Detailed view for Bm1_20950

Basic information

TDR Targets ID: 233775
Brugia malayi, vesicular GABA transporter
Source Database / ID:  GenBank

pI: 6.0877 | Length (AA): 463 | MW (Da): 51973 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 10

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01490   Transmembrane amino acid transporter protein

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
88 455 3gia (A) 25 401 12.00 0 0.14 0.788716 -0.17
88 420 3l1l (A) 27 376 19.00 0 0.52 0.789122 0.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128762)

Species Accession Gene Product
Arabidopsis thaliana AT3G09330   transmembrane amino acid transporter-like protein
Arabidopsis thaliana AT5G02180   transmembrane amino acid transporter family protein
Arabidopsis thaliana AT5G02170   transmembrane amino acid transporter family protein
Arabidopsis thaliana AT3G54830   transmembrane amino acid transporter family protein
Arabidopsis thaliana AT2G41190   transmembrane amino acid transporter family protein
Arabidopsis thaliana AT3G09340   transmembrane amino acid transporter-like protein
Arabidopsis thaliana AT2G39130   transmembrane amino acid transporter
Brugia malayi Bm1_20950   vesicular GABA transporter
Candida albicans CaO19_7100   hypothetical protein
Candida albicans CaO19.7100   similar to transmembrane amino acid transporter that controls vacuolar uptake of large neutral amino acids
Caenorhabditis elegans CELE_T20G5.6   Protein UNC-47
Drosophila melanogaster Dmel_CG8394   Vesicular GABA Transporter
Homo sapiens ENSG00000101438   solute carrier family 32 (GABA vesicular transporter), member 1
Loa Loa (eye worm) LOAG_15714   hypothetical protein
Loa Loa (eye worm) LOAG_16136   hypothetical protein
Loa Loa (eye worm) LOAG_15044   hypothetical protein
Loa Loa (eye worm) LOAG_16089   hypothetical protein
Mus musculus ENSMUSG00000037771   solute carrier family 32 (GABA vesicular transporter), member 1
Oryza sativa 4327977   Os02g0101000
Oryza sativa 4352600   Os12g0574000
Oryza sativa 4336049   Os04g0460300
Oryza sativa 9269491   Os04g0201500
Saccharomyces cerevisiae YJR001W   Avt1p
Schmidtea mediterranea mk4.000128.07  
Schmidtea mediterranea mk4.025164.01  
Schmidtea mediterranea mk4.001827.05   Vesicular GABA transporter

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_20950 (Brugia malayi), vesicular GABA transporter
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