania infantum | LinJ.14.1240 | enolase |
Leishmania major | LmjF.14.1160 | enolase |
Leishmania mexicana | LmxM.14.1160 | enolase |
Loa Loa (eye worm) | LOAG_14155 | enolase |
Loa Loa (eye worm) | LOAG_15787 | enolase |
Loa Loa (eye worm) | LOAG_13911 | enolase |
Loa Loa (eye worm) | LOAG_00912 | enolase |
Mycobacterium leprae | ML0255 | Probable enolase Eno (2-phosphoglycerate dehydratase) (2-phospho-D-glycerate hydro-lyase) |
Mus musculus | ENSMUSG00000060600 | enolase 3, beta muscle |
Mus musculus | ENSMUSG00000059040 | enolase 1B, retrotransposed |
Mus musculus | ENSMUSG00000004267 | enolase 2, gamma neuronal |
Mus musculus | ENSMUSG00000063524 | enolase 1, alpha non-neuron |
Mus musculus | 102642340 | alpha-enolase-like |
Mycobacterium tuberculosis | Rv1023 | Probable enolase Eno |
Mycobacterium ulcerans | MUL_4631 | phosphopyruvate hydratase |
Neospora caninum | NCLIV_037490 | Enolase (EC 4.2.1.11), related |
Neospora caninum | NCLIV_037500 | Enolase (EC 4.2.1.11), related |
Oryza sativa | 4346906 | Os09g0375000 |
Oryza sativa | 4332253 | Os03g0248600 |
Oryza sativa | 4340042 | Os06g0136600 |
Oryza sativa | 4348176 | Os10g0167300 |
Onchocerca volvulus | OVOC10026 | Enolase homolog |
Onchocerca volvulus | OVOC9778 | Enolase homolog |
Plasmodium berghei | PBANKA_1214300 | enolase, putative |
Plasmodium falciparum | PF3D7_1015900 | enolase |
Plasmodium knowlesi | PKNH_0816200 | enolase, putative |
Plasmodium vivax | PVX_095015 | enolase, putative |
Plasmodium yoelii | PY06644 | enolase |
Saccharomyces cerevisiae | YHR174W | phosphopyruvate hydratase ENO2 |
Saccharomyces cerevisiae | YOR393W | phosphopyruvate hydratase ERR1 |
Saccharomyces cerevisiae | YGR254W | phosphopyruvate hydratase ENO1 |
Saccharomyces cerevisiae | YMR323W | phosphopyruvate hydratase ERR3 |
Saccharomyces cerevisiae | YPL281C | phosphopyruvate hydratase ERR2 |
Schistosoma japonicum | Sjp_0209670 | ko:K01689 enolase [EC4.2.1.11], putative |
Schistosoma mansoni | Smp_024110 | phosphopyruvate hydratase |
Schmidtea mediterranea | mk4.001125.11 | |
Schmidtea mediterranea | mk4.001125.12 | Enolase |
Schmidtea mediterranea | mk4.034045.01 | Enolase |
Schmidtea mediterranea | mk4.005541.03 | Enolase |
Schmidtea mediterranea | mk4.002232.01 | Enolase |
Schmidtea mediterranea | mk4.001125.14 | Enolase |
Schmidtea mediterranea | mk4.054382.00 | Enolase |
Trypanosoma brucei gambiense | Tbg972.10.3600 | enolase, putative |
Trypanosoma brucei gambiense | Tbg972.10.3610 | enolase |
Trypanosoma brucei | Tb927.10.2890 | enolase |
Trypanosoma congolense | TcIL3000_10_2500 | enolase, putative |
Trypanosoma cruzi | TcCLB.504105.140 | enolase |
Toxoplasma gondii | TGME49_268860 | enolase 1 |
Toxoplasma gondii | TGME49_268850 | enolase 2 |
Treponema pallidum | TP0817 | phosphopyruvate hydratase |
Theileria parva | TP04_0700 | enolase, putative |
Trichomonas vaginalis | TVAG_263740 | enolase, putative |
Trichomonas vaginalis | TVAG_043500 | enolase, putative |
Trichomonas vaginalis | TVAG_358110 | enolase, putative |
Trichomonas vaginalis | TVAG_464170 | enolase, putative |
Trichomonas vaginalis | TVAG_487600 | enolase, putative |
Trichomonas vaginalis | TVAG_329460 | enolase, putative |
Trichomonas vaginalis | TVAG_282090 | enolase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0119 | phosphopyruvate hydratase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.2890 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.2890 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.2890 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.2890 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b2779 | Escherichia coli | essential | goodall |
CELE_T21B10.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T21B10.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T21B10.2 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_T21B10.2 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T21B10.2 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_1214300 | Plasmodium berghei | Essential | plasmo |
TGME49_268860 | Toxoplasma gondii | Probably essential | sidik |
TGME49_268850 | Toxoplasma gondii | Probably essential | sidik |
TGME49_268860 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_268850 | Toxoplasma gondii | Probably non-essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
growth (GO:0040007) | lethal (sensu genetics) (PATO:0000718) | single cell organism (CARO:0000064) | bloodstream stage (PLO:0040) | inferred from RNAi experiment (ECO:0000019) | Trypanosoma brucei brucei | No drug identifiers listed for this gene. |
Annotator: | ts4@sanger.ac.uk. | Comment: | . | References: | 15955817 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | enolase 2 (gamma, neuronal) | Compounds | References |
Target | Type | Source | Notes |
---|---|---|---|
Tb927.10.2890 | cloned gene | BRENDA | A gene with this EC number or name or sequence has been cloned from Trypanosoma brucei ( 1 ) |
8 literature references were collected for this gene.