pI: 5.5604 |
Length (AA): 708 |
MW (Da): 76800 |
Paralog Number:
9
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 11
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
387 | 521 | 1mgy (A) | 13 | 153 | 16.00 | 0.0000033 | 0 | 0.39 | -1.03 |
500 | 583 | 3uxy (A) | 108 | 190 | 29.00 | 0.18 | 0.02 | 0.171444 | 1.65 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | metacyclic. | Fernandes MC |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | amastigotes. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_129265)
Species | Accession | Gene Product |
---|---|---|
Leishmania braziliensis | LbrM.10.0380 | folate/biopterin transporter, putative |
Leishmania braziliensis | LbrM.10.0370 | folate/biopterin transporter, putative |
Leishmania braziliensis | LbrM.10.1460 | pteridine transporter, putative |
Leishmania braziliensis | LbrM.10.0020 | pteridin transporter, putative |
Leishmania braziliensis | LbrM.10.0410 | folate/biopterin transporter, putative |
Leishmania braziliensis | LbrM.10.0400 | folate/biopterin transporter, putative |
Leishmania braziliensis | LbrM.10.0390 | folate/biopterin transporter, putative |
Leishmania donovani | LdBPK_100360.1 | folate/biopterin transporter, putative |
Leishmania donovani | LdBPK_190870.1 | folate/biopterin transporter, putative |
Leishmania donovani | LdBPK_100370.1 | folate/biopterin transporter, putative |
Leishmania donovani | LdBPK_100420.1 | folate/biopterin transporter, putative |
Leishmania donovani | LdBPK_060310.1 | folate/biopterin transporter, putative |
Leishmania infantum | LinJ.19.0870 | folate/biopterin transporter, putative |
Leishmania infantum | LinJ.06.0310 | folate/biopterin transporter, putative |
Leishmania infantum | LinJ.10.0390 | folate/biopterin transporter, putative |
Leishmania infantum | LinJ.10.0360 | folate/biopterin transporter, putative |
Leishmania infantum | LinJ.10.0380 | folate/biopterin transporter, putative |
Leishmania infantum | LinJ.10.0370 | S-adenosylmethionine transporter |
Leishmania infantum | LinJ.10.1450 | pteridine transporter, putative |
Leishmania infantum | LinJ.10.0420 | folate/biopterin transporter, putative |
Leishmania infantum | LinJ.10.0400 | folate/biopterin transporter, putative |
Leishmania infantum | LinJ.10.0410 | folate/biopterin transporter, putative |
Leishmania major | LmjF.10.1310 | pteridine transporter, putative |
Leishmania major | LmjF.10.0370 | folate/biopterin transporter, putative |
Leishmania major | LmjF.06.0310 | folate/biopterin transporter, putative |
Leishmania major | LmjF.10.0380 | folate/biopterin transporter, putative |
Leishmania major | LmjF.10.0360 | folate/biopterin transporter, putative |
Leishmania major | LmjF.10.0020 | pteridin transporter, putative |
Leishmania major | LmjF.10.0385 | folate/biopterin transporter, putative |
Leishmania major | LmjF.19.0920 | folate/biopterin transporter, putative |
Leishmania major | LmjF.10.0400 | folate/biopterin transporter, putative |
Leishmania major | LmjF.10.0390 | folate/biopterin transporter, putative |
Leishmania mexicana | LmxM.10.1310 | pteridine transporter, putative |
Leishmania mexicana | LmxM.10.0380 | |
Leishmania mexicana | LmxM.06.0310 | pteridine transporter, putative |
Leishmania mexicana | LmxM.04.0020 | pteridine transporter (truncated), putative |
Leishmania mexicana | LmxM.10.0370 | folate/biopterin transporter, putative |
Leishmania mexicana | LmxM.10.0400 | pteridine transporter ft5, putative |
Leishmania mexicana | LmxM.10.0350 | pteridine transporter ft5, putative |
Leishmania mexicana | LmxM.19.0920 | pteridine transporter, putative |
Leishmania mexicana | LmxM.10.0360 | pteridine transporter ft6, putative |
Neospora caninum | NCLIV_039560 | BT1 transmembrane domain-containing protein, putative |
Neospora caninum | NCLIV_026780 | folate/methotrexate transporter, putative |
Trypanosoma brucei gambiense | Tbg972.8.3370 | folate transporter, putative,expression site-associated gene 10 (ESAG10) protein, putative |
Trypanosoma brucei gambiense | Tbg972.10.11110 | pteridine transporter, putative |
Trypanosoma brucei gambiense | Tbg972.8.3340 | folate transporter, putative,expression site-associated gene 10 (ESAG10) protein, putative |
Trypanosoma brucei gambiense | Tbg972.1.1710 | pteridine transporter, putative |
Trypanosoma brucei gambiense | Tbg972.1.1690 | pteridine transporter, putative |
Trypanosoma brucei gambiense | Tbg972.8.3350 | folate transporter, putative,expression site- associated gene 10 (ESAG10) protein, putative |
Trypanosoma brucei gambiense | Tbg972.1.1680 | pteridine transporter, putative |
Trypanosoma brucei | Tb927.8.3650 | folate transporter, putative |
Trypanosoma brucei | Tb11.v5.0766 | folate transporter, putative |
Trypanosoma brucei | Tb927.10.9080 | pteridine transporter, putative |
Trypanosoma brucei | Tb927.1.2820 | pteridine transporter, putative |
Trypanosoma brucei | Tb927.1.2880 | pteridine transporter, putative |
Trypanosoma brucei | Tb927.1.2850 | pteridine transporter, putative |
Trypanosoma brucei | Tb927.8.3620 | folate transporter, putative |
Trypanosoma brucei | Tb927.8.3630 | folate transporter, putative |
Trypanosoma congolense | TcIL3000_10_7850 | pteridine transporter, putative |
Trypanosoma congolense | TcIL3000_0_13340 | folate transporter, putative |
Trypanosoma congolense | TcIL3000_0_06950 | folate transporter, putative |
Trypanosoma cruzi | TcCLB.511575.130 | folate/pteridine transporter, putative |
Trypanosoma cruzi | TcCLB.508027.40 | folate/pteridine transporter, putative |
Trypanosoma cruzi | TcCLB.506633.90 | folate/pteridine transporter, putative |
Toxoplasma gondii | TGME49_260220 | folate/biopterin transporter subfamily protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.1.2820 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.1.2820 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.1.2820 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.1.2820 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.8.3620 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.3620 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.3620 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.3620 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.10.9080 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.9080 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.9080 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.9080 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_260220 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_260220 | Toxoplasma gondii | Essentiality uncertain | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from loss-of-function mutant phenotype (ECO:0000016) | Leishmania donovani | No drug identifiers listed for this gene. |
Annotator: | crowther@u.washington.edu. | Comment: | deletion of a folate transport gene led to lack of growth in media with pterins only (no folate). | References: | 2090944 2610143 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Leishmania major | biopterin transporter, putative;with=GeneDB:LinJ35_V3.5120 | 631 aa | 37.0% | 625 aa | Compounds | References |