pI: 7.0741 |
Length (AA): 1100 |
MW (Da): 119556 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 10
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
37 | 1037 | 3wgu (A) | 26 | 1004 | 18.00 | 0.000000000019 | 1 | 0.993 | 0.86 |
74 | 1036 | 2zxe (A) | 62 | 1010 | 24.00 | 0 | 1 | 1.00325 | 0.71 |
748 | 789 | 3fvv (A) | 173 | 213 | 24.00 | 0 | 0.09 | 0.252982 | -0.11 |
750 | 810 | 3a1c (A) | 606 | 666 | 43.00 | 0 | 0.29 | 0.460255 | 0.33 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_152262)
Species | Accession | Gene Product |
---|---|---|
Leishmania braziliensis | LbrM.33.1200 | calcium-transporting ATPase, putative |
Leishmania donovani | LdBPK_331060.1 | calcium-transporting ATPase, putative |
Leishmania infantum | LinJ.33.1060 | calcium-transporting ATPase, putative |
Leishmania major | LmjF.33.1010 | calcium-transporting ATPase, putative |
Leishmania mexicana | LmxM.32.1010 | calcium-transporting ATPase, putative |
Trypanosoma brucei gambiense | Tbg972.10.13990 | calcium-transporting ATPase, putative |
Trypanosoma brucei | Tb11.v5.0712 | calcium-transporting ATPase, putative |
Trypanosoma brucei | Tb927.10.11620 | calcium-transporting ATPase, putative |
Trypanosoma cruzi | TcCLB.509647.150 | calcium-transporting ATPase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.11620 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.11620 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.11620 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.11620 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.5
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | 1043 aa | 27.2% | 874 aa | Compounds | References |
Rattus norvegicus | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 994 aa | 26.6% | 879 aa | Compounds | References |
Trypanosoma cruzi | P-type H+-ATPase, putative | 645 aa | 24.0% | 637 aa | Compounds | References |
Oryctolagus cuniculus | Sarcoplasmic/endoplasmic reticulum calcium ATP-ase | 1001 aa | 26.8% | 883 aa | Compounds | References |
4 literature references were collected for this gene.