Detailed view for Tb927.11.6740

Basic information

TDR Targets ID: 17222
Trypanosoma brucei, pumilio/PUF RNA binding protein 10, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.7774 | Length (AA): 683 | MW (Da): 75168 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005488   binding  
GO:0003723   RNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
106 629 5svd (A) 54 632 17.00 0 1 0.807804 0.61
319 682 3gvo (A) 730 1046 19.00 0 1 0.586543 0.18
338 678 1m8z (A) 830 1162 18.00 0 1 0.668868 -0.38
341 587 3v71 (A) 149 382 28.00 0.0044 1 0.45334 0.48
448 611 3bwt (A) 567 731 21.00 0.049 0.8 0.486817 -0.47
451 683 3k49 (A) 545 781 21.00 0.00027 1 0.625842 -0.45
567 661 3t8y (A) 39 137 29.00 0.27 0.45 0.319792 0.44

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Procyclic. Siegel TN
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_145883)

Species Accession Gene Product
Leishmania braziliensis LbrM.11.0150   pumillio protein 10, putative
Leishmania donovani LdBPK_110470.1   pumilio-repeat, RNA-binding protein, putative
Leishmania infantum LinJ.11.0470   pumillio protein 10, putative
Leishmania major LmjF.11.0470   pumillio protein 10, putative
Leishmania mexicana LmxM.11.0470   pumilio-repeat, RNA-binding protein, putative
Trypanosoma brucei gambiense Tbg972.11.7670   pumilio-repeat, RNA-binding protein, putative
Trypanosoma brucei Tb927.11.6740   pumilio/PUF RNA binding protein 10, putative
Trypanosoma congolense TcIL3000.11.7280   pumilio/PUF RNA binding protein 10, putative
Trypanosoma congolense TcIL3000_0_51110   pumilio/PUF RNA binding protein 10, putative
Trypanosoma cruzi TcCLB.506773.130   pumilio-repeat, RNA-binding protein, putative
Trypanosoma cruzi TcCLB.508799.70   pumilio-repeat, RNA-binding protein, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Tb927.11.6740 (Trypanosoma brucei), pumilio/PUF RNA binding protein 10, putative
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