pI: 7.6919 |
Length (AA): 192 |
MW (Da): 21586 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 192 | 1x9g (A) | 1 | 192 | 96.00 | 0 | 1 | 2.2 | -2.12 |
1 | 192 | 1x9g (A) | 1 | 192 | 96.00 | 0 | 1 | 2.2354 | -1.84 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | amastigotes, metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_129244)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_51490 | isochorismatase family protein |
Caenorhabditis elegans | CELE_F35G2.2 | Protein F35G2.2 |
Dictyostelium discoideum | DDB_G0284901 | hypothetical protein |
Dictyostelium discoideum | DDB_G0285041 | hypothetical protein |
Drosophila melanogaster | Dmel_CG11333 | CG11333 gene product from transcript CG11333-RA |
Drosophila melanogaster | Dmel_CG3663 | CG3663 gene product from transcript CG3663-RA |
Echinococcus granulosus | EgrG_001024400 | isochorismatase domain containing protein 2 |
Echinococcus multilocularis | EmuJ_001024400 | isochorismatase domain containing protein 2 |
Homo sapiens | ENSG00000066583 | isochorismatase domain containing 1 |
Homo sapiens | ENSG00000063241 | isochorismatase domain containing 2 |
Leishmania braziliensis | LbrM.12.0080 | ribonuclease mar1 |
Leishmania donovani | LdBPK_120060.1 | hypothetical protein, conserved |
Leishmania infantum | LinJ.12.0007 | MAR1 ribonuclease, putative |
Leishmania major | LmjF.12.0060 | ribonuclease mar1 |
Leishmania mexicana | LmxM.12.0060 | ribonuclease mar1 |
Loa Loa (eye worm) | LOAG_15045 | isochorismatase |
Loa Loa (eye worm) | LOAG_00074 | hypothetical protein |
Mus musculus | ENSMUSG00000086784 | isochorismatase domain containing 2a |
Mus musculus | ENSMUSG00000024601 | isochorismatase domain containing 1 |
Mus musculus | ENSMUSG00000052605 | isochorismatase domain containing 2b |
Onchocerca volvulus | OVOC6895 |
|
Schistosoma japonicum | Sjp_0013760 | Isochorismatase domain-containing protein 1, putative |
Schistosoma mansoni | Smp_000630 | isochorismatase family protein |
Schmidtea mediterranea | mk4.007275.00 | |
Schmidtea mediterranea | mk4.007802.00 | |
Trypanosoma cruzi | TcCLB.509553.30 | ribonuclease mar1, putative |
Trypanosoma cruzi | TcCLB.509553.40 | ribonuclease mar1, putative |
Trypanosoma cruzi | TcCLB.505945.20 | ribonuclease mar1, putative |
Trypanosoma cruzi | TcCLB.505945.30 | ribonuclease mar1, putative |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Type | Source | Notes |
---|---|---|
soluble recombinant protein | Structural Genomics for Pathogenic Protozoa (SGPP) | Lmaj001686; Recombinant protein: full-length; Source: L major; ribonuclease mar1 ; |