pI: 7.9451 |
Length (AA): 699 |
MW (Da): 81092 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 12 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
269 | 713 | 1omw (A) | 44 | 471 | 18.00 | 0 | 1 | 0.62 | 0.43 |
408 | 739 | 1wak (A) | 72 | 653 | 33.00 | 0 | 1 | 0.69 | -0.58 |
6 | 57 | 1llm (C) | 102 | 153 | 2.00 | 0.0000042 | 0 | 0.247892 | -1.79 |
6 | 39 | 2eps (A) | 411 | 445 | 3.00 | 0.0059 | 0 | 0.169141 | -1.36 |
31 | 61 | 2eoz (A) | 8 | 38 | 0.00 | 0.0024 | 0 | 0.270849 | -2.52 |
31 | 63 | 2yrj (A) | 8 | 40 | 0.00 | 0.000016 | 0 | 0.23171 | -2.1 |
276 | 688 | 3kvw (A) | 0 | 463 | 30.00 | 0 | 1 | 0.880844 | 0.34 |
317 | 691 | 4jr7 (A) | 8 | 370 | 27.00 | 0.0000000091 | 1 | 0.549381 | 1.26 |
345 | 689 | 4iir (A) | 668 | 1005 | 54.00 | 0 | 1 | 1.07546 | -0.33 |
640 | 688 | 2i6l (B) | 264 | 317 | 31.00 | 0.0019 | 0.08 | 0.3346 | 0.28 |
653 | 689 | 3nie (A) | 336 | 372 | 43.00 | 0.028 | 0.76 | 0.578433 | -0.45 |
657 | 697 | 4nif (A) | 645 | 685 | 37.00 | 0.001 | 0.72 | 0.540155 | -0.65 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring, Female Gametocyte, Male Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Sporozoite. | Zanghi G |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Ortholog group members (OG5_128795)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G13350 | Protein kinase superfamily protein |
Arabidopsis thaliana | AT3G53640 | protein kinase family protein |
Arabidopsis thaliana | AT3G25840 | serine/threonine-protein kinase PRP4 |
Babesia bovis | BBOV_IV004470 | serine/threonine-protein kinase, putative |
Brugia malayi | Bm1_12230 | Protein kinase domain containing protein |
Caenorhabditis elegans | CELE_F22D6.5 | Protein PRPF-4, isoform B |
Cryptosporidium hominis | Chro.80590 | hypothetical protein |
Cryptosporidium parvum | cgd8_5180 | hypothetical protein |
Dictyostelium discoideum | DDB_G0279703 | DYRK family protein kinase |
Drosophila melanogaster | Dmel_CG7028 | CG7028 gene product from transcript CG7028-RE |
Echinococcus granulosus | EgrG_000670000 | Serine:threonine protein kinase PRP4 |
Entamoeba histolytica | EHI_087600 | protein kinase, putative |
Echinococcus multilocularis | EmuJ_000670000 | Serine:threonine protein kinase PRP4 |
Homo sapiens | ENSG00000112739 | pre-mRNA processing factor 4B |
Loa Loa (eye worm) | LOAG_10875 | CMGC/DYRK/PRP4 protein kinase |
Mus musculus | ENSMUSG00000021413 | PRP4 pre-mRNA processing factor 4 homolog B (yeast) |
Neospora caninum | NCLIV_056510 | Homeodomain interacting protein kinase 3, related |
Oryza sativa | 9269410 | Os03g0710100 |
Oryza sativa | 4352925 | Os12g0640800 |
Plasmodium berghei | PBANKA_0933000 | serine/threonine protein kinase, putative |
Plasmodium falciparum | PF3D7_1114700 | serine/threonine protein kinase, putative |
Plasmodium knowlesi | PKNH_0912200 | protein kinase, putative |
Plasmodium vivax | PVX_091375 | serine/threonine-protein kinase PRP4K, putative |
Plasmodium yoelii | PY02926 | serine/threonine-protein kinase prp4 homolog |
Schistosoma japonicum | Sjp_0066800 | ko:K08827 pre-mRNA-processing factor 4, putative |
Schistosoma mansoni | Smp_068960.2 | serine/threonine protein kinase |
Schistosoma mansoni | Smp_068960.1 | serine/threonine protein kinase |
Schmidtea mediterranea | mk4.000114.17 | Serine/threonine kinase |
Schmidtea mediterranea | mk4.000114.16 | Serine/threonine kinase |
Toxoplasma gondii | TGME49_313180 | cell-cycle-associated protein kinase PRP4, putative |
Theileria parva | TP01_0303 | hypothetical protein |
Trichomonas vaginalis | TVAG_075270 | CMGC family protein kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F22D6.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F22D6.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F22D6.5 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F22D6.5 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_0933000 | Plasmodium berghei | Essential | plasmo |
TGME49_313180 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.5
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | pre-mRNA processing factor 4B | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Mitogen-activated protein kinase 8 | 411 aa | 27.6% | 340 aa | Compounds | References |
Rattus norvegicus | MAP kinase p38 alpha | 360 aa | 26.8% | 328 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 25.9% | 328 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 29.6% | 335 aa | Compounds | References |
Rattus norvegicus | Mitogen-activated protein kinase 1 | 358 aa | 26.5% | 343 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 31.4% | 169 aa | Compounds | References |