Detailed view for LmjF.01.0240

Basic information

TDR Targets ID: 21411
Leishmania major, DNA excision/repair protein SNF2, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.2449 | Length (AA): 925 | MW (Da): 99076 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00176   SNF2 family N-terminal domain
PF00271   Helicase conserved C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0003676   nucleic acid binding  
GO:0005524   ATP binding  
GO:0004386   helicase activity  
GO:0003677   DNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
70 737 1z3i (X) 95 735 22.00 0 1 0.64 0.03
468 629 1t5i (A) 261 415 15.00 0.0000000011 0.36 0.43 -1.3
114 613 5jxr (A) 179 624 34.00 0 1 0.777541 0.35
115 711 1z3i (X) 141 698 29.00 0 1 0.831405 0.46
483 622 3ews (B) 320 459 19.00 0 0.5 0.397851 -0.68

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_131776)

Species Accession Gene Product
Arabidopsis thaliana AT5G63950   protein chromatin remodeling 24
Cryptosporidium hominis Chro.50081   hypothetical protein
Cryptosporidium parvum cgd5_2920   hypothetical protein
Dictyostelium discoideum DDB_G0288873   CHR group protein
Echinococcus granulosus EgrG_000704200   DNA excision repair protein ERCC 6
Entamoeba histolytica EHI_103660   helicase, putative
Echinococcus multilocularis EmuJ_000704200   DNA excision repair protein ERCC 6
Homo sapiens ENSG00000186871   excision repair cross-complementation group 6-like
Leishmania braziliensis LbrM.01.0280   DNA excision/repair protein SNF2, putative
Leishmania donovani LdBPK_010240.1   DNA excision/repair protein SNF2, putative
Leishmania infantum LinJ.01.0240   DNA excision/repair protein SNF2, putative
Leishmania major LmjF.01.0240   DNA excision/repair protein SNF2, putative
Leishmania mexicana LmxM.01.0240   DNA excision/repair protein SNF2, putative
Mus musculus 236930   excision repair cross-complementing rodent repair deficiency complementation group 6 like
Oryza sativa 9270485   Os10g0565700
Oryza sativa 4337517   Os04g0692700
Oryza sativa 9266414   Os04g0692750
Schistosoma japonicum Sjp_0042810   DNA excision repair protein ERCC-6-like, putative
Schistosoma mansoni Smp_166940   excision repair helicase ercc-6-related
Schmidtea mediterranea mk4.004959.00   DNA excision repair protein ERCC-6-like
Trypanosoma cruzi TcCLB.511577.60   DNA excision/repair protein SNF2, putative
Trypanosoma cruzi TcCLB.504797.70   DNA excision/repair protein SNF2, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.01.0240 (Leishmania major), DNA excision/repair protein SNF2, putative
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