Detailed view for Bm1_53075

Basic information

TDR Targets ID: 233814
Brugia malayi, Synaptobrevin
Source Database / ID:  GenBank

pI: 9.7166 | Length (AA): 109 | MW (Da): 12091 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00957   Synaptobrevin

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0016192   vesicle-mediated transport  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 106 2kog (A) 12 114 71.00 0 0.41 1.46763 2.3
47 80 1urq (A) 1075 1108 44.00 0.13 0.24 0.937727 -1.71

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126859)

Species Accession Gene Product
Babesia bovis BBOV_I001900   conserved hypothetical protein
Brugia malayi Bm1_53075   Synaptobrevin
Caenorhabditis elegans CELE_B0513.9   Protein VAMP-8, isoform A
Caenorhabditis elegans CELE_T10H9.4   Protein SNB-1
Caenorhabditis elegans CELE_F23H12.1   Protein SNB-2
Cryptosporidium parvum cgd3_1070   synaptobrevin like SNARE
Cryptosporidium parvum cgd3_1080   hypothetical protein
Dictyostelium discoideum DDB_G0284951   longin domain-containing protein
Dictyostelium discoideum DDB_G0280061   synaptobrevin domain-containing protein
Dictyostelium discoideum DDB_G0290363   synaptobrevin domain-containing protein
Drosophila melanogaster Dmel_CG17248   neuronal Synaptobrevin
Drosophila melanogaster Dmel_CG12210   Synaptobrevin
Echinococcus granulosus EgrG_000479200   expressed protein
Echinococcus granulosus EgrG_000528000   vesicle associated membrane protein
Echinococcus granulosus EgrG_000201000   synaptobrevin
Echinococcus granulosus EgrG_000494400   vesicle associated membrane protein
Entamoeba histolytica EHI_069370   vesicle-associated membrane protein, putative
Entamoeba histolytica EHI_098490   vesicle-associated membrane protein, putative
Entamoeba histolytica EHI_170630   vesicle-associated membrane protein, putative
Echinococcus multilocularis EmuJ_000201000   synaptobrevin
Echinococcus multilocularis EmuJ_000494400   vesicle associated membrane protein
Echinococcus multilocularis EmuJ_000528000   vesicle associated membrane protein
Echinococcus multilocularis EmuJ_000479200   expressed protein
Homo sapiens ENSG00000049245   vesicle-associated membrane protein 3
Homo sapiens ENSG00000118640   vesicle-associated membrane protein 8
Homo sapiens ENSG00000139190   vesicle-associated membrane protein 1 (synaptobrevin 1)
Homo sapiens ENSG00000220205   vesicle-associated membrane protein 2 (synaptobrevin 2)
Homo sapiens ENSG00000117533   vesicle-associated membrane protein 4
Leishmania braziliensis LbrM.08.0030   vesicle-associated membrane protein, putative
Leishmania braziliensis LbrM.21.1490   vesicule-associated membrane protein, putative
Leishmania donovani LdBPK_080030.1   vesicle-associated membrane protein, putative
Leishmania donovani LdBPK_211530.1   vesicle-associated membrane protein, putative
Leishmania infantum LinJ.08.0030   vesicle-associated membrane protein, putative
Leishmania infantum LinJ.21.1530   vesicule-associated membrane protein, putative
Leishmania major LmjF.21.1290   R-SNARE protein, putative
Leishmania major LmjF.08.0030   Qc-SNARE protein, putative
Leishmania mexicana LmxM.08.0030   Qc-SNARE protein, putative
Leishmania mexicana LmxM.21.1290   vesicule-associated membrane protein, putative
Loa Loa (eye worm) LOAG_10872   hypothetical protein
Mus musculus ENSMUSG00000026696   vesicle-associated membrane protein 4
Mus musculus ENSMUSG00000028955   vesicle-associated membrane protein 3
Mus musculus ENSMUSG00000050732   vesicle-associated membrane protein 8
Mus musculus ENSMUSG00000030337   vesicle-associated membrane protein 1
Mus musculus ENSMUSG00000020894   vesicle-associated membrane protein 2
Neospora caninum NCLIV_064090   synaptobrevin domain-containing protein, putative
Oryza sativa 4331733   Os03g0165800
Saccharomyces cerevisiae YOR327C   SNAP receptor SNC2
Saccharomyces cerevisiae YAL030W   SNAP receptor SNC1
Schistosoma japonicum Sjp_0213170   IPR001388,Synaptobrevin,domain-containing
Schistosoma japonicum Sjp_0023490   ko:K08510 vesicle-associated membrane protein 1/2/3 (synaptobrevin I/II,, putative
Schistosoma japonicum Sjp_0215640   Synaptobrevin-like protein, putative
Schistosoma mansoni Smp_055870   hypothetical protein
Schistosoma mansoni Smp_123870   vamp-2
Schistosoma mansoni Smp_102160.1   vamp-2
Schmidtea mediterranea mk4.007083.00  
Schmidtea mediterranea mk4.002446.02  
Schmidtea mediterranea mk4.016055.00  
Schmidtea mediterranea mk4.002579.03  
Schmidtea mediterranea mk4.001200.03   Synaptobrevin, putative
Schmidtea mediterranea mk4.019694.00  
Schmidtea mediterranea mk4.000000.58  
Schmidtea mediterranea mk4.007559.01  
Trypanosoma brucei gambiense Tbg972.10.820   vesicle-associated membrane protein, putative,synaptobrevin, putative
Trypanosoma brucei gambiense Tbg972.5.4970   vesicle-associated membrane protein, putative,synaptobrevin, putative
Trypanosoma brucei Tb927.5.3560   vesicle-associated membrane protein, putative
Trypanosoma brucei Tb927.10.790   vesicle-associated membrane protein, putative
Trypanosoma congolense TcIL3000_10_640   vesicle-associated membrane protein, putative
Trypanosoma cruzi TcCLB.511649.130   vesicle-associated membrane protein, putative
Trypanosoma cruzi TcCLB.507811.60   vesicle-associated membrane protein, putative
Trypanosoma cruzi TcCLB.508779.30   vesicle-associated membrane protein, putative
Trypanosoma cruzi TcCLB.506855.140   vesicle-associated membrane protein, putative
Toxoplasma gondii TGME49_248100   synaptobrevin protein

Essentiality

Bm1_53075 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.790 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.790 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.790 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.790 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.5.3560 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.3560 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.5.3560 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.5.3560 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F23H12.1 Caenorhabditis elegans embryonic lethal wormbase
TGME49_248100 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Bm1_53075 (Brugia malayi), Synaptobrevin
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