A chemogenomics resource for neglected tropical diseases
TDR Targets ID: 232904 Wolbachia endosymbiont of Brugia malayi, 50S ribosomal protein L5 Source Database / ID: GenBank / Wbm0329
pI: 9.9366 | Length (AA): 177 | MW (Da): 20107 | Number of Paralogs: 0
EC number(s): No EC number(s) registered for this gene.
Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: ND
[DGPI v2.04]
No Pfam domain information for this protein.
Component: (mouse over links to read term descriptions)
Function: (mouse over links to read term descriptions)
Process: (mouse over links to read term descriptions)
Ribosome (KEGG)
No functional classes assigned to this gene.
Modbase 3D models: Wbm0329
PDB structures: no structure available for this protein in the PDB.
No expression information available for this gene.
Number of putative antigenic epitopes: 9 Cumulative epitope score: 10.1 Normalized epitope score: 5.7 Percentile: 87.8 (this protein belongs to the top 12.2% proteins in the genome of Wolbachia endosymbiont of Brugia malayi, based on the predicted antigenicity).
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Putative antigenic peptides were predicted using the method of Kolaskar and Tongaonkar, as implemented in EMBOSS (antigenic). Each predicted epitope has an associated score based on the physicochemical properties of the aminoacid residues. A cumulative antigenicity score was calculated as the sum of scores of all predicted epitopes in the protein. A normalized antigenicity index was calculated as the ratio of this cumulative score over the protein length. Finally, for each of these normalized antigenicity index values we calculated the percent of proteins for each genome that fall below it. Thus a protein with an antigenicity index percentile of 80 means that 80% of the proteins of the genome have a lower normalized antigenicity index score (i.e. this protein is amongst the top 20% of the proteins in these genome in terms of predicted antigenicity).
OrthoMCL 4 cluster: OG4_10156 Number of Paralogs: 0
Ortholog group members from selected species: Arabidopsis thaliana NP_567563 RPL16B; structural constituent of ribosome ... | OrthoMCL Arabidopsis thaliana NP_191429 60S ribosomal protein L11 (RPL11B) ... | OrthoMCL Arabidopsis thaliana NP_192040 ribosomal protein L5 family protein ... | OrthoMCL Arabidopsis thaliana NP_851137 60S ribosomal protein L11 (RPL11D) ... | OrthoMCL Arabidopsis thaliana NP_850376 RPL16A; structural constituent of ribosome ... | OrthoMCL Arabidopsis thaliana NP_568649 60S ribosomal protein L11 (RPL11D) ... | OrthoMCL Babesia bovis XP_001610475.1 60S ribosomal protein L11 ... | OrthoMCL Brugia malayi Bm1_04440 60S ribosomal protein L11, putative... | OrthoMCL Caenorhabditis elegans F07D10.1 CE07033 WBGene00004423 locus:rpl-11.2 ribosomal protein stat... | OrthoMCL Caenorhabditis elegans T22F3.4 CE13968 WBGene00004422 locus:rpl-11.1 60S ribososmal protein... | OrthoMCL Cryptosporidium hominis Chro.60255 ribosomal protein L11 ... | OrthoMCL Cryptosporidium muris CMU_007700 60S ribosomal protein L11, putative ... | OrthoMCL Cryptosporidium neoformas XP_567416 60s ribosomal protein l11 ... | OrthoMCL Cryptosporidium neoformas XP_569508 60s ribosomal protein l7, mitochondrial precursor ... | OrthoMCL Cryptosporidium parvum cgd6_2170 60S ribosomal protein L11 ... | OrthoMCL Drosophila melanogaster FBpp0085717 | OrthoMCL Escherichia coli K12 NP_417767.1 50S ribosomal protein L5 [Escherichia coli K12]... | OrthoMCL Giardia intestinalis GL50581_3003 Ribosomal protein L11 ... | OrthoMCL Giardia lamblia GLP15_2156 Ribosomal protein L11 ... | OrthoMCL Homo sapiens ENSP00000363676 | OrthoMCL Leishmania braziliensis LbrM04_V2.0520 | OrthoMCL Leishmania braziliensis LbrM22_V2.0030 | OrthoMCL Leishmania infantum LinJ04_V3.0460 | OrthoMCL Leishmania infantum LinJ22_V3.0004 | OrthoMCL Leishmania major LmjF22.0030 60S ribosomal protein L11 (L5, L16)... | OrthoMCL Leishmania major LmjF04.0470 60S ribosomal protein L11 (L5, L16)... | OrthoMCL Leishmania mexicana LmxM22.0030 | OrthoMCL Leishmania mexicana LmxM04.0470 | OrthoMCL Mycobacterium leprae strain TN ML1847c PROBABLE 50S RIBOSOMAL PROTEIN L5 RPLE... | OrthoMCL Mus musculus ENSMUSP00000081663 | OrthoMCL Mus musculus ENSMUSP00000078670 | OrthoMCL Mus musculus ENSMUSP00000078001 | OrthoMCL Mycobacterium tuberculosis Rv0716 PROBABLE 50S RIBOSOMAL PROTEIN L5 RPLE... | OrthoMCL Neospora caninum NCLIV_053950 | OrthoMCL Oryza sativa NP_001054899 Os05g0207300 ... | OrthoMCL Oryza sativa NP_001042339 Os01g0205500 ... | OrthoMCL Oryza sativa NP_001046386 Os02g0235600 ... | OrthoMCL Oryza sativa NP_001048814 Os03g0125000 ... | OrthoMCL Oryza sativa NP_001057834 Os06g0550000 ... | OrthoMCL Plasmodium berghei PB001409.02.0 60S ribosomal protein L11a, putative ... | OrthoMCL Plasmodium chabaudi PCAS_061760 60S ribosomal protein L11a, putative ... | OrthoMCL P. falciparum 3D7 PF07_0079 60S ribosomal protein L11a, putative... | OrthoMCL Plasmodium knowlesi PKH_031340 60S ribosomal protein L11a, putative ... | OrthoMCL Plasmodium vivax PVX_096340 60S ribosomal protein L11, putative... | OrthoMCL Plasmodium yoelii PY02461 ribosomal protein L11-like ... | OrthoMCL Saccharomyces cerevisiae YGR085C RPL11B SGDID:S000003317, Chr VII from 648911-648387, reverse... | OrthoMCL Saccharomyces cerevisiae YPR102C RPL11A SGDID:S000006306, Chr XVI from 731746-731222, reverse... | OrthoMCL Saccharomyces cerevisiae YDR237W MRPL7 SGDID:S000002645, Chr IV from 936611-937489, Verified ... | OrthoMCL Schistosoma mansoni Smp_050940.2 60S ribosomal protein L11, putative... | OrthoMCL Schistosoma mansoni Smp_050940.1 60S ribosomal protein L11, putative... | OrthoMCL Trypanosoma brucei gambiense Tbg972.9.4150 | OrthoMCL Trypanosoma brucei gambiense Tbg972.9.4140 | OrthoMCL Trypanosoma brucei Tb09.160.5580 60S ribosomal protein L11, putative... | OrthoMCL Trypanosoma brucei Tb09.160.5590 60S ribosomal protein L11, putative... | OrthoMCL Trypanosoma congolense TcIL3000.0.18940 | OrthoMCL Trypanosoma congolense TcIL3000.0.18950 | OrthoMCL Trypanosoma cruzi Tc00.1047053508197.10 60S ribosomal protein L11, putative... | OrthoMCL Toxoplasma gondii TGME49_109820 ribosomal protein L11, putative... | OrthoMCL Trypanosoma vivax TvY486_0902930 | OrthoMCL Wolbachia endosymbiont of Brugia malayi Wbm0329 (this record). 50S ribosomal protein L5... | OrthoMCL
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Curated from literature
No chemical compounds is associated to this gene
Predicted associations
By orthology to known druggable targets
By sequence similarity to non orthologous druggable targets
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
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Gene identifier: Wbm0329 Wolbachia endosymbiont of Brugia malayi, 50S ribosomal protein L5
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