pI: 7.6845 |
Length (AA): 211 |
MW (Da): 23570 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 209 | 1cjb (A) | 19 | 228 | 22.00 | 0 | 1 | 1.28 | -1.5 |
20 | 202 | 1pzm (A) | 20 | 202 | 93.00 | 0 | 1 | 2.07 | -2.5 |
20 | 202 | 1pzm (A) | 20 | 202 | 93.00 | 0 | 1 | 1.9789 | -1.58 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | amastigotes, metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_127374)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G71750 | hypoxanthine phosphoribosyltransferase |
Brugia malayi | Bm1_19890 | Phosphoribosyl transferase domain containing protein |
Caenorhabditis elegans | CELE_Y105E8B.5 | Protein Y105E8B.5 |
Dictyostelium discoideum | DDB_G0285193 | hypoxanthine phosphoribosyltransferase |
Escherichia coli | b0125 | hypoxanthine phosphoribosyltransferase |
Echinococcus granulosus | EgrG_000758800 | hypoxanthine guanine phosphoribosyltransferase |
Echinococcus granulosus | EgrG_000758900 | hypoxanthine guanine phosphoribosyltransferase |
Echinococcus multilocularis | EmuJ_000758900 | hypoxanthine guanine phosphoribosyltransferase |
Echinococcus multilocularis | EmuJ_000758800 | hypoxanthine guanine phosphoribosyltransferase |
Giardia lamblia | GL50803_6436 | Guanine phosphoribosyltransferase |
Homo sapiens | ENSG00000099256 | phosphoribosyl transferase domain containing 1 |
Homo sapiens | ENSG00000165704 | hypoxanthine phosphoribosyltransferase 1 |
Leishmania braziliensis | LbrM.21.0990 | hypoxanthine-guanine phosphoribosyltransferase |
Leishmania braziliensis | LbrM.21.1000 | xanthine phosphoribosyltransferase |
Leishmania donovani | LdBPK_210990.1 | xanthine phosphoribosyltransferase |
Leishmania donovani | LdBPK_210980.1 | hypoxanthine-guanine phosphoribosyltransferase |
Leishmania infantum | LinJ.21.0990 | xanthine phosphoribosyltransferase |
Leishmania infantum | LinJ.21.0980 | hypoxanthine-guanine phosphoribosyltransferase |
Leishmania major | LmjF.21.0845 | hypoxanthine-guanine phosphoribosyltransferase |
Leishmania major | LmjF.21.0850 | xanthine phosphoribosyltransferase |
Leishmania mexicana | LmxM.21.0850 | xanthine phosphoribosyltransferase |
Leishmania mexicana | LmxM.21.0845 | hypoxanthine-guanine phosphoribosyltransferase |
Mycobacterium leprae | ML0214 | Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho |
Mus musculus | ENSMUSG00000025630 | hypoxanthine guanine phosphoribosyl transferase |
Mycobacterium tuberculosis | Rv3624c | Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor |
Mycobacterium ulcerans | MUL_4200 | hypoxanthine-guanine phosphoribosyltransferase Hpt |
Neospora caninum | NCLIV_038170 | Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8), related |
Onchocerca volvulus | OVOC11850 |
|
Plasmodium berghei | PBANKA_1210800 | hypoxanthine-guanine phosphoribosyltransferase, putative |
Plasmodium falciparum | PF3D7_1012400 | hypoxanthine-guanine phosphoribosyltransferase |
Plasmodium knowlesi | PKNH_0812200 | hypoxanthine-guanine phosphoribosyltransferase, putative |
Plasmodium vivax | PVX_094840 | hypoxanthine-guanine phosphoribosyltransferase, putative |
Schistosoma japonicum | Sjp_0023450 | Hypoxanthine-guanine phosphoribosyltransferase, putative |
Schistosoma japonicum | Sjp_0023460 | ko:K00760 hypoxanthine phosphoribosyltransferase [EC2.4.2.8], putative |
Schistosoma mansoni | Smp_168500 | hypoxanthine-guanine phosphoribosyltransferase |
Schistosoma mansoni | Smp_103560 | hypoxanthine-guanine phosphoribosyltransferase |
Schmidtea mediterranea | mk4.002646.06 | |
Schmidtea mediterranea | mk4.000023.23 | |
Schmidtea mediterranea | mk4.005084.05 | |
Schmidtea mediterranea | mk4.016658.00 | |
Schmidtea mediterranea | mk4.016685.01 | |
Schmidtea mediterranea | mk4.013413.00 | |
Schmidtea mediterranea | mk4.001970.04 | |
Schmidtea mediterranea | mk4.010510.00 | |
Trypanosoma brucei gambiense | Tbg972.10.1690 | hypoxanthine-guanine phosphoribosyltransferase, putative |
Trypanosoma brucei gambiense | Tbg972.10.1600 | hypoxanthine-guanine phosphoribosyltransferase, putative |
Trypanosoma brucei gambiense | Tbg972.10.1590 | hypoxanthine-guanine phosphoribosyltransferase, putative |
Trypanosoma brucei | Tb927.10.1400 | hypoxanthine-guanine phosphoribosyltransferase |
Trypanosoma brucei | Tb927.10.1470 | hypoxanthine-guanine phosphoribosyltransferase |
Trypanosoma brucei | Tb927.10.1390 | hypoxanthine-guanine phosphoribosyltransferase, putative |
Trypanosoma congolense | TcIL3000_10_1180 | hypoxanthine-guanine phosphoribosyltransferase, putative |
Trypanosoma congolense | TcIL3000_10_1280 | hypoxanthine-guanine phosphoribosyltransferase |
Trypanosoma congolense | TcIL3000_10_1170 | hypoxanthine-guanine phosphoribosyltransferase, putative |
Trypanosoma cruzi | TcCLB.509693.80 | hypoxanthine-guanine phosphoribosyltransferase, putative |
Trypanosoma cruzi | TcCLB.506457.40 | hypoxanthine-guanine phosphoribosyltransferase, putative |
Trypanosoma cruzi | TcCLB.509693.70 | hypoxanthine-guanine phosphoribosyltransferase, putative |
Trypanosoma cruzi | TcCLB.506457.30 | hypoxanthine-guanine phosphoribosyltransferase, putative |
Toxoplasma gondii | TGME49_200320 | hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT |
Trichomonas vaginalis | TVAG_243770 | hypoxanthine-guanine phosphoribosyltransferase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.1390 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.1390 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.1390 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.10.1390 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.10.1400 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.1400 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.1400 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.1400 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0125 | Escherichia coli | non-essential | goodall |
PBANKA_1210800 | Plasmodium berghei | Slow | plasmo |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.8
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | Compounds | References |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | Compounds | References |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | Compounds | References |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | Compounds | References |
Homo sapiens | hypoxanthine phosphoribosyltransferase 1 | Compounds | References |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | Compounds | References |
Plasmodium falciparum | hypoxanthine-guanine phosphoribosyltransferase | Compounds | References |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | Compounds | References |
Plasmodium vivax | hypoxanthine-guanine phosphoribosyltransferase, putative | Compounds | References |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | Compounds | References |
Target | Type | Source | Notes |
---|---|---|---|
LmjF.21.0845 | cloned gene | BRENDA | A gene with this EC number or name or sequence has been cloned from Leishmania donovani ( 2 ) |