Detailed view for Bm1_40085

Basic information

TDR Targets ID: 233711
Brugia malayi, Patatin-like phospholipase family protein
Source Database / ID:  GenBank

pI: 5.7364 | Length (AA): 1017 | MW (Da): 113329 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00023   Ankyrin repeat
PF01734   Patatin-like phospholipase
PF12796   Ankyrin repeats (3 copies)
PF13857   Ankyrin repeats (many copies)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0008152   metabolic process  
GO:0006629   lipid metabolic process  

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
272 569 4rly (A) 1117 2320 28.00 0 1 0.592119 -0.27
449 572 1n0r (A) 2 125 36.00 0 1 0.694027 -1.2
474 550 3aaa (C) 27 103 30.00 0.09 1 0.623813 -1.56
515 567 2etb (A) 164 229 42.00 0.18 0.99 0.410214 -0.87
663 880 4pk9 (A) 27 261 28.00 0.0000082 0.95 0.297456 0.34
665 1002 4pk9 (A) 29 382 20.00 0 1 0.53375 -0.03

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133095)

Species Accession Gene Product
Brugia malayi Bm1_40085   Patatin-like phospholipase family protein
Caenorhabditis elegans CELE_F47A4.5   Protein F47A4.5
Caenorhabditis elegans CELE_W07A8.2a   Protein W07A8.2, isoform D
Caenorhabditis elegans CELE_W07A8.2   Protein W07A8.2, isoform C
Drosophila melanogaster Dmel_CG6718   calcium-independent phospholipase A2 VIA
Echinococcus granulosus EgrG_000492900   calcium independent phospholipase A2 VIA
Echinococcus multilocularis EmuJ_000492900   calcium independent phospholipase A2 VIA
Homo sapiens ENSG00000184381   phospholipase A2, group VI (cytosolic, calcium-independent)
Loa Loa (eye worm) LOAG_05453   hypothetical protein
Loa Loa (eye worm) LOAG_07280   hypothetical protein
Mus musculus ENSMUSG00000042632   phospholipase A2, group VI
Schistosoma japonicum Sjp_0110770   Conserved hypothetical protein
Schistosoma japonicum Sjp_0206930   ko:K01047 phospholipase A2 [EC3.1.1.4], putative
Schistosoma japonicum Sjp_0206940   similar to 85 kDa calcium-independent phospholipase A2, putative
Schistosoma mansoni Smp_133290   phospholipase
Schmidtea mediterranea mk4.039483.00   85/88 kDa calcium-independent phospholipase A2
Schmidtea mediterranea mk4.025976.00  
Schmidtea mediterranea mk4.008782.01   85/88 kDa calcium-independent phospholipase A2

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_40085 (Brugia malayi), Patatin-like phospholipase family protein
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