Detailed view for Bm1_51940

Basic information

TDR Targets ID: 233681
Brugia malayi, Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit,epsilon isoform
Source Database / ID:  GenBank

pI: 8.0374 | Length (AA): 521 | MW (Da): 59722 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01603   Protein phosphatase 2A regulatory B subunit (B56 family)

Gene Ontology

Mouse over links to read term descriptions.
GO:0019888   protein phosphatase regulator activity  
GO:0000159   protein phosphatase type 2A complex  
GO:0008601   protein phosphatase type 2A regulator activity  
GO:0005488   binding  
GO:0007165   signal transduction  

Metabolic Pathways

mRNA surveillance pathway (KEGG)
Wnt signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
62 492 1qbk (B) 468 890 9.00 0 1 0.962355 -0.22
68 459 3fga (B) 24 426 70.00 0 1 1.6255 -1.25

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126813)

Species Accession Gene Product
Arabidopsis thaliana AT1G13460   protein phosphatase 2A B'theta
Arabidopsis thaliana AT3G21650   protein phosphatase 2A B'zeta
Arabidopsis thaliana AT3G26030   serine/threonine protein phosphatase 2A B'55 delta
Arabidopsis thaliana AT4G15415   protein phosphatase 2A B'gamma
Arabidopsis thaliana AT3G09880   serine/threonine protein phosphatase 2A regulatory subunit B prime beta isoform
Arabidopsis thaliana AT5G03470   protein phosphatase 2A B' alpha
Arabidopsis thaliana AT3G26020   protein phosphatase 2A regulatory subunit B' eta
Arabidopsis thaliana AT3G54930   protein phosphatase 2A B'epsilon
Babesia bovis BBOV_IV000610   protein phosphatase B regulatory subunit, putative
Brugia malayi Bm1_24125   delta isoform of regulatory subunit B56, protein phosphatase 2A
Brugia malayi Bm1_51940   Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit,epsilon isoform
Candida albicans CaO19.20   probable regulatory subunit B of protein serine/threonine phosphatase 2A (PP2A) similar to S. cerevisiae RTS1 (YOR014W)
Candida albicans CaO19.7691   probable regulatory subunit B of protein serine/threonine phosphatase 2A (PP2A) similar to S. cerevisiae RTS1 (YOR014W)
Caenorhabditis elegans CELE_W08G11.4   Protein PPTR-1
Caenorhabditis elegans CELE_C13G3.3   Protein PPTR-2, isoform A
Cryptosporidium parvum cgd4_290   putative protein phosphatase 2A regulatory B subunit
Dictyostelium discoideum DDB_G0280469   protein phosphatase 2A regulatory subunit
Drosophila melanogaster Dmel_CG5643   widerborst
Drosophila melanogaster Dmel_CG7913   CG7913 gene product from transcript CG7913-RK
Echinococcus granulosus EgrG_000253800   protein phosphatase 2a regulatory subunit
Echinococcus granulosus EgrG_000256400   serine:threonine protein phosphatase 2A 56 kDa
Echinococcus granulosus EgrG_000543500   serine:threonine protein phosphatase 2A 56 kDa
Echinococcus multilocularis EmuJ_000256400   serine:threonine protein phosphatase 2A 56 kDa
Echinococcus multilocularis EmuJ_000543500   serine:threonine protein phosphatase 2A 56 kDa
Echinococcus multilocularis EmuJ_000253800   protein phosphatase 2a regulatory subunit
Giardia lamblia GL50803_16443   Protein phosphatase 2A B regulatory subunit Wdb1
Homo sapiens ENSG00000154001   protein phosphatase 2, regulatory subunit B', epsilon isoform
Homo sapiens ENSG00000078304   protein phosphatase 2, regulatory subunit B', gamma
Homo sapiens ENSG00000066027   protein phosphatase 2, regulatory subunit B', alpha
Homo sapiens ENSG00000112640   protein phosphatase 2, regulatory subunit B', delta
Homo sapiens ENSG00000068971   protein phosphatase 2, regulatory subunit B', beta
Loa Loa (eye worm) LOAG_03069   hypothetical protein
Loa Loa (eye worm) LOAG_07224   protein phosphatase 2A regulatory subunit B' delta isoform
Mus musculus ENSMUSG00000026626   protein phosphatase 2, regulatory subunit B', alpha
Mus musculus ENSMUSG00000024777   protein phosphatase 2, regulatory subunit B', beta
Mus musculus ENSMUSG00000021051   protein phosphatase 2, regulatory subunit B', epsilon
Mus musculus ENSMUSG00000017843   protein phosphatase 2, regulatory subunit B', gamma
Mus musculus ENSMUSG00000059409   protein phosphatase 2, regulatory subunit B', delta
Neospora caninum NCLIV_063300   GE25516, related
Oryza sativa 4344549   Os08g0122000
Oryza sativa 4334757   Os03g0844500
Oryza sativa 4333730   Os03g0681800
Oryza sativa 4342912   Os07g0274800
Oryza sativa 4336207   Os04g0485100
Saccharomyces cerevisiae YOR014W   protein phosphatase 2A regulatory subunit RTS1
Schistosoma japonicum Sjp_0300840   similar to Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, putative
Schistosoma japonicum Sjp_0094500   similar to Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform, putative
Schistosoma mansoni Smp_035430.2   protein phosphatase 2a regulatory subunit
Schistosoma mansoni Smp_176600   protein phosphatase 2a regulatory subunit
Schistosoma mansoni Smp_035430.1   protein phosphatase 2a regulatory subunit
Schmidtea mediterranea mk4.034100.00  
Schmidtea mediterranea mk4.018632.01  
Schmidtea mediterranea mk4.004655.01   PP2A-B'
Schmidtea mediterranea mk4.006023.00  
Schmidtea mediterranea mk4.000267.16  
Schmidtea mediterranea mk4.013000.02  
Schmidtea mediterranea mk4.004914.00  
Schmidtea mediterranea mk4.016800.00  
Schmidtea mediterranea mk4.010523.00  
Schmidtea mediterranea mk4.006276.00   PP2A-B'
Schmidtea mediterranea mk4.000267.15  
Schmidtea mediterranea mk4.000000.02  
Schmidtea mediterranea mk4.007282.00  
Toxoplasma gondii TGME49_246510   protein phosphatase 2a regulatory b subunit (b56 family) protein
Theileria parva TP01_0084   hypothetical protein
Trichomonas vaginalis TVAG_024680   protein phosphatase 2A, regulatory subunit, putative
Trichomonas vaginalis TVAG_233070   protein phosphatase 2A, regulatory subunit, putative

Essentiality

Bm1_51940 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C13G3.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_C13G3.3 Caenorhabditis elegans larval arrest wormbase
CELE_W08G11.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_W08G11.4 Caenorhabditis elegans slow growth wormbase
TGME49_246510 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens protein phosphatase 2, regulatory subunit B', alpha Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_51940 (Brugia malayi), Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit,epsilon isoform
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