pI: 7.8404 |
Length (AA): 361 |
MW (Da): 40280 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
59 | 245 | 4wfq (A) | 119 | 309 | 34.00 | 0.0021 | 1 | 1.11441 | -1.99 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127799)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G05055 | transcription initiation factor TFIIH subunit H2 |
Babesia bovis | BBOV_IV001810 | transcriptional factor 2 subunit |
Brugia malayi | Bm1_30170 | TFIIH basal transcription factor complex p44 subunit, putative |
Candida albicans | CaO19.1457 | subunit of transcription factor TF2H |
Candida albicans | CaO19.9032 | subunit of transcription factor TF2H |
Caenorhabditis elegans | CELE_T16H12.4 | Protein T16H12.4 |
Cryptosporidium hominis | Chro.30353 | hypothetical protein |
Cryptosporidium parvum | cgd3_3110 | transcription factor TFIIH with a vWA domain |
Dictyostelium discoideum | DDB_G0272362 | TFIIH subunit |
Drosophila melanogaster | Dmel_CG11115 | Suppressor of Stem-Loop mutation ortholog (S. cerevisiae) |
Echinococcus granulosus | EgrG_000495100 | TFIIH C1 C terminal |
Entamoeba histolytica | EHI_182880 | TFIIH basal transcription factor complex subunit, putative |
Echinococcus multilocularis | EmuJ_000495100 | TFIIH C1, C terminal |
Giardia lamblia | GL50803_15000 | TFIIH P44 |
Homo sapiens | ENSG00000183474 | GTF2H2 family member C |
Homo sapiens | ENSG00000145736 | general transcription factor IIH, polypeptide 2, 44kDa |
Homo sapiens | 730394 | GTF2H2 family member C, copy 2 |
Leishmania braziliensis | LbrM.24.1740 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_241750.1 | Ssl1-like, putative |
Leishmania infantum | LinJ.24.1750 | hypothetical protein, conserved |
Leishmania major | LmjF.24.1680 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.24.1680 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_05169 | hypothetical protein |
Mus musculus | ENSMUSG00000021639 | general transcription factor II H, polypeptide 2 |
Neospora caninum | NCLIV_001790 | general transcription factor IIH polypeptide 2, putative |
Oryza sativa | 4336358 | Os04g0508900 |
Onchocerca volvulus | OVOC12467 | General transcription factor IIH subunit 2 homolog |
Plasmodium berghei | PBANKA_1413400 | general transcription factor IIH subunit 2, putative |
Plasmodium falciparum | PF3D7_1314900 | general transcription factor IIH subunit 2 |
Plasmodium knowlesi | PKNH_1415600 | general transcription factor IIH subunit 2, putative |
Plasmodium vivax | PVX_122565 | general transcription factor IIH subunit 2, putative |
Plasmodium yoelii | PY06921 | W43325 comes from this gene., putative |
Saccharomyces cerevisiae | YLR005W | TFIIH/NER complex subunit SSL1 |
Schistosoma japonicum | Sjp_0310460 | ko:K03142 transcription initiation factor TFIIH subunit H2, putative |
Schistosoma japonicum | Sjp_0219370 | General transcription factor IIH subunit 2, putative |
Schistosoma mansoni | Smp_136520 | btf |
Schmidtea mediterranea | mk4.001077.02 | General transcription factor IIH subunit 2 |
Trypanosoma brucei gambiense | Tbg972.8.6640 | DNA repair and transcription factor protein, putative |
Trypanosoma brucei | Tb927.8.6540 | TFIIH basal transcription factor subunit |
Trypanosoma congolense | TcIL3000_8_6380 | DNA repair and transcription factor protein, putative |
Trypanosoma cruzi | TcCLB.511907.300 | transcription factor II H complex, SSL1 subunit, putative |
Toxoplasma gondii | TGME49_294920 | general transcription factor IIH polypeptide 2 GTF2H2 |
Theileria parva | TP03_0481 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_290240 | ssl1, putative |
Trichomonas vaginalis | TVAG_100760 | ssl1, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.6540 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.6540 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.6540 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.6540 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T16H12.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T16H12.4 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_T16H12.4 | Caenorhabditis elegans | slow growth | wormbase |
YLR005W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1413400 | Plasmodium berghei | Essential | plasmo |
TGME49_294920 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Leishmania donovani | Beta tubulin | 43 aa | 26.8% | 41 aa | Compounds | References |