Detailed view for Tb11.v5.1057

Basic information

TDR Targets ID: 19788
Trypanosoma brucei, protein kinase, putative

Source Database / ID: TriTrypDB / Tb11.v5.1057  GeneDB / Tb11.v5.1057

pI: 5.9985 | Length (AA): 413 | MW (Da): 47390 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: ND

Pfam domains

PF00069   Protein kinase domain
PF12330   Haspin like kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Network

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models: 3

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 350 4qny (A) 4 350 77.00 0 1 1.77197 -1.52
16 59 4mvf (A) 66 109 36.00 0 0.85 0.497238 0
18 409 5dvr (A) 47 498 27.00 0 1 1.08525 0.34

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126781)
Species Accession Gene Product
Arabidopsis thaliana AT1G01560   mitogen-activated protein kinase 11
Arabidopsis thaliana AT2G18170   mitogen-activated protein kinase 7
Arabidopsis thaliana AT3G45640   mitogen-activated protein kinase 3
Arabidopsis thaliana AT4G01370   mitogen-activated protein kinase 4
Arabidopsis thaliana AT3G59790   mitogen-activated protein kinase 10
Arabidopsis thaliana AT4G11330   mitogen-activated protein kinase 5
Arabidopsis thaliana AT4G36450   mitogen-activated protein kinase 14
Arabidopsis thaliana AT1G10210   mitogen-activated protein kinase 1
Arabidopsis thaliana AT1G59580   mitogen-activated protein kinase 2
Arabidopsis thaliana AT1G07880   mitogen-activated protein kinase 13
Arabidopsis thaliana AT2G43790   MAP kinase 6
Brugia malayi Bm1_46485   MAP kinase sur-1
Candida albicans CaO19.10404   MAP kinase-like orf
Candida albicans CaO19.2886   MAP kinase-like orf
Candida albicans CaO19.8091   Serine/threonine protein kinase of MAP kinase family
Candida albicans CaO19.7523   MAP kinase implicated in PKC1-controlled signalling pathway
Candida albicans CaO19.460   Serine/threonine protein kinase of MAP kinase family
Caenorhabditis elegans CELE_F43C1.2   Protein MPK-1, isoform A
Cryptosporidium hominis Chro.30343   MAPK
Cryptosporidium parvum cgd3_3030   MAPK, putative
Dictyostelium discoideum DDB_G0286353   ERK subfamily protein kinase
Drosophila melanogaster Dmel_CG12559   rolled
Echinococcus granulosus EgrG_000803700   mitogen activated protein kinase 3
Echinococcus granulosus EgrG_000891000   mitogen activated protein kinase
Echinococcus multilocularis EmuJ_000891000   mitogen activated protein kinase
Echinococcus multilocularis EmuJ_000803700   mitogen activated protein kinase 3
Giardia lamblia GL50803_17563   Kinase, CMGC MAPK
Homo sapiens ENSG00000102882   mitogen-activated protein kinase 3
Homo sapiens ENSG00000166484   mitogen-activated protein kinase 7
Homo sapiens ENSG00000100030   mitogen-activated protein kinase 1
Leishmania braziliensis LbrM.33.1650   mitogen activated protein kinase, putative,map kinase, putative
Leishmania braziliensis LbrM.19.1710   mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase
Leishmania donovani LdBPK_331470.1   mitogen activated protein kinase, putative
Leishmania donovani LdBPK_191480.1   mitogen-activated protein kinase 4
Leishmania infantum LinJ.19.1480   mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440
Leishmania infantum LinJ.33.1470   mitogen activated protein kinase, putative,map kinase, putative
Leishmania major LmjF.19.1440   mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440
Leishmania major LmjF.33.1380   mitogen activated protein kinase, putative,map kinase, putative
Leishmania mexicana LmxM.19.1440   mitogen-activated protein kinase
Leishmania mexicana LmxM.32.1380   mitogen activated protein kinase, putative,map kinase, putative
Loa Loa (eye worm) LOAG_08585   CMGC/MAPK/ERK1 protein kinase
Mus musculus ENSMUSG00000063358   mitogen-activated protein kinase 1
Mus musculus ENSMUSG00000063065   mitogen-activated protein kinase 3
Mus musculus ENSMUSG00000001034   mitogen-activated protein kinase 7
Oryza sativa 4340170   Os06g0154500
Oryza sativa 4344698   Os08g0157000
Oryza sativa 4349225   Os10g0533600
Oryza sativa 4332475   Os03g0285800
Oryza sativa 4341956   Os06g0699400
Oryza sativa 4328297   Os02g0148100
Saccharomyces cerevisiae YGR040W   mitogen-activated serine/threonine-protein kinase KSS1
Saccharomyces cerevisiae YBL016W   mitogen-activated serine/threonine-protein kinase FUS3
Saccharomyces cerevisiae YHR030C   mitogen-activated serine/threonine-protein kinase SLT2
Schistosoma japonicum Sjp_0132780   Mitogen-activated protein kinase 3, putative
Schistosoma japonicum Sjp_0044730   ko:K04371 extracellular signal-regulated kinase 1/2, putative
Schistosoma japonicum Sjp_0035520   Mitogen-activated protein kinase 3, putative
Schistosoma mansoni Smp_142050   serine/threonine protein kinase
Schmidtea mediterranea mk4.000508.08   Mitogen-activated protein kinase ERK-A
Schmidtea mediterranea mk4.002179.01  
Schmidtea mediterranea mk4.005156.02   Mitogen-activated protein kinase ERK-A
Schmidtea mediterranea mk4.017998.00   Mitogen-activated protein kinase mpk-1
Schmidtea mediterranea mk4.016766.00   Mitogen-activated protein kinase ERK-A
Schmidtea mediterranea mk4.001937.03   Mitogen-activated protein kinase ERK-A
Schmidtea mediterranea mk4.009672.00   Mitogen-activated protein kinase ERK-A
Schmidtea mediterranea mk4.000030.09  
Schmidtea mediterranea mk4.015572.01  
Trypanosoma brucei gambiense Tbg972.10.19640   mitogen-activated protein kinase, putative
Trypanosoma brucei gambiense Tbg972.10.14510   protein kinase, putative,tyrosine protein kinase, putative
Trypanosoma brucei Tb927.10.16030   mitogen activated protein kinase 4, putative
Trypanosoma brucei Tb11.v5.1057 this record   protein kinase, putative
Trypanosoma congolense TcIL3000_10_10240   tyrosine protein kinase, putative
Trypanosoma cruzi TcCLB.511299.70   mitogen activated protein kinase 2, putative
Trypanosoma cruzi TcCLB.511837.70   mitogen-activated protein kinase 11, putative
Trypanosoma cruzi TcCLB.506483.69   mitogen activated protein kinase 4, putative
Trypanosoma cruzi TcCLB.510123.20   mitogen-activated protein kinase 11, putative
Toxoplasma gondii TGME49_312570   CMGC kinase, MAPK family (ERK) MAPK-1
Trichomonas vaginalis TVAG_008800   CMGC family protein kinase
Trichomonas vaginalis TVAG_307130   CMGC family protein kinase
Trichomonas vaginalis TVAG_258130   CMGC family protein kinase
Trichomonas vaginalis TVAG_338030   CMGC family protein kinase

Essentiality

Tb11.v5.1057 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.12040 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.12040 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.12040 this record Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.12040 this record Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.16030 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.16030 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.16030 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.16030 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F43C1.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_F43C1.2 Caenorhabditis elegans larval arrest wormbase
CELE_F43C1.2 Caenorhabditis elegans larval lethal wormbase
CELE_F43C1.2 Caenorhabditis elegans sterile wormbase
TGME49_312570 Toxoplasma gondii Probably essential sidik

Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in procyclic forms . References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.9

Curated from literature

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens mitogen-activated protein kinase 1 Compounds References
Mus musculus mitogen-activated protein kinase 1 Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 Compounds References
Homo sapiens mitogen-activated protein kinase 3 Compounds References
Mus musculus mitogen-activated protein kinase 3 Compounds References
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Compounds References
Homo sapiens mitogen-activated protein kinase 7 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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User comments

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Gene identifier Tb11.v5.1057 (Trypanosoma brucei), protein kinase, putative
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TDR Targets Development Release v6, Revision: 1335 (10.Aug.2018)
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