Detailed view for Bm1_36335

Basic information

TDR Targets ID: 233462
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 10.6096 | Length (AA): 112 | MW (Da): 12554 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF09072   Translation machinery associated TMA7

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
60 101 2nca (A) 40 81 24.00 0.26 0.05 0.7223 -1.12
61 106 1ey0 (A) 45 89 40.00 0.13 0.22 0.755814 0.51

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130213)

Species Accession Gene Product
Arabidopsis thaliana AT1G15270   translation machinery associated protein TMA7
Arabidopsis thaliana AT3G16040   translation machinery associated TMA7
Brugia malayi Bm1_36335   hypothetical protein
Caenorhabditis elegans CELE_F49C12.11   Protein F49C12.11
Drosophila melanogaster Dmel_CG16824   CG16824 gene product from transcript CG16824-RA
Drosophila melanogaster Dmel_CG13364   CG13364 gene product from transcript CG13364-RA
Echinococcus granulosus EgrG_000170500   Translation machinery associated TMA7
Echinococcus multilocularis EmuJ_000170500   Translation machinery associated TMA7
Homo sapiens ENSG00000232112   translation machinery associated 7 homolog (S. cerevisiae)
Leishmania braziliensis LbrM.30.2720   hypothetical protein, conserved
Leishmania donovani LdBPK_302760.1   Translation machinery associated TMA7, putative
Leishmania infantum LinJ.30.2760   hypothetical protein, conserved
Leishmania major LmjF.30.2760   hypothetical protein, conserved
Leishmania mexicana LmxM.29.2760   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_02556   hypothetical protein
Mus musculus 66167   translational machinery associated 7 homolog (S. cerevisiae)
Saccharomyces cerevisiae YLR262C-A   Tma7p
Schistosoma japonicum Sjp_0212420   IPR015157,Translation machinery associated TMA7,domain-containing
Schistosoma mansoni Smp_169920   Translation machinery-associated protein
Schmidtea mediterranea mk4.000004.08   Putative translation machinery-associated protein
Trypanosoma brucei gambiense Tbg972.6.3790   hypothetical protein, conserved
Trypanosoma brucei Tb927.6.4010   Translation machinery associated TMA7, putative
Trypanosoma cruzi TcCLB.511521.24   Translation machinery associated TMA7, putative
Trypanosoma cruzi TcCLB.511737.9   Translation machinery associated TMA7, putative
Trypanosoma cruzi TcCLB.511735.79   Translation machinery associated TMA7, putative
Trypanosoma cruzi TcCLB.511519.18   Translation machinery associated TMA7, putative

Essentiality

Bm1_36335 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.4010 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.6.4010 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.6.4010 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.6.4010 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F49C12.11 Caenorhabditis elegans embryonic lethal wormbase
CELE_F49C12.11 Caenorhabditis elegans larval arrest wormbase
CELE_F49C12.11 Caenorhabditis elegans larval lethal wormbase
CELE_F49C12.11 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_36335 (Brugia malayi), hypothetical protein
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