Detailed view for PF3D7_1356800

Basic information

TDR Targets ID: 193
Plasmodium falciparum, serine/threonine protein kinase, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.3139 | Length (AA): 4044 | MW (Da): 475716 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005952   cAMP-dependent protein kinase complex  
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 24 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1117 1617 1omw (A) 34 560 20.00 0 1 0.28 0.44
1151 1745 1omw (A) 88 667 18.00 0 1 -0.12 0.84
1274 1528 1mq4 (A) 131 383 34.00 0 1 0.59 -1.37
5 524 1s0f (A) 740 1256 29.00 0.58 0.05 -0.142114 1.8
1116 1528 5dzc (A) 367 791 25.00 0 1 0.306027 0.67
1125 1559 4wnk (A) 40 493 19.00 0.000000017 1 0.112267 0.36
1163 1656 3uzt (A) 74 618 22.00 0 1 0.191056 1.22
1234 1551 1opk (A) 205 531 20.00 0 1 0.237535 0.32
1240 1476 4oh4 (A) 864 1087 35.00 0.0023 0.9 0.0859053 0.97
1276 1532 4b6l (A) 62 318 26.00 0 1 0.448451 -0.54
1276 1532 2rku (A) 53 309 27.00 0 1 0.446451 -0.42
1280 1753 3q5i (A) 51 503 29.00 0.000000014 1 0.172511 0.59
1331 1475 2xk7 (A) 62 216 41.00 0.02 0.83 0.127156 0.96
1521 2437 5czz (A) 99 1040 22.00 0.21 0.98 0.0820557 1.67
3094 4043 5czz (A) 55 1024 22.00 0.049 0.98 0.157816 1.36
3290 3610 4o87 (A) 14 312 28.00 0.17 0.32 0.0196769 0.86
3387 3768 4h5y (A) 72 456 22.00 0.72 0.55 0.138361 0.42
5 524 1s0f (A) 740 1256 29.00 0.49 0.14 -0.120283 1.69
46 748 3s5m (A) 256 1010 21.00 0.21 0.96 0.0349808 1.31
1107 1563 4tnd (A) 26 478 18.00 0.0000000072 1 0.153735 0.2
1178 1683 3uzs (A) 92 620 17.00 0.000000068 1 0.00485459 1.51
1255 1524 1jpa (A) 606 886 23.00 0 0.96 0.244882 0.29
1521 2436 5czz (A) 99 1040 22.00 0.18 1 0.0806644 1.72
3443 3604 4tql (A) 24 189 27.00 0.45 0.09 0.405169 -1.75

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile late schizont, Female Gametocyte. PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile gametocyte, merozoite. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Male Gametocyte. Otto TD Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, Oocyst. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Ring, Sporozoite. Zanghi G
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_160431)

Species Accession Gene Product
Cryptosporidium hominis Chro.60086   OSK4
Plasmodium berghei PBANKA_1133100   serine/threonine protein kinase, putative
Plasmodium falciparum PF3D7_1356800   serine/threonine protein kinase, putative
Plasmodium knowlesi PKNH_1114700   serine/threonine protein kinase, putative
Plasmodium vivax PVX_114820   protein kinase domain containing protein
Plasmodium yoelii PY02340   chloroquine resistance marker protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Patiria pectinifera Cdc2 300 aa 27.5% 291 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 29.4% 265 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 24.4% 299 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0003 0.5 0.5
0.0007 0.5 0.5
0.0092 1 0.5
0.0039 0.5 0.5
0.0063 0.7244 0.7244
0.0061 0.6883 1
0.0032 0.5 0.5
0.0069 0.3067 1
0.0012 0.5 0.5
0.0027 1 0.5
0.0091 1 0.5
0.0026 0.5 0.5
0.0008 0.5 0.5
0.0036 0.5 0.5
0.0022 0.5 0.5
0.0039 0.5 0.5
0.0042 0.5 0.5
0.0067 0.5 0.5
0.0059 1 1
0.0004 0.5 0.5
0.0081 0.5 0.5
0.0066 0.3101 0
0.0081 1 0.5
0.0033 1 1
0.0039 0.9485 0.5
0.0016 0.5 0.5
0.0088 0.4477 0.5
0.0056 1 0.5
0.0063 1 1
0.0098 0.3242 0.2614
0.0012 0.5 0.5
0.0033 0.5 0.5
0.0007 0.5 0.5
0.0059 1 1
0.0064 0.3377 0
0.0012 0.5 0.5
0.0007 0.5 0.5
0.0016 0.5 0.5
0.0032 0.5 0.5
0.0059 1 1
0.0018 0.5 0.5
0.0037 1 0.5
0.0093 0.8828 0
0.0029 0.5 0.5
0.0062 0.6935 0
0.0011 1 0.5
0.0023 0.5 0.5

Assayability

Assay information

  • Assay for Protein Kinase C (2.7.1.37 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

No reagent availability information for this target.

Bibliographic References

180 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1356800 (Plasmodium falciparum), serine/threonine protein kinase, putative
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