pI: 7.7606 |
Length (AA): 511 |
MW (Da): 55548 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
109 | 510 | 1sc6 (A) | 7 | 409 | 51.00 | 0 | 1 | 1.34 | -1.39 |
113 | 419 | 1wwk (A) | 1 | 304 | 42.00 | 0 | 1 | 1.23 | -1.52 |
114 | 511 | 1ygy (A) | 6 | 527 | 31.00 | 0 | 1 | 0.76 | -0.78 |
67 | 416 | 3wr5 (A) | 4 | 356 | 25.00 | 0 | 1 | 0.949831 | 0.22 |
107 | 510 | 1yba (A) | 5 | 409 | 51.00 | 0 | 1 | 1.44521 | -0.68 |
213 | 393 | 4z0p (A) | 100 | 282 | 23.00 | 0.04 | 1 | 0.711807 | -0.91 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | amastigotes. | Fernandes MC |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_127006)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G17745 | D-3-phosphoglycerate dehydrogenase |
Arabidopsis thaliana | AT4G34200 | D-3-phosphoglycerate dehydrogenase |
Arabidopsis thaliana | AT3G19480 | D-3-phosphoglycerate dehydrogenase |
Brugia malayi | Bm1_57055 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain containing protein |
Candida albicans | CaO19.12728 | similar to S. cerevisiae SER3 (YER081W) 3-phosphoglycerate dehydrogenase |
Candida albicans | CaO19.5263 | similar to S. cerevisiae SER3 (YER081W) 3-phosphoglycerate dehydrogenase |
Caenorhabditis elegans | CELE_C31C9.2 | Protein C31C9.2 |
Dictyostelium discoideum | DDB_G0281071 | 3-phosphoglycerate dehydrogenase |
Drosophila melanogaster | Dmel_CG6287 | CG6287 gene product from transcript CG6287-RA |
Escherichia coli | b2913 | D-3-phosphoglycerate dehydrogenase |
Entamoeba histolytica | EHI_060860 | D-3-phosphoglycerate dehydrogenase, putative |
Homo sapiens | ENSG00000092621 | phosphoglycerate dehydrogenase |
Leishmania braziliensis | LbrM.03.0050 | D-3-phosphoglycerate dehydrogenase-like protein |
Leishmania donovani | LdBPK_030030.1 | D-3-phosphoglycerate dehydrogenase-like protein |
Leishmania infantum | LinJ.03.0030 | D-3-phosphoglycerate dehydrogenase-like protein |
Leishmania major | LmjF.03.0030 | D-3-phosphoglycerate dehydrogenase-like protein |
Leishmania mexicana | LmxM.03.0030 | D-3-phosphoglycerate dehydrogenase-like protein |
Loa Loa (eye worm) | LOAG_05547 | hypothetical protein |
Mycobacterium leprae | ML1692c | PROBABLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA1 (PGDH) |
Mus musculus | ENSMUSG00000053398 | 3-phosphoglycerate dehydrogenase |
Mycobacterium tuberculosis | Rv2996c | Probable D-3-phosphoglycerate dehydrogenase SerA1 (PGDH) |
Mycobacterium ulcerans | MUL_1952 | D-3-phosphoglycerate dehydrogenase |
Neospora caninum | NCLIV_016450 | hypothetical protein |
Oryza sativa | 4337230 | Os04g0650800 |
Oryza sativa | 4341713 | Os06g0655100 |
Oryza sativa | 4345710 | Os08g0447000 |
Onchocerca volvulus | OVOC5897 |
|
Saccharomyces cerevisiae | YIL074C | phosphoglycerate dehydrogenase SER33 |
Saccharomyces cerevisiae | YER081W | phosphoglycerate dehydrogenase SER3 |
Schistosoma japonicum | Sjp_0016670 | ko:K00058 D-3-phosphoglycerate dehydrogenase [EC1.1.1.95], putative |
Schmidtea mediterranea | mk4.065236.01 | D-3-phosphoglycerate dehydrogenase |
Schmidtea mediterranea | mk4.000146.05 | D-3-phosphoglycerate dehydrogenase |
Toxoplasma gondii | TGME49_239820 | D-3-phosphoglycerate dehydrogenase |
Trichomonas vaginalis | TVAG_432360 | 2-hydroxyacid dehydrogenase, putative |
Trichomonas vaginalis | TVAG_462360 | 2-hydroxyacid dehydrogenase, putative |
Trichomonas vaginalis | TVAG_154750 | D-3-phosphoglycerate dehydrogenase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b2913 | Escherichia coli | non-essential | goodall |
CELE_C31C9.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C31C9.2 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_239820 | Toxoplasma gondii | Probably non-essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.2