Detailed view for Tb927.9.7150
Basic information
Trypanosoma brucei, RNA pseudouridylate synthase protein, putative
Source Database / ID: TriTrypDB GeneDB
pI: 7.5799 |
Length (AA): 1254 |
MW (Da): 138100 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
GO:0009982 pseudouridine synthase activity
GO:0003723 RNA binding
GO:0009451 RNA modification
GO:0006396 RNA processing
GO:0001522 pseudouridine synthesis
Metabolic Pathways
Structural information
Modbase 3D models:
PDB Structures:
Expression
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Mid 40-60% percentile | Procyclic, Bloodstream Form. | Siegel TN |
-
Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.
Orthologs
Ortholog group members (OG5_147611)
| Species | Accession | Gene Product |
|---|---|---|
| Leishmania braziliensis | LbrM.04.0290 | RNA pseudouridylate synthase-like protein |
| Leishmania donovani | LdBPK_040240.1 | RNA pseudouridylate synthase-like protein |
| Leishmania infantum | LinJ.04.0240 | RNA pseudouridylate synthase-like protein |
| Leishmania major | LmjF.04.0250 | RNA pseudouridylate synthase-like protein |
| Leishmania mexicana | LmxM.04.0250 | RNA pseudouridylate synthase-like protein |
| Trypanosoma brucei gambiense | Tbg972.9.3830 | RNA pseudouridylate synthase protein, putative |
| Trypanosoma brucei | Tb927.9.7150 | RNA pseudouridylate synthase protein, putative |
| Trypanosoma cruzi | TcCLB.506625.249 | RNA pseudouridylate synthase protein, putative |
| Trypanosoma cruzi | TcCLB.510221.10 | RNA pseudouridylate synthase, putative |
Essentiality
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Known modulators for this target
Predicted associations
By orthology with druggable targets
By sequence similarity to non orthologous druggable targets
Obtained from network model
Assayability
Assay information
Reagent availability
Bibliographic References
1 literature reference was collected for this gene.